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Entry version 41 (08 May 2019)
Sequence version 1 (13 Oct 2009)
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Protein

DNA-directed RNA polymerase subunit

Gene

RPO31

Organism
Saccharomyces cerevisiae (strain JAY291) (Baker's yeast)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPO31Imported
ORF Names:C1Q_01530Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain JAY291) (Baker's yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri574961 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini254 – 565RPOLA_NInterPro annotationAdd BLAST312

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.UniRule annotation

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd02736 RNAP_III_Rpc1_C, 1 hit
    cd02583 RNAP_III_RPC1_N, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.132.30, 1 hit
    1.10.274.100, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000722 RNA_pol_asu
    IPR006592 RNA_pol_N
    IPR007080 RNA_pol_Rpb1_1
    IPR007066 RNA_pol_Rpb1_3
    IPR042102 RNA_pol_Rpb1_3_sf
    IPR007083 RNA_pol_Rpb1_4
    IPR007081 RNA_pol_Rpb1_5
    IPR035698 RNAP_III_Rpc1_C
    IPR035697 RNAP_III_RPC1_N
    IPR038120 Rpb1_funnel_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04997 RNA_pol_Rpb1_1, 1 hit
    PF00623 RNA_pol_Rpb1_2, 1 hit
    PF04983 RNA_pol_Rpb1_3, 1 hit
    PF05000 RNA_pol_Rpb1_4, 1 hit
    PF04998 RNA_pol_Rpb1_5, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00663 RPOLA_N, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    C7GMM0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKEVVVSETP KRIKGLEFSA LSAADIVAQS EVEVSTRDLF DLEKDRAPKA
    60 70 80 90 100
    NGALDPKMGV SSSSLECATC HGNLASCHGH FGHLKLALPV FHIGYFKATI
    110 120 130 140 150
    QILQGICKNC SAILLSETDK RQFLHELRRP GVDNLRRMGI LKKILDQCKK
    160 170 180 190 200
    QRRCLHCGAL NGVVKKAAAG AGSAALKIIH DTFRWVGKKS APEKDIWVGE
    210 220 230 240 250
    WKEVLAHNPE LERYVKRCMD DLNPLKTLNL FKQIKSADCE LLGIDATVPS
    260 270 280 290 300
    GRPETYIWRY LPAPPVCIRP SVMMQDSPAS NEDDLTVKLT EIVWTSSLIK
    310 320 330 340 350
    AGLDKGISIN NMMEHWDYLQ LTVAMYINSD SVNPAMLPGS SNGGGKVKPI
    360 370 380 390 400
    RGFCQRLKGK QGRFRGNLSG KRVDFSGRTV ISPDPNLSID EVAVPDRVAK
    410 420 430 440 450
    VLTYPEKVTR YNRHKLQELI VNGPNVHPGA NYLLKRNEDA RRNLRYGDRM
    460 470 480 490 500
    KLAKNLQIGD VVERHLEDGD VVLFNRQPSL HRLSILSHYA KIRPWRTFRL
    510 520 530 540 550
    NECVCTPYNA DFDGDEMNLH VPQTEEARAE AINLMGVKNN LLTPKSGEPI
    560 570 580 590 600
    IAATQDFITG SYLISHKDSF YDRATLTQLL SMMSDGIEHF DIPPPAIMKP
    610 620 630 640 650
    YYLWTGKQVF SLLIKPNHNS PVVINLDAKN KVFVPPKSKS LPNEMSQNDG
    660 670 680 690 700
    FVIIRGSQIL SGVMDKSVLG DGKKHSVFYT ILRDYGPQEA ANAMNRMAKL
    710 720 730 740 750
    CARFLGNRGF SIGINDVTPA DDLKQKKEEL VEIAYRKCDE LITLFNKGEL
    760 770 780 790 800
    ETQPGCNEEQ TLEAKIGGLL SKVREEVGDV CINELDNWNA PLIMATCGSK
    810 820 830 840 850
    GSTLNVSQMV AVVGQQIISG NRVPDGFQDR SLPHFPKNSK TPQSKGFVRN
    860 870 880 890 900
    SFFSGLSPPE FLFHAISGRE GLVDTAVKTA ETGYMSRRLM KSLEDLSCQY
    910 920 930 940 950
    DNTVRTSANG IVQFTYGGDG LDPLEMEGNA QPVNFNRSWD HAYNITFNNQ
    960 970 980 990 1000
    DKGLLPYAIM ETANEILGPL EERLVRYDNS GCLVKREDLN KAEYVDQYDA
    1010 1020 1030 1040 1050
    ERDFYHSLRE YINGKATALA NLRKSRGMLG LLEPPAKELQ GIDPDETVPD
    1060 1070 1080 1090 1100
    NVKTSVSQLY RISEKSVRKF LEIALFKYRK ARLEPGTAIG AIGAQSIGEP
    1110 1120 1130 1140 1150
    GTQMTLKTFH FAGVASMNVT LGVPRIKEII NASKVISTPI INAVLVNDND
    1160 1170 1180 1190 1200
    ERAARVVKGR VEKTLLSDVA FYVQDVYKDN LSFIQVRIDL GTIDKLQLEL
    1210 1220 1230 1240 1250
    TIEDIAVAIT RASKLKIQAS DVNIIGKDRI AINVFPEGYK AKSISTSAKE
    1260 1270 1280 1290 1300
    PSENDVFYRM QQLRRALPDV VVKGLPDISR AVINIRDDGK RELLVEGYGL
    1310 1320 1330 1340 1350
    RDVMCTDGVI GSRTTTNHVL EVFSVLGIEA ARYSIIREIN YTMSNHGMSV
    1360 1370 1380 1390 1400
    DPRHIQLLGD VMTYKGEVLG ITRFGLSKMR DSVLQLASFE KTTDHLFDAA
    1410 1420 1430 1440 1450
    FYMKKDAVEG VSECIILGQT MSIGTGSFKV VKGTNISEKD LVPKRCLFES
    1460
    LSNEAALKAN
    Length:1,460
    Mass (Da):162,320
    Last modified:October 13, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EAA762817DF06A8
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    ACFL01000063 Genomic DNA Translation: EEU07959.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    ACFL01000063 Genomic DNA Translation: EEU07959.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    CDDicd02736 RNAP_III_Rpc1_C, 1 hit
    cd02583 RNAP_III_RPC1_N, 1 hit
    Gene3Di1.10.132.30, 1 hit
    1.10.274.100, 1 hit
    InterProiView protein in InterPro
    IPR000722 RNA_pol_asu
    IPR006592 RNA_pol_N
    IPR007080 RNA_pol_Rpb1_1
    IPR007066 RNA_pol_Rpb1_3
    IPR042102 RNA_pol_Rpb1_3_sf
    IPR007083 RNA_pol_Rpb1_4
    IPR007081 RNA_pol_Rpb1_5
    IPR035698 RNAP_III_Rpc1_C
    IPR035697 RNAP_III_RPC1_N
    IPR038120 Rpb1_funnel_sf
    PfamiView protein in Pfam
    PF04997 RNA_pol_Rpb1_1, 1 hit
    PF00623 RNA_pol_Rpb1_2, 1 hit
    PF04983 RNA_pol_Rpb1_3, 1 hit
    PF05000 RNA_pol_Rpb1_4, 1 hit
    PF04998 RNA_pol_Rpb1_5, 1 hit
    SMARTiView protein in SMART
    SM00663 RPOLA_N, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC7GMM0_YEAS2
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C7GMM0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: May 8, 2019
    This is version 41 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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