Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei905-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei915-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei945-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei120OrotateUniRule annotation1
Binding sitei148OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPyrimidine biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-310-MONOMER
UniPathwayiUPA00070; UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:Mefer_0307Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi573064.Mefer_0307

Structurei

3D structure databases

ProteinModelPortaliC7P6G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 156PribosyltranInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 1245-phosphoribose 1-diphosphate bindingUniRule annotation9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 159Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00029 Archaea
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OMAiMKAYQRQ
OrthoDBiPOG093Z0DC2

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit

Sequencei

Sequence statusi: Complete.

C7P6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKSKLIKL LRDIGCIKFG EFILASGKKS NYYIDIKKAT TNPEILKLVG
60 70 80 90 100
EMIAEQIRDE DVKVAGVELG SVPIATAVSI IAQKPLLIVR KKPKDYGTKN
110 120 130 140 150
KIEGELKEGD RVVIVEDVTT TGGSVLKAVN EIRENGGIVD KVFVVVDRLE
160 170
GAKENLEKEN VKLIPLVTVD ELRSA
Length:175
Mass (Da):19,215
Last modified:October 13, 2009 - v1
Checksum:iC62B44976DDD8CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24143.1
RefSeqiWP_015790883.1, NC_013156.1

Genome annotation databases

EnsemblBacteriaiACV24143; ACV24143; Mefer_0307
GeneIDi8364974
KEGGimfe:Mefer_0307

Similar proteinsi

Entry informationi

Entry nameiC7P6G1_METFA
AccessioniPrimary (citable) accession number: C7P6G1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health