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Entry version 50 (02 Jun 2021)
Sequence version 1 (01 Sep 2009)
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Protein

Protein PFF0380w

Gene

PFF0380w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PFF0380w
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFF0380w
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0607700

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003707361 – 2752Protein PFF0380wAdd BLAST2752

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C6KSS5

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
C6KSS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Developmental stagei

Merozoite

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C6KSS5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1277 – 1354HTH OST-typePROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 44DisorderedSequence analysisAdd BLAST25
Regioni139 – 160DisorderedSequence analysisAdd BLAST22
Regioni634 – 678DisorderedSequence analysisAdd BLAST45
Regioni1048 – 1130DisorderedSequence analysisAdd BLAST83
Regioni1153 – 1172DisorderedSequence analysisAdd BLAST20
Regioni1457 – 1499DisorderedSequence analysisAdd BLAST43
Regioni1958 – 1999DisorderedSequence analysisAdd BLAST42
Regioni2063 – 2099DisorderedSequence analysisAdd BLAST37
Regioni2501 – 2537DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 158Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1048 – 1062Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1063 – 1130Polar residuesSequence analysisAdd BLAST68
Compositional biasi1465 – 1499Polar residuesSequence analysisAdd BLAST35
Compositional biasi1959 – 1973Polar residuesSequence analysisAdd BLAST15
Compositional biasi1974 – 1995Acidic residuesSequence analysisAdd BLAST22
Compositional biasi2068 – 2098Polar residuesSequence analysisAdd BLAST31

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_227057_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C6KSS5

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMKEDTP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025677, OST-HTH-assoc_dom
IPR025605, OST-HTH/LOTUS_dom
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14418, OHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644, HTH_OST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C6KSS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFEKENKTC MKDVRYDLQE REKEEEEKKR NYNISNNNNN NNYNKYDKNY
60 70 80 90 100
ISHVADYINR KQINNMNDNN MNKSCIMKRF NKKDVKYNDM LLKADETYIN
110 120 130 140 150
DGQIKKKYNN NNNNNNNNTK SIYLTNTYNK SSSIHNKPHI HKNNDINNIH
160 170 180 190 200
EKNDKSNNDY NYSHNNISFD YNVEPVYNYI NEGHNPDISL NKMEIQKGTY
210 220 230 240 250
NNYCYENFIV NDDVDSYRDT HENNIMLLDD ENNNSIFIKK NKSSFYHTSQ
260 270 280 290 300
HNNQGFINTN DTIKRNKNFV LQKNDINLTN DKINSSFNKK KNKLTSIYVE
310 320 330 340 350
REDQKVGPLN VNNDMSILNK KKESKHNFYK SMNEHDVIAE KKKNTILKNK
360 370 380 390 400
CVEDDNIRTI ENVHNDSLKN EHMNDIYMKD NNNNINTYKI VHDKPLSAVE
410 420 430 440 450
NLQEVNKKKN YKNVIFKHLF NNDKDDNVYN LKKNKNNDVV EFNMNKKMTL
460 470 480 490 500
ISGNKMYKNE TAKMYNSNQE IYISNNNNDN NNDNNNDNNI NNYHHGYKKY
510 520 530 540 550
NTTNQYNNNN NNNNNSNIYP FYKNTSINNC NNKKINEYDN NLFNNKKDIL
560 570 580 590 600
NNTNFVKSQD YHDNKNIQYN INSNDNYYHS FGDIKNEGNM NTMFNVKKKY
610 620 630 640 650
KKVRINSHIS SKLNDKSIIN YRNGVINNQF NHMNDIVSSN NNNNNNNNNN
660 670 680 690 700
NNNNNNNNNN NNNNNNNNNN NNNNINMKTS ICNNKKRKNT KNFSLNLCSA
710 720 730 740 750
CLNIDDKIYI KQIKEILDRD INLLNEDPRI INALKKSHIS TSYLFNNLKS
760 770 780 790 800
LGTFRKGGLT WAIYYNNNNK GVNNMIKIKN EANNRIVKDK LLNNMNCTNI
810 820 830 840 850
MNDIKNINTL ATNNGGGYNL NNVNNMSNIY NVVDAKNGNH MNNRKDMSIN
860 870 880 890 900
TDCFNYTNSI DEMDDINENN KKKDNFPFLN NSNIDSDNNY IELIKNNSFC
910 920 930 940 950
NDKYIIEPII ENTWLKKVLL IIKKESLDIE CFLFKIKYYF YKSVLFLYQE
960 970 980 990 1000
GIKSYLGDVA NQMKIYINYN FWSAAEIAFI LRQITSLCNI QIEVRVKGEI
1010 1020 1030 1040 1050
GCVIYLNEEP EWFQGFVDSH NLNDTFSKKD WYLLNNFAIK MMQYRKGDKK
1060 1070 1080 1090 1100
SEDMKEDTPT RGENLQRGQN LQRGDNLQRG DNLQRGDNLQ RGDNLQNGDN
1110 1120 1130 1140 1150
LQNGDNLQRG DNLQNGENLQ SGENLQSGEN LQSGENLQTR ENLQSGENLQ
1160 1170 1180 1190 1200
TRENLQSDEN HNNILYPYNN NGQYEDNYNN SYNNNNNECI FCSSSNKKLK
1210 1220 1230 1240 1250
SYMFNGGRYA FAAKLKEEIK HFHSKRLGDI IHLVQLAIHK GIFVYSQRIL
1260 1270 1280 1290 1300
LPVSACEKSA DDLYPKIRNL NYDICETLEE VLEIISLLVD HKTNGLVLAQ
1310 1320 1330 1340 1350
LKQQFILQFK KELNSLHFGY KKLQNLLMAE PFNKYYKLYI PNNNLHRTHI
1360 1370 1380 1390 1400
QHKKYKTPDN CRIFQKENIH LKNHLDFIYN TEFFTELYVE DEYYDNEDTK
1410 1420 1430 1440 1450
QSIQPIYDNI ISTSCNNHIQ QQNGSLYMSN TTFRNDKEEI KKDIYLLNIR
1460 1470 1480 1490 1500
DSQNKRDIKQ DNISKKKINN INSNNSNNSN SNSNSNNNNN NNYNSNNISD
1510 1520 1530 1540 1550
NKLELTYQNI HNLPSYIQKS IETIFEKNNK ENDKSKWIEE EEEEKEECPL
1560 1570 1580 1590 1600
KEINKNIQHN KNYDYIINNN IFQNRGSNNI QSYDDRNQNK QIQFLNTLYH
1610 1620 1630 1640 1650
IDVELSPVNT KRYNKIKDIF TNMIKINKKC NDNIINNDDI IKNDHDEFIN
1660 1670 1680 1690 1700
DDQHYNIWNV HFEKRTLLNR YKQDNTTGAT NVVSPILNIY TLIKKYKIKK
1710 1720 1730 1740 1750
KKYESFFDDI NNDVDIHVNN KTEQNKDNGH IENNNINNIN NNINNINNNI
1760 1770 1780 1790 1800
NNINNNINNI NNNVNNYYYI DNGDGNNIHK GYINNYIIPE DNPIHNNFTY
1810 1820 1830 1840 1850
DNNKKNTTKQ TLQLLHNTEI NFIPDIDPID VTNVNINRKN KMNKIYKTKN
1860 1870 1880 1890 1900
VINRHHTNKS METFEPNNKL DSYEDRNIQF YNENCNRYMN ADYKTGQSTL
1910 1920 1930 1940 1950
PILSGTTNNI RYKTGESTLP ILSGTTNNTR YKTGESTLPI LSGTTNNTRY
1960 1970 1980 1990 2000
KTERFFKAKN SNQENINQNE INYNNNDDDD DNNNNNNDDD DDDNNYYMLN
2010 2020 2030 2040 2050
NQYGDNIMTE SNYISSHNNL PQEDIFNDEK KIIEMIEKTI DQDYINIEDK
2060 2070 2080 2090 2100
NDVKHDMIKK INKRKNNNIH NYNDNNNDNN NDNNNDNNND NNNDNNNDKY
2110 2120 2130 2140 2150
FIFDKDINNN VDENNINNIH LKDNIKKKKE KNEYNNYKIS SYNNNDGDNY
2160 2170 2180 2190 2200
GDNNNNLINN SIYYYDSSKN RSIKYGDEYE EEIYNTKNVI NQKNYGNINN
2210 2220 2230 2240 2250
YDYNVIFTNI AQVNDENLYI PNSRSINIDI NDTDNNNCVK NITYINNNSN
2260 2270 2280 2290 2300
PLESNNNGST TTTTTTTSIK NNMKHYNVDI NNLDDIKDIY MYNSNNNDST
2310 2320 2330 2340 2350
NVERDNNNIN IEHVGEKPFC YYTHNYNNNV SNINFNTFNP SLNLIMNNPK
2360 2370 2380 2390 2400
KNNDQNSIFK KEQYSSYEPV KNNDINIFYS NKYDNNSNYI YEQKIKKNEN
2410 2420 2430 2440 2450
DVIYKNDDKI FSNLNKSEEC VHSSNSFVNN LYIPYNNMKD KDNIMSPQNN
2460 2470 2480 2490 2500
IIYDEQINNI NNFTLNNHNM NNGHNIGDEY SDESYEIRHI NNINKKDNLM
2510 2520 2530 2540 2550
DENNILNNNN DNNNNNNDKS NLVLHNNNDK SNHFLHNNNN DSYNYDIYNH
2560 2570 2580 2590 2600
FHTYNNCNLY NDDKNELSKK GAVLNRYNEQ EQNIPIEHEY NNISYPSLIK
2610 2620 2630 2640 2650
NNKNNSEKKY LDNLSINLKD EKNYHPEKKN FNNNLEKNNK IFTNDIEHIS
2660 2670 2680 2690 2700
FNKKICKIKN IYSENKNNQF FKNNTNHLFN TNINLYEKKN YVDDEFSHHK
2710 2720 2730 2740 2750
DPIKFSSLIK NKQNNNNSFM NLLNDNQYVK INNQNTFNNP NKYHHMKNKI

NK
Length:2,752
Mass (Da):325,017
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44539CDE80FF6F4F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25247.1

NCBI Reference Sequences

More...
RefSeqi
XP_966067.1, XM_960974.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAG25247; CAG25247; PF3D7_0607700

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0607700.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3885834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0607700

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25247.1
RefSeqiXP_966067.1, XM_960974.1

3D structure databases

SMRiC6KSS5
ModBaseiSearch...

PTM databases

SwissPalmiC6KSS5

Proteomic databases

PRIDEiC6KSS5

Genome annotation databases

EnsemblProtistsiCAG25247; CAG25247; PF3D7_0607700
GeneDBiPF3D7_0607700.1:pep
GeneIDi3885834
KEGGipfa:PF3D7_0607700

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0607700

Phylogenomic databases

HOGENOMiCLU_227057_0_0_1
InParanoidiC6KSS5
OMAiDMKEDTP

Family and domain databases

InterProiView protein in InterPro
IPR025677, OST-HTH-assoc_dom
IPR025605, OST-HTH/LOTUS_dom
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF14418, OHA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51644, HTH_OST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRR2_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6KSS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: June 2, 2021
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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