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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Methylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylorubrum extorquens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation
LigandNADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00098;UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotationImported
ORF Names:METD_I3636Imported
OrganismiMethylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylorubrum extorquens)Imported
Taxonomic identifieri661410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylorubrum
Proteomesi
  • UP000008070 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC7C9S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 296AldedhInterPro annotationAdd BLAST271

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000246356
KOiK00147
OMAiQYPAACN
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

C7C9S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVLNLKSDL ADADDLETLM AGIGRRARAA GRAMALAPAQ TKDLGLRAIA
60 70 80 90 100
EQIRASAPAI LRENARDVSA AQAAGLTNAI IDRLTLDEGR VAAIAEAVEK
110 120 130 140 150
VAGLADPVGR QLAAFERPNG LLIERISVPL GVVGVIFESR PNVTADAGAL
160 170 180 190 200
CLKAGNAAIL RAGSDSHRTA TAIAAAMSEG LARAGLPADA IQLVPTRDRA
210 220 230 240 250
AVGLMLTGLG GCVDVIVPRG GRSLVERVQA EAKVPVFAHL DGICHVYVAE
260 270 280 290 300
GADLGMARSL LLNSKMRRTG ICGAAETLLV DAAVAETHLK PLVEALLESG
310 320 330 340 350
CAVRGDAATQ AADPRVSAAT DADWRTEYLD AIISAKVVDG LDAAIAHIEA
360 370 380 390 400
NGSHHTDAII TDDTDAAARF LNEVDSAIVT HNASTQFADG GEFGFGAEIG
410 420 430
IATGRMHARG PVGVEQLTTF KYRVHGSGQT RPWTR
Length:435
Mass (Da):45,045
Last modified:September 22, 2009 - v1
Checksum:i48FE24A36FA4E6AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA Translation: CAX25276.1

Genome annotation databases

EnsemblBacteriaiCAX25276; CAX25276; METDI3636
KEGGimdi:METDI3636

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA Translation: CAX25276.1

3D structure databases

ProteinModelPortaliC7C9S4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAX25276; CAX25276; METDI3636
KEGGimdi:METDI3636

Phylogenomic databases

HOGENOMiHOG000246356
KOiK00147
OMAiQYPAACN
OrthoDBiPOG091H00OT

Enzyme and pathway databases

UniPathwayi
UPA00098;UER00360

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC7C9S4_METED
AccessioniPrimary (citable) accession number: C7C9S4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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