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Protein

Lipoate--protein ligase

Gene

Lebu_0546

Organism
Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate.SAAS annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Lipoate--protein ligase (Lebu_0546)
This subpathway is part of the pathway protein lipoylation via exogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate, the pathway protein lipoylation via exogenous pathway and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported, TransferaseImported
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBUC523794:G1GFL-561-MONOMER
UniPathwayi
UPA00537;UER00595

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoate--protein ligaseSAAS annotation (EC:6.3.1.20SAAS annotation)
Gene namesi
Ordered Locus Names:Lebu_0546Imported
OrganismiLeptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)Imported
Taxonomic identifieri523794 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesLeptotrichiaceaeLeptotrichia
Proteomesi
  • UP000001910 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi523794.Lebu_0546

Structurei

3D structure databases

ProteinModelPortaliC7N8H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 214BPL/LPL catalyticInterPro annotationAdd BLAST189

Phylogenomic databases

eggNOGiENOG4105DF9 Bacteria
COG0095 LUCA
HOGENOMiHOG000260593
KOiK03800
OMAiEDWIHDH
OrthoDBiPOG091H03KP

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

C7N8H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYYVNKSND PAFNIALEEY CFKQLRDIDE IFLLWINEPT IVVGKYQNTI
60 70 80 90 100
EEINTEYTRE KGIHVVRRIS GGGAVYHDLN NLNYTIISNK QEDKEGFNFK
110 120 130 140 150
EFSKPIIETL AELGVKAEFT GRNDLEIDGQ KFCGNAQAYI KGRVMHHGCL
160 170 180 190 200
LFDVNFGELG NALKVSKDKI ESKGVKSVRS RVTNILPHLK QPITVNEFGE
210 220 230 240 250
KIMEYMKKHY PEMEEYKFTP EELKIIEENA EKKHRNWEWI YGTSPEFNIT
260 270 280 290 300
REKRFTNGKI QIFATVENSR IKNIKFYGDF FGKNEDLSEI ENLLKDTKYT
310 320 330
REAVKEKLET VDIEEYFSRF TVDEVVEVIV G
Length:331
Mass (Da):38,682
Last modified:October 13, 2009 - v1
Checksum:i27FF8D197E62EB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001685 Genomic DNA Translation: ACV38456.1
RefSeqiWP_012806638.1, NC_013192.1

Genome annotation databases

EnsemblBacteriaiACV38456; ACV38456; Lebu_0546
KEGGilba:Lebu_0546

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001685 Genomic DNA Translation: ACV38456.1
RefSeqiWP_012806638.1, NC_013192.1

3D structure databases

ProteinModelPortaliC7N8H5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523794.Lebu_0546

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV38456; ACV38456; Lebu_0546
KEGGilba:Lebu_0546

Phylogenomic databases

eggNOGiENOG4105DF9 Bacteria
COG0095 LUCA
HOGENOMiHOG000260593
KOiK03800
OMAiEDWIHDH
OrthoDBiPOG091H03KP

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

BioCyciLBUC523794:G1GFL-561-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC7N8H5_LEPBD
AccessioniPrimary (citable) accession number: C7N8H5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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