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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186GTPUniRule annotation1
Binding sitei190GTPUniRule annotation1
Binding sitei233GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 71GTPUniRule annotation5
Nucleotide bindingi155 – 157GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Hmuk_2935Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHalomicrobium
Proteomesi
  • UP000001746 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi485914.Hmuk_2935

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 251TubulinInterPro annotationAdd BLAST193
Domaini253 – 370Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

C7P125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIIDDAID EAEEEREGGD PASEGPDQDQ SSTTPDATNT SGTMTDEELA
60 70 80 90 100
DVVKDLETKI TVVGCGGAGG NTVTRMMEEG IHGAKLVAAN TDAQHLADEV
110 120 130 140 150
KADTKILIGK KRTGGRGAGS VPKIGEEAAQ ENIEDIQQSI DGSDMVFVTA
160 170 180 190 200
GLGGGTGTGA APVVAQAAQE SDALTISIVT IPFTAEGERR RANADAGLER
210 220 230 240 250
LRAVSDTVIV VPNDRLLDYA PSMPLQDAFK ICDRVLMRSV KGMTELITKP
260 270 280 290 300
GLVNVDFADV RTIMENGGVA MIGLGESDSE NKAQDSIRSA LRSPLLDVEF
310 320 330 340 350
DGANSALVNV VGGPDMSIEE AEGVVEEIYD RIDPDARIIW GASVNQEFEG
360 370 380
KMETMIVVTG VESPQIYGQS EAEREKAAQQ LGEDIDYVE
Length:389
Mass (Da):41,061
Last modified:October 13, 2009 - v1
Checksum:i50C05E50D9343A83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA Translation: ACV49040.1
RefSeqiWP_015763882.1, NC_013202.1

Genome annotation databases

EnsemblBacteriaiACV49040; ACV49040; Hmuk_2935
GeneIDi8412488
KEGGihmu:Hmuk_2935

Similar proteinsi

Entry informationi

Entry nameiC7P125_HALMD
AccessioniPrimary (citable) accession number: C7P125
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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