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Entry version 76 (29 Sep 2021)
Sequence version 1 (01 Sep 2009)
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Protein
Submitted name:

Rhoptry protein ROP14

Gene

PF3D7_0613300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • protein maturation Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rhoptry protein ROP14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0613300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0613300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
C6KSX6

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
C6KSX6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
C6KSX6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili947 – 1024Sequence analysisAdd BLAST78
Coiled coili1066 – 1086Sequence analysisAdd BLAST21
Coiled coili1110 – 1144Sequence analysisAdd BLAST35
Coiled coili1152 – 1195Sequence analysisAdd BLAST44
Coiled coili1321 – 1341Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipase maturation factor family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_253021_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C6KSX6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCILTEC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C6KSX6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009613, LMF

The PANTHER Classification System

More...
PANTHERi
PTHR14463, PTHR14463, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06762, LMF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C6KSX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKNDVKEET KILLNDKDID KNKKVGKIRY CINNFFKTLF QKNVQYDTFF
60 70 80 90 100
YKNKSLENTF WSSQIIYTRI LLISCLFSFI VSWNQNVALI GENGLTPAKN
110 120 130 140 150
YVDKMFDELQ NESIWVKFQN FHSLFWFIPA SDFNINLLAI IGIVLSCFSL
160 170 180 190 200
LFNYTNLVTL VPIYIILQSI YSIGNIWFNY VYEIEILELL FLCFFLVPFC
210 220 230 240 250
GNHLKKRFSP TCLIKYICRC FVFKVLIGTS LIRFKNSDLW GKLLGKYYLY
260 270 280 290 300
ETQPLPTSIS YLFHSCITLS KLDNIFCILT ECVFSFLILF PIRSFRLVGG
310 320 330 340 350
SLIFIYCILN FITGNSYLFY FLLIAPLMFC FDDKILLRLF FFKWKRYEII
360 370 380 390 400
NIVKEKLANK NKSKRYFKSF DIFYFTGFNS DDLIKIYDNY FNIKYQKAYL
410 420 430 440 450
GKSPKKNNTL NKYNEQSSYD DNYEQEDEEH YYYDDEEDNE YDEDNYDISY
460 470 480 490 500
NNSLNYQITK EQIHNNQSPQ KQKEQQQQYR ALIPKSSSKE INLFYKKQNI
510 520 530 540 550
LKSIKNDLYN TFYWLFSQKG LQYIIKNYNV SVEIFIHIIC SLLIIIFNSI
560 570 580 590 600
VTISIYPITS ILFYIYIVLF LSYVIFLFGY TKNIFSRIIS QLSLLLVILL
610 620 630 640 650
IYSNQIFLHG FVNIYYNSLF FIHLLTLCIL SMFYLNNKRF IFKFTTQYFY
660 670 680 690 700
FILFIYFAYF FLQNILSPNQ IMNAQYGSFE IMNIYGSFGK IKKNRKEILI
710 720 730 740 750
EGTQSEKIDD NTTWHTYEFY CKPDNIYKNM CTQFRLLYNF IPVLYIDRLD
760 770 780 790 800
WQFNTLSDKE DETILQNEWF KNFLIKLSNN DKNILSLLYK NPFQNIKNIN
810 820 830 840 850
NKNTIFLRIS NATYKFAKNG QKNWWDVVSS KVIVNPHQVS KLPEQVRLNL
860 870 880 890 900
YNMHEQIEQA KRIKLNNIGN KDLYDENMLN YKKKYNMRKY KIMDTNMDDI
910 920 930 940 950
ERTKETKNDI IINDKIIGID FKYDNVDNDF ESTYKEESYP NLRKIKKEKH
960 970 980 990 1000
NEAKERHEQN FNKQYERVKK ILEDHKKILE DENEIINKEK KKLQNQKDLL
1010 1020 1030 1040 1050
NKEKQKLQEE KKKLVYQKKM QEHNMLEQDQ KIQEEKKKLL YQKKMQEHNM
1060 1070 1080 1090 1100
LEQDQKIQEE KKKLLYQKKM QEHNMLEQDK KIQEEKFMEK KQKLTEQFLE
1110 1120 1130 1140 1150
QKQKEDEQIL ERNKIEKQNI MNKLKKLEEE KNQFEKKKLF LEQKKIQEQK
1160 1170 1180 1190 1200
AIDHEKKYLQ QQQNKLLQIK KEIQHQKEEQ QHKVDEQLNQ KLKNEFMLQN
1210 1220 1230 1240 1250
EDTINKKKIY YPIHNNNTNV NNNSDMYDMN KYNTKELNEK INNEIESELE
1260 1270 1280 1290 1300
NNVEPFPHQI IYNNGKHEQV KYENKYLKDH LNDHLNKHFK NNNHNKLKGS
1310 1320 1330 1340 1350
YNKTTQQNYS NDDDISYLGQ KHQINNKFEK IENKINNEQS NNKLQKFTVD
1360 1370 1380 1390 1400
EKIKNELDNA IKNSYSKYNL LNNYTNKINK LGLLNVYNNP NNVSNINTLK
1410 1420
YKPYDKYHNE SYITDTVNEN IE
Length:1,422
Mass (Da):172,015
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i758C93FCDDC8AA0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25372.2

NCBI Reference Sequences

More...
RefSeqi
XP_966120.2, XM_961027.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAG25372; CAG25372; PF3D7_0613300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0613300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3885755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0613300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25372.2
RefSeqiXP_966120.2, XM_961027.2

3D structure databases

SMRiC6KSX6
ModBaseiSearch...

PTM databases

SwissPalmiC6KSX6

Proteomic databases

PRIDEiC6KSX6

Genome annotation databases

EnsemblProtistsiCAG25372; CAG25372; PF3D7_0613300
GeneDBiPF3D7_0613300.1:pep
GeneIDi3885755
KEGGipfa:PF3D7_0613300

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0613300

Phylogenomic databases

HOGENOMiCLU_253021_0_0_1
InParanoidiC6KSX6
OMAiFCILTEC
PhylomeDBiC6KSX6

Family and domain databases

InterProiView protein in InterPro
IPR009613, LMF
PANTHERiPTHR14463, PTHR14463, 1 hit
PfamiView protein in Pfam
PF06762, LMF1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC6KSX6_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6KSX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: September 29, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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