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Entry version 68 (31 Jul 2019)
Sequence version 1 (01 Sep 2009)
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Protein
Submitted name:

Myosin E, putative

Gene

PF3D7_0613900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi185 – 192ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PFF0675C-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin E, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0613900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0613900

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C6KSY1

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
C6KSY1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C6KSY1, 17 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 900Myosin motorInterPro annotationAdd BLAST824

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1000 – 1019DisorderedSequence analysisAdd BLAST20
Regioni1055 – 1076DisorderedSequence analysisAdd BLAST22
Regioni1234 – 1428DisorderedSequence analysisAdd BLAST195
Regioni1555 – 1583DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1475 – 1502Sequence analysisAdd BLAST28
Coiled coili1651 – 1708Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1234 – 1272PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1282 – 1314PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1325 – 1392PolyampholyteSequence analysisAdd BLAST68
Compositional biasi1400 – 1428PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1565 – 1579BasicSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C6KSY1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAHNEAQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C6KSY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINPEEQQFK EGDLVWCNKI PSTCEEEDVL YILCRIIEKK SEDHIILTKY
60 70 80 90 100
DNETNGSTFV CESKHLYNAN NNNPFSLDED DMIKLKHFNE PTVLYHLHGR
110 120 130 140 150
YEKNIFFTKM GPLLIYVNPM EKEKNYENNT LNKINNINDI CNDVIEKYKY
160 170 180 190 200
SHSSDDIKLN EYHVGMSALK YMNVLKKNQS IIITGESGSG KSKIFNSLLN
210 220 230 240 250
FFSNERIFPL KKKFEIRNDD NINISEILKH GNIIMEALGN AKTSKNNNCN
260 270 280 290 300
RYAKYCILQM DKDKIKHIYM KKFLFDKERL INRRSDENNF HIFYYILNGS
310 320 330 340 350
SENFKKKYFL KNLEDYNIFK NDSIRDNSND EQNFIQLLTS LNILFDDDKK
360 370 380 390 400
QIDFFFSILS AILLLGNIQM IKSPKKSLFR QNFICEFPSN YKQLQEQLEF
410 420 430 440 450
LDESHIWDMS KKSSSSSSYD EGSSNLSNMD SSEYLDKNTY IFLVASKLLG
460 470 480 490 500
IDAETFLKYF TSGYLLNEII LMKGQNEMKV QKKIERFMKT CYEELLNWVI
510 520 530 540 550
CKITTKYNDN LINNKEKEII QNNEIFENEK SEKNDNYINV LDIIYFENLK
560 570 580 590 600
ENSLEQFLIN TTNEFILKVY TDFYYKKREN IYKQEGLELS CDSIYIDNEQ
610 620 630 640 650
LYKILISKEG SLFSLLENIC TKKSFDKSNL CSTIVNRFIK NPYIKANSLE
660 670 680 690 700
VNKAFIIIHS YSQISYKTEH FIEKNVDILT RGFIEMIKKS DNKYMQQFCS
710 720 730 740 750
SYDYDTNGKI MEENKRFSVH TNFKLFKKEY DPNNQMAVTL LRNNLLELTN
760 770 780 790 800
SIEKSFCHFI MCINTCRKKI NTEMVPHFDK KLVLSQVTNF HMMIEADQFK
810 820 830 840 850
DEYFPHMFSF FEFVQIFKCL KNYKKINHEG DDIHVHENVN NMENMYHTNN
860 870 880 890 900
PFDNVESNDN KTVCEQILGY MKIGEKNWTI GKNMIFLNEK SMNILVDSVY
910 920 930 940 950
YMWLNSLENE SGKEELCDLK EMMKENDKGE KYEKRELEYI NLDYENVEIQ
960 970 980 990 1000
MENDQSYLNC DNKNVDTIKE MEVEIKIGSY NTELNNKMVD HDIVDNKYDR
1010 1020 1030 1040 1050
DDNVHRKSST NMSYDDNQNM EGGLLKVNLK KGDNTSLSDM EEEYVNVNVN
1060 1070 1080 1090 1100
VNDEEEKMRR MSKEKDRKGS KVKRKSSLLR LSTSLRNSFQ KMKKSKLNEK
1110 1120 1130 1140 1150
EEKVGEKVEE KVGVKVEENV GVKVDEKIGV KVEEKVGVKV EENVGENVSE
1160 1170 1180 1190 1200
NVGENVSENV GENVDEKVCE EKDDGYGVMN FFNNINFYKK GLKELNNAIK
1210 1220 1230 1240 1250
NFNPINGKLK KDKFFNMGIQ NFYNKKKNFF LDSKRGSDAS KKGEENKDEQ
1260 1270 1280 1290 1300
ENKNEEDNID VKDNKGEEDN IDVEDNKGEE DNIDVEENKN VEDNKDEEVN
1310 1320 1330 1340 1350
IDVEENKNVE DNKDVEDNID EEVNIDVEEN KNVEDNKDEE VNIDVEENKN
1360 1370 1380 1390 1400
VEDNKDEEVN IDVEENKNVE DNKDEEVNID VEENKNVEDN LDVEDNLDVE
1410 1420 1430 1440 1450
DNLINVKESK DTEVQNDEQK IDKNNEEDIK DNVIEDMNKE QNNYNKMFKV
1460 1470 1480 1490 1500
EDNIIDLDYV DLSNLEKCMN EEDTNNMDED EKNNMKDDIN EEQNNIDEIY
1510 1520 1530 1540 1550
KSDDHVVNLD NTKKDVNNND KSNVTEELEN MNYMKTKTED DKREDMEICE
1560 1570 1580 1590 1600
VKENKPDDNQ INNVQKKKKK KKRRKKKKKS VLNNVEDKNM FDNDVSVEKD
1610 1620 1630 1640 1650
MMEKDISDEK YMMDDDNNMM NPDNVTNVNK DILNIEKVMI YDYHNVPDDD
1660 1670 1680 1690 1700
NMMSEKKMDN MENEYEKIKE EKIDEIEIEY DKIKEENIDE IESEYDNIKE
1710 1720 1730 1740 1750
EYIDEIELDN KENVEDEKEE ECVEETKIRD DEIYYDKMGD MEKNKSTSNI
1760 1770 1780 1790 1800
GIELYDNEKN SDDSCVHNED SNNLTKCDEE DCLDENTKDC YDDYMDENYI
1810 1820 1830 1840 1850
DFDFSCVKAI TLNKLGNMNE LSCYKNDEND IIQTLFDYYD CSYDKAYENC
1860 1870 1880 1890 1900
FFENRWDDIV EEDDSFIFLN VYNNKEMSNL RNSENKDMLL NHLNDIYICK
1910 1920 1930 1940 1950
NNEKQHVMKI IKRMKNAMEK VHGNNKWNIL FSFSDCCIRS FIHDKDNVHI
1960 1970 1980 1990 2000
EKNVDLLKEK ILFYNEEYCI YNNKENELNE YTYNPIVEYV ALPRNKEVHE
2010 2020 2030 2040 2050
ICISNNIHKN FIKNNYKIMC FQPTKISYKD FLKSKLFYKS INYTNFQTRN
2060 2070 2080 2090 2100
ITQVTIDFSY MDDKMKNNFK QHVINEFVNN PNITKEDLSN SLFHLATYFY
2110 2120 2130 2140 2150
HEKNKEPGTW CVFISEEKGF AGAVNIVKNK YLRMTAQNKN KKYNILVFKT

PAL
Length:2,153
Mass (Da):255,084
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F24F3C12C43D5AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25378.1

NCBI Reference Sequences

More...
RefSeqi
XP_966126.1, XM_961033.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAG25378; CAG25378; PF3D7_0613900

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0613900.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3885717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0613900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25378.1
RefSeqiXP_966126.1, XM_961033.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiC6KSY1, 17 interactors

PTM databases

SwissPalmiC6KSY1

Proteomic databases

PRIDEiC6KSY1

Genome annotation databases

EnsemblProtistsiCAG25378; CAG25378; PF3D7_0613900
GeneDBiPF3D7_0613900.1:pep
GeneIDi3885717
KEGGipfa:PF3D7_0613900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0613900

Phylogenomic databases

InParanoidiC6KSY1
OMAiNAHNEAQ

Enzyme and pathway databases

BioCyciPLASMO:PFF0675C-MONOMER

Family and domain databases

Gene3Di3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
PfamiView protein in Pfam
PF00063 Myosin_head, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC6KSY1_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6KSY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 31, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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