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Protein

5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase

Gene

purP

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.UniRule annotation

Catalytic activityi

ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase (purP)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei230ATPUniRule annotation1
Binding sitei258SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-311-MONOMER
UniPathwayi
UPA00074;UER00134

Names & Taxonomyi

Protein namesi
Recommended name:
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetaseUniRule annotation (EC:6.3.4.23UniRule annotation)
Alternative name(s):
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligaseUniRule annotation
Gene namesi
Name:purPUniRule annotation
Ordered Locus Names:Mefer_0308Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573064.Mefer_0308

Structurei

3D structure databases

ProteinModelPortaliC7P6G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 348ATP-graspInterPro annotationAdd BLAST233

Sequence similaritiesi

Belongs to the phosphohexose mutase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04346 Archaea
COG1759 LUCA
HOGENOMiHOG000228474
KOiK06863
OMAiKFPGARG
OrthoDBiPOG093Z04BP

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_01163 IMP_biosynth_PurP, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR023656 IMP_biosynth_PurP
IPR009720 IMP_biosynth_PurP_C
IPR010672 IMP_biosynth_PurP_N
IPR016185 PreATP-grasp_dom_sf
PANTHERiPTHR38147 PTHR38147, 1 hit
PfamiView protein in Pfam
PF06849 DUF1246, 1 hit
PF06973 DUF1297, 1 hit
PIRSFiPIRSF004602 ATPgrasp_PurP, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

C7P6G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKKEEILEI FDKYNKDEIT IATLGSHTSL HILKGAKLEG FSTVCITMKG
60 70 80 90 100
RDVPYKRFKV ADKFIYVDNF SDIKNEEIQE KLRELNAIVV PHGSFIAYCG
110 120 130 140 150
LDNVENNFLV PMFGNRAILR WESERSLEGK LLREAGVRVP KKYESPEDID
160 170 180 190 200
GTVIVKFPGA RGGRGYFIAS STEEFYKKAE ELKNRGILSD EDIANAHIEE
210 220 230 240 250
YVVGTNFCIH YFYSPLKDEV ELLGMDKRYE SNIDGLVRIP AKDQLEMDIN
260 270 280 290 300
PSYVITGNIP VVIRESLLPQ VFDIGDKLVA KAKELVPPGM IGPFCLQTLC
310 320 330 340 350
NENLELVVFE MSARVDGGTN SFMNGSPYSF LYNAEPLSMG QRIAREIKMA
360
LQLDMIDKVI S
Length:361
Mass (Da):40,790
Last modified:October 13, 2009 - v1
Checksum:iE3C12520B2C3DFBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24144.1
RefSeqiWP_015790884.1, NC_013156.1

Genome annotation databases

EnsemblBacteriaiACV24144; ACV24144; Mefer_0308
GeneIDi8364975
KEGGimfe:Mefer_0308

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24144.1
RefSeqiWP_015790884.1, NC_013156.1

3D structure databases

ProteinModelPortaliC7P6G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573064.Mefer_0308

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV24144; ACV24144; Mefer_0308
GeneIDi8364975
KEGGimfe:Mefer_0308

Phylogenomic databases

eggNOGiarCOG04346 Archaea
COG1759 LUCA
HOGENOMiHOG000228474
KOiK06863
OMAiKFPGARG
OrthoDBiPOG093Z04BP

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00134

BioCyciMFER573064:G1GFN-311-MONOMER

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_01163 IMP_biosynth_PurP, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR023656 IMP_biosynth_PurP
IPR009720 IMP_biosynth_PurP_C
IPR010672 IMP_biosynth_PurP_N
IPR016185 PreATP-grasp_dom_sf
PANTHERiPTHR38147 PTHR38147, 1 hit
PfamiView protein in Pfam
PF06849 DUF1246, 1 hit
PF06973 DUF1297, 1 hit
PIRSFiPIRSF004602 ATPgrasp_PurP, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC7P6G2_METFA
AccessioniPrimary (citable) accession number: C7P6G2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 10, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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