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Protein

Conotoxin Em11.5

Gene
N/A
Organism
Conus emaciatus (False virgin cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Em11.5
OrganismiConus emaciatus (False virgin cone)
Taxonomic identifieri89442 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusVirgiconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000039204127 – 60Conotoxin Em11.5Add BLAST34
PropeptideiPRO_000039204264 – 68By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 43By similarity
Disulfide bondi36 ↔ 48By similarity
Disulfide bondi42 ↔ 52By similarity
Disulfide bondi47 ↔ 56By similarity
Modified residuei60Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiC7DQB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7DQB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRLTSVGC FLLVIACLNL FQVVLTRRCF PLGTFCSRYL PCCSGMCCSG
60
WCTRRCAPRF GKRATFQE
Length:68
Mass (Da):7,758
Last modified:September 22, 2009 - v1
Checksum:i78E21515C9CA94DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ180866 mRNA Translation: ACU30728.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ180866 mRNA Translation: ACU30728.1

3D structure databases

SMRiC7DQB8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2B5_CONEM
AccessioniPrimary (citable) accession number: C7DQB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: September 22, 2009
Last modified: October 10, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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