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Protein

NAD kinase

Gene

nadK

Organism
Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57Proton acceptorUniRule annotation1
Binding sitei62NADUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei218NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi57 – 58NADUniRule annotation2
Nucleotide bindingi153 – 154NADUniRule annotation2
Nucleotide bindingi194 – 199NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR469378:G1GFI-948-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Ccur_09610Imported
OrganismiCryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)Imported
Taxonomic identifieri469378 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteriiaEggerthellalesEggerthellaceaeCryptobacterium
Proteomesi
  • UP000000954 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi469378.Ccur_09610

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 2 hits
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

C7MP17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILIMRNAE SPAAIDASLM LGAYLSSQDI EFTLADAADP EGIIASSFDM
60 70 80 90 100
AVALGGDGTI LRTAKMIRYS RVPILGINYG HLGFLANGNQ GGVVAASAAA
110 120 130 140 150
LAGDTVAEER TNLRIFVQCE GDDDDQYESM CAGDADASID DDFAISRCLF
160 170 180 190 200
ALNEAALTRG ALGWMIDCEL SISGSLVGTV RGDGMVISTA TGSTAYALSA
210 220 230 240 250
GGPLVAPNFR GLVVVPVAPH SLIARAVVTD PHDIVELTLG DTRGDHEAQL
260 270 280 290 300
FVDGLAVEFP APIKRLRVQR GPEPTILLRY QGESFYTLLR TTFFEHTEPV

D
Length:301
Mass (Da):31,868
Last modified:October 13, 2009 - v1
Checksum:iA4A06358E8948815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA Translation: ACU94657.1
RefSeqiWP_012803343.1, NC_013170.1

Genome annotation databases

EnsemblBacteriaiACU94657; ACU94657; Ccur_09610
KEGGiccu:Ccur_09610

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA Translation: ACU94657.1
RefSeqiWP_012803343.1, NC_013170.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469378.Ccur_09610

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU94657; ACU94657; Ccur_09610
KEGGiccu:Ccur_09610

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Enzyme and pathway databases

BioCyciCCUR469378:G1GFI-948-MONOMER

Family and domain databases

Gene3Di2.60.200.30, 2 hits
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC7MP17_CRYCD
AccessioniPrimary (citable) accession number: C7MP17
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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