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Entry version 60 (22 Apr 2020)
Sequence version 1 (01 Sep 2009)
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Protein
Submitted name:

AP2 domain transcription factor

Gene

PF3D7_0604100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PFF0200C-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AP2 domain transcription factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0604100Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0604100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
C6KSN9

PTM databases

SwissPalm database of S-palmitoylation events

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SwissPalmi
C6KSN9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C6KSN9, 11 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni81 – 128DisorderedSequence analysisAdd BLAST48
Regioni774 – 800DisorderedSequence analysisAdd BLAST27
Regioni857 – 891DisorderedSequence analysisAdd BLAST35
Regioni953 – 984DisorderedSequence analysisAdd BLAST32
Regioni1499 – 1526DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi97 – 128PolarSequence analysisAdd BLAST32
Compositional biasi865 – 891PolyampholyteSequence analysisAdd BLAST27

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_236436_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NINSEEC

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C6KSN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDNLVKESN EIIGSCTVDG VHSSIMQKNM CSSDIILDDT NSKSLCDSNK
60 70 80 90 100
LKKDNEKGID ENIKETSTCT YTVDENVMKS NEEKNDEDDD GSNNVDVVGD
110 120 130 140 150
NIGNLPNENM DNRNNNDNNN INNNIQYDNV NNNNNINNND SGGYSHSNDI
160 170 180 190 200
LNSNINQIVP FVNNANNEEQ NKMREHIGSQ EPVILIDKIE RCLVVEWYEN
210 220 230 240 250
NIRREQRISY KKYGNDKAKL RAKELIEKLK SGITFEQLYP DKGPPIVRVF
260 270 280 290 300
ENVGVYNVSL IRDRIEREWR VEWLENGVPM KARWSCKKVG NDEAQKRADT
310 320 330 340 350
FAQSMIKGIF NPILLHKATG TRFSRSDKSV VKINVYMNKN IKCLTNGIED
360 370 380 390 400
DLNTDHHHHH HNNNNNNCVK TFSIKGEVPS STLNHKVTRS YRRRKKKNDI
410 420 430 440 450
NNTMEIQDGN VRSMTYLVNN NSSYLNHSNN MNPNLCNMNL MDYQMNEMYQ
460 470 480 490 500
GNNMSNMMLL DNNMKNMIHH NNVNNDLLLN SDLYNDKKRT RSSRTTRKRN
510 520 530 540 550
ICKTEKSMIT KNGNKYMINN DKNIQMNKND ILVNTYLVKN ELCNNYQNEP
560 570 580 590 600
NNNNNNNNNN IMMMMNNNKK KVKTQLNNNI KNSYYIPSEQ YEMFCSANNI
610 620 630 640 650
VSGNRNKRAN KSAYKITKNN KNNDFVNYNN ISNTIPDNVT DEVQNYQYML
660 670 680 690 700
NDNMNGEYLN LNEYPMRNTE DGVDNYYQNK NYYYLYNNNN GMLVKTYVVD
710 720 730 740 750
QEGNHNLVKN NNFVKIENTD YLYGGTSTNK CQPIADKRIN NNYDSSSNKY
760 770 780 790 800
KQNMLEYNNN YNLNVDKKGM NFTGSVSSLD AKKKKRKNSR SSKNRNTLET
810 820 830 840 850
PYDNYTINYN VTCTKDKRGK NKKDTCENIN DNIYENRNND ENLVGAKRRT
860 870 880 890 900
KRVIATRKKK NARGKYKNND NEDNNDIDGN EKNIGNEKDK ENYEEKIEQG
910 920 930 940 950
YIKEEYIVHG CEEEVKGLEE NKGRKRRRIK SSKFYDNDEY IYSLDKTYNK
960 970 980 990 1000
KKASQYNNNN NDNNNDNNDN NNNNNNDNNN YGNTMVQNEF NRYFMNNNNY
1010 1020 1030 1040 1050
MVMNNMHTNN MLNNEGHYLN NNIYCKNEMQ NVSFNNISRE NMNMMNIPNM
1060 1070 1080 1090 1100
VNMNNLTNIN SAYNVKTIEN YNNGDKMNNP SFVNNCIEFV ENPRGYRVPY
1110 1120 1130 1140 1150
EYQSQRFYEY FEVPLNSRKE FEMQQKYFAN LFSLHILAVG WNVNKGDGME
1160 1170 1180 1190 1200
NNNIPQLTDQ NMIPNGNNNN NNNTYELVPY NEKENIMNNK ELLSSKEQIN
1210 1220 1230 1240 1250
GPYIPYNYKP IYHVEPFSSD VNNNMNSNCN YYIDLENMNS TKIDGKEYTY
1260 1270 1280 1290 1300
NEVQTMNNYR AINKKESLEN VANYENMMNY DNISNYNNPD DVINQRSNVA
1310 1320 1330 1340 1350
NISDHNNNLN NISAVNDVHN IIDKNNMNHI PYYNDMNNNI TNYANMTGIQ
1360 1370 1380 1390 1400
NLNNMNPIMI DPNNNADSVE EFYDAIDGCN VVDTNYMVGT NNMIDQIHFN
1410 1420 1430 1440 1450
DVTSNVGNMN NNLTNFSNPY NSVKVINDLN NTGEMNNNMI HLNNKNEMTG
1460 1470 1480 1490 1500
LGNMNDNVHI NNASVIKENG NSNSSKEMNH MNMEKLYVSQ MNYSTNDLIH
1510 1520 1530 1540 1550
MNNNNNKNNN NNKNNNNNNN NNNNSNVNVV GIENSVNSTV YDNMNNYIPM
1560 1570 1580 1590 1600
NTINVNYMND SRSDLMNGKN NINVEYKNVR GYDETLSNRS DMISYNMSGL
1610 1620 1630 1640 1650
DHFNDNRYRN DMDPLGKTNI LNNHNNIGSV NIYNNQTDLI NNYFNNNNNN
1660 1670 1680 1690 1700
NNNKYANINS SDMYKEQYYN THMNHLINDN KEISNNFDDS KKNVKGITNG
1710 1720 1730 1740 1750
DNKDLLNVHN NANIKINNTC NINDTSNMLQ ENNIATNKKD LQVINKNMVL
1760 1770 1780 1790 1800
TYTCNNDDMI NSLNGVNDLS NDPNDGSLKE NRKNEPSFIN TNVNVNVNNT
1810 1820 1830 1840 1850
NKNKVNGDND IESNTLLGED NNKINEKTIH SNSIYKNCNG SSDDANVPYE
1860 1870 1880 1890 1900
NSDHLYFMEK EKYASDNVVN RNAHNQFKDS YYNLLSNEDV NNNITNENNN
1910 1920 1930 1940 1950
NSDDMSCNQY MKKNNNTSNK IIKEMNNYDF YSNKKMIDKL RSTSNSSTIN
1960 1970
TEYLPSNLLN SISINNVSQS NQINEHVDK
Length:1,979
Mass (Da):229,626
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87D5964845A60EAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25211.1

NCBI Reference Sequences

More...
RefSeqi
XP_966031.1, XM_960938.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAG25211; CAG25211; PF3D7_0604100

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0604100.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3885840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0604100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25211.1
RefSeqiXP_966031.1, XM_960938.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiC6KSN9, 11 interactors

PTM databases

SwissPalmiC6KSN9

Proteomic databases

PRIDEiC6KSN9

Genome annotation databases

EnsemblProtistsiCAG25211; CAG25211; PF3D7_0604100
GeneDBiPF3D7_0604100.1:pep
GeneIDi3885840
KEGGipfa:PF3D7_0604100

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0604100

Phylogenomic databases

HOGENOMiCLU_236436_0_0_1
OMAiNINSEEC

Enzyme and pathway databases

BioCyciPLASMO:PFF0200C-MONOMER

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC6KSN9_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6KSN9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 22, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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