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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 35HelicalUniRule annotationAdd BLAST23
Transmembranei507 – 530HelicalUniRule annotationAdd BLAST24
Transmembranei673 – 700HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 144GP120InterPro annotationAdd BLAST112
Domaini143 – 506GP120InterPro annotationAdd BLAST364
Domaini525 – 715GP41InterPro annotationAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 359Sequence analysisAdd BLAST25

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909 HIV-1-like_HR1-HR2, 1 hit
Gene3Di2.170.40.20, 2 hits
HAMAPiMF_04083 HIV_ENV, 1 hit
InterProiView protein in InterPro
IPR036377 Gp120_core_sf
IPR037527 Gp160
IPR000328 GP41-like
IPR000777 HIV1_Gp120
PfamiView protein in Pfam
PF00516 GP120, 2 hits
PF00517 GP41, 1 hit
SUPFAMiSSF56502 SSF56502, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7BB88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVREIERNY QHLWRWITML LGMLMICSVT GQLWVTVYYG VPVWKEATTT
60 70 80 90 100
LFCASDAKAY KAEAHNIWAT HACVPTDPNP QEIQLENVTE NFNMWKNNMV
110 120 130 140 150
EQMHEDIISL WDQSLKPCVK LTPLCVTLNC TEWENTNRTN NNVTNEEIGM
160 170 180 190 200
KNCSFNTTTE VRDRKQQVHA LFYKLDVVPM NDNNSTDTNY TNYRLINCNT
210 220 230 240 250
SAITQACPKV TFEPIPIHYC APAGFAILKC NNKKFNGMGS CKNVSTVQCT
260 270 280 290 300
HGIKPVVSTQ MLLNGSLAEE EIIIRTENIS DNAKIIIVQL NESVTINCTR
310 320 330 340 350
PYNNTRKGTH IGPGRAWYTT GIVGDIRQAH CKVNKTEWNK TLERVAEKLR
360 370 380 390 400
DLINKTTIKF SPSSGGDLEI TTHSFNCGGE FFYCNTSRLF NSTWGDNNTS
410 420 430 440 450
SDTGESNITI PCRIKQIINM WQGVGKAMYA PPIEGLIRCS SNITGLLLTY
460 470 480 490 500
DGGARNNNQS ETFRPGGGDM RDNWRSELYK YKVVRLEPLG LAPTKAKRRV
510 520 530 540 550
VEREKRAIGL GAMFLGFLGA AGSTMGAASL TLTVQARQLL SGIVQQQNNL
560 570 580 590 600
LMAIEAQQHL LQLTVWGIKQ LQARVLAVER YLKDQQLLGI WGCSGRLICT
610 620 630 640 650
TNVPWNSSWS NKSIDEIWNN MTWMQWESEI DNYTGLIYKL IEESQIQQNK
660 670 680 690 700
NEKELLELDK WASLWTWFDV TNWLWYIKIF IMIVGGLIGL RIVFAVLSLV
710 720 730 740 750
NRVRQGYSPL SFQTLFPVPR GPDRPEEIEE GGGEQDRGRS VRLVNGFSAL
760 770 780 790 800
IWDDLRNLCL FSYHRLRDLI LIATRIVELL GRRGWETLKY LWNLLQYWIQ
810 820 830 840 850
ELKNSAISLF NTTAIVVAEG TDRFLEIIQR IGRAILNIPT RIRQGFERAL

L
Length:851
Mass (Da):97,051
Last modified:September 22, 2009 - v1
Checksum:i78869FEB0272D741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ866139 Genomic DNA Translation: ACO94115.1

Similar proteinsi

Entry informationi

Entry nameiC7BB88_9HIV1
AccessioniPrimary (citable) accession number: C7BB88
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 18, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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