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Protein

Kappa-conotoxin-like Im11.3

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like Im11.3
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStephanoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000039205527 – 70Kappa-conotoxin-like Im11.3Add BLAST44
PropeptideiPRO_000039205671 – 84By similarityAdd BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 43By similarity
Disulfide bondi36 ↔ 48By similarity
Disulfide bondi42 ↔ 51By similarity
Disulfide bondi47 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR020242 Conotoxin_I2-superfamily
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7DQY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCGT
60 70 80
CRNDNSSLTF LQFCLPFFFF LRPSHPLFLL LPAR
Length:84
Mass (Da):9,627
Last modified:October 13, 2009 - v2
Checksum:iB10DEBA8480ADB9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ184580 mRNA Translation: ACU30737.2

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ184580 mRNA Translation: ACU30737.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR020242 Conotoxin_I2-superfamily
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2B3_CONIM
AccessioniPrimary (citable) accession number: C7DQY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: October 13, 2009
Last modified: October 10, 2018
This is version 24 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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