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Entry version 71 (10 Feb 2021)
Sequence version 1 (01 Sep 2009)
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Protein

Suppressor of aph-1

Gene

sao-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in negative regulation of early and late embryonic Notch signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of aph-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sao-1Imported
ORF Names:R10D12.14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
R10D12.14a ; CE40107 ; WBGene00011195 ; sao-1
R10D12.14b ; CE40108 ; WBGene00011195 ; sao-1
R10D12.14c ; CE12698 ; WBGene00011195 ; sao-1
R10D12.14d ; CE43865 ; WBGene00011195 ; sao-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Partially penetrant phenotypes when temperature elevated to 25 degrees Celsius which include embryonic lethality, reduced brood size, egg retention and an increased incidence of males.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59L → F in ik1; temperature-sensitive mutant with low incidence of embryonic lethality. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004337801 – 245Suppressor of aph-1CuratedAdd BLAST245

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
C6KRN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
C6KRN1

PeptideAtlas

More...
PeptideAtlasi
C6KRN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011195, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C6KRN1, 3 interactors

Molecular INTeraction database

More...
MINTi
C6KRN1

STRING: functional protein association networks

More...
STRINGi
6239.R10D12.14c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 60GYFPROSITE-ProRule annotationAdd BLAST49

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_078058_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C6KRN1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHTLAEW

Database of Orthologous Groups

More...
OrthoDBi
1451346at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform cImported (identifier: C6KRN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHKNGNNGPV IDTKWHYLGP DSEKYGPYMS KDMLFWLQAG YFNDGLQLKT
60 70 80 90 100
ENEPNYHTLG EWSQLLGTHP FSMPVHSLDA TIAQMNSMRP HGAMMMVPPG
110 120 130 140 150
LQNQFQPPMP MRFPPFLPMP LLHQMNQNGP PMGAQMHSQP PSEPIDAGSL
160 170 180 190 200
SHTPDSENET RLNEQTLQQP PSWLIALGLA GHGRKPHHHQ QILAHQHIPQ
210 220 230 240
MQHANVATDQ VVMKSVECQT EPVEISKEQA SRVLSELLGQ MVIIN
Length:245
Mass (Da):27,532
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA817206830A9CB66
GO
Isoform aImported (identifier: C6KRN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-180: Missing.

Show »
Length:224
Mass (Da):25,201
Checksum:i85ADE850D8B31585
GO
Isoform bImported (identifier: C6KRN1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-180: TRLNEQTLQQPPSWLIALGLA → FQ

Show »
Length:226
Mass (Da):25,476
Checksum:iC01CAFEA66B227E8
GO
Isoform dImported (identifier: C6KRN1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-180: TRLNEQTLQQPPSWLIALGLA → FQ
     224-224: E → EFQ

Show »
Length:228
Mass (Da):25,751
Checksum:iA0129CB55FF3C73E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A486WV16A0A486WV16_CAEEL
GYF domain-containing protein
sao-1 CELE_R10D12.14, R10D12.14
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A486WVM9A0A486WVM9_CAEEL
GYF domain-containing protein
sao-1 CELE_R10D12.14, R10D12.14
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057839160 – 180Missing in isoform a. CuratedAdd BLAST21
Alternative sequenceiVSP_057840160 – 180TRLNE…ALGLA → FQ in isoform b and isoform d. CuratedAdd BLAST21
Alternative sequenceiVSP_057841224E → EFQ in isoform d. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z81109 Genomic DNA Translation: CAJ85777.1
Z81109 Genomic DNA Translation: CAJ85778.1
Z81109 Genomic DNA Translation: CAZ65518.1
Z81109 Genomic DNA Translation: CAZ65519.1

NCBI Reference Sequences

More...
RefSeqi
NP_001041150.1, NM_001047685.1
NP_001041151.1, NM_001047686.2 [C6KRN1-3]
NP_001256550.1, NM_001269621.1 [C6KRN1-1]
NP_001256551.1, NM_001269622.1 [C6KRN1-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R10D12.14a.1; R10D12.14a.1; WBGene00011195 [C6KRN1-2]
R10D12.14b.1; R10D12.14b.1; WBGene00011195 [C6KRN1-3]
R10D12.14c.1; R10D12.14c.1; WBGene00011195 [C6KRN1-1]
R10D12.14d.1; R10D12.14d.1; WBGene00011195 [C6KRN1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3565237

UCSC genome browser

More...
UCSCi
R10D12.14b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81109 Genomic DNA Translation: CAJ85777.1
Z81109 Genomic DNA Translation: CAJ85778.1
Z81109 Genomic DNA Translation: CAZ65518.1
Z81109 Genomic DNA Translation: CAZ65519.1
RefSeqiNP_001041150.1, NM_001047685.1
NP_001041151.1, NM_001047686.2 [C6KRN1-3]
NP_001256550.1, NM_001269621.1 [C6KRN1-1]
NP_001256551.1, NM_001269622.1 [C6KRN1-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiC6KRN1, 3 interactors
MINTiC6KRN1
STRINGi6239.R10D12.14c

Proteomic databases

EPDiC6KRN1
PaxDbiC6KRN1
PeptideAtlasiC6KRN1

Genome annotation databases

EnsemblMetazoaiR10D12.14a.1; R10D12.14a.1; WBGene00011195 [C6KRN1-2]
R10D12.14b.1; R10D12.14b.1; WBGene00011195 [C6KRN1-3]
R10D12.14c.1; R10D12.14c.1; WBGene00011195 [C6KRN1-1]
R10D12.14d.1; R10D12.14d.1; WBGene00011195 [C6KRN1-4]
GeneIDi3565237
UCSCiR10D12.14b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3565237
WormBaseiR10D12.14a ; CE40107 ; WBGene00011195 ; sao-1
R10D12.14b ; CE40108 ; WBGene00011195 ; sao-1
R10D12.14c ; CE12698 ; WBGene00011195 ; sao-1
R10D12.14d ; CE43865 ; WBGene00011195 ; sao-1

Phylogenomic databases

eggNOGiKOG1862, Eukaryota
HOGENOMiCLU_078058_0_0_1
InParanoidiC6KRN1
OMAiFHTLAEW
OrthoDBi1451346at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:C6KRN1

Gene expression databases

BgeeiWBGene00011195, Expressed in adult organism and 5 other tissues

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAO1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6KRN1
Secondary accession number(s): C6KRN2, Q1ZXT3, Q1ZXT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 16, 2015
Last sequence update: September 1, 2009
Last modified: February 10, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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