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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Flavobacteriaceae bacterium (strain 3519-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFBAC531844:G1GFD-2468-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Ordered Locus Names:FIC_02495
OrganismiFlavobacteriaceae bacterium (strain 3519-10)
Taxonomic identifieri531844 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceae
Proteomesi
  • UP000001512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003897421 – 282Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST282

Proteomic databases

PRIDEiC6X3B5

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi531844.FIC_02495

Structurei

3D structure databases

SMRiC6X3B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 282CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IDZ Bacteria
COG0777 LUCA
HOGENOMiHOG000021671
KOiK01963
OMAiPEGLWIK
OrthoDBiPOG091H04JK

Family and domain databases

HAMAPiMF_01395 AcetylCoA_CT_beta, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00515 accD, 1 hit
PROSITEiView protein in PROSITE
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

C6X3B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFDWFKRKT KNITTSTEDK KDVPKGLWHQ TPTGKIIEHE ELKANNYVSP
60 70 80 90 100
EDGFHVRIGS REFFSILFDD NKFTELDANV ESVDMLGFKD TKAYVDRLKE
110 120 130 140 150
VKAKTKLTDS IRNAVGRVNG EQMVISCMDF AFIGGSLGSV MGEKIRRAVD
160 170 180 190 200
YCIANRLPYM IICQSGGARM QEATYSLMQL AKVQAKLAQL SEEGLLYIAY
210 220 230 240 250
LCDPTFGGIT ASFAMTADII MAEPGALIGF AGPRVIRETI GKDLPEGFQT
260 270 280
SEFLQEKGFV DFIVKRTEIK EKVSKTVKLL VH
Length:282
Mass (Da):31,563
Last modified:September 22, 2009 - v1
Checksum:iE905D94090E07CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001673 Genomic DNA Translation: ACU08928.1
RefSeqiWP_015807212.1, NC_013062.1

Genome annotation databases

EnsemblBacteriaiACU08928; ACU08928; FIC_02495
KEGGifba:FIC_02495

Entry informationi

Entry nameiACCD_FLAB3
AccessioniPrimary (citable) accession number: C6X3B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 22, 2009
Last modified: June 20, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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