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Protein

Piezo-type mechanosensitive ion channel component

Gene

pezo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
Gene namesi
Name:pezo-1Imported
ORF Names:C10C5.1Imported, CELE_C10C5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC10C5.1b ; CE49903 ; WBGene00007505 ; pezo-1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 45HelicalUniRule annotationAdd BLAST26
Transmembranei57 – 81HelicalUniRule annotationAdd BLAST25
Transmembranei122 – 143HelicalUniRule annotationAdd BLAST22
Transmembranei175 – 199HelicalUniRule annotationAdd BLAST25
Transmembranei211 – 229HelicalUniRule annotationAdd BLAST19
Transmembranei241 – 264HelicalUniRule annotationAdd BLAST24
Transmembranei307 – 325HelicalUniRule annotationAdd BLAST19
Transmembranei414 – 433HelicalUniRule annotationAdd BLAST20
Transmembranei439 – 459HelicalUniRule annotationAdd BLAST21
Transmembranei466 – 487HelicalUniRule annotationAdd BLAST22
Transmembranei511 – 533HelicalUniRule annotationAdd BLAST23
Transmembranei587 – 608HelicalUniRule annotationAdd BLAST22
Transmembranei614 – 631HelicalUniRule annotationAdd BLAST18
Transmembranei643 – 663HelicalUniRule annotationAdd BLAST21
Transmembranei700 – 718HelicalUniRule annotationAdd BLAST19
Transmembranei779 – 800HelicalUniRule annotationAdd BLAST22
Transmembranei806 – 821HelicalUniRule annotationAdd BLAST16
Transmembranei828 – 847HelicalUniRule annotationAdd BLAST20
Transmembranei890 – 911HelicalUniRule annotationAdd BLAST22
Transmembranei1001 – 1022HelicalUniRule annotationAdd BLAST22
Transmembranei1063 – 1082HelicalUniRule annotationAdd BLAST20
Transmembranei1123 – 1142HelicalUniRule annotationAdd BLAST20
Transmembranei1148 – 1167HelicalUniRule annotationAdd BLAST20
Transmembranei1188 – 1210HelicalUniRule annotationAdd BLAST23
Transmembranei1577 – 1601HelicalUniRule annotationAdd BLAST25
Transmembranei1613 – 1636HelicalUniRule annotationAdd BLAST24
Transmembranei1667 – 1685HelicalUniRule annotationAdd BLAST19
Transmembranei1789 – 1808HelicalUniRule annotationAdd BLAST20
Transmembranei1828 – 1850HelicalUniRule annotationAdd BLAST23
Transmembranei1859 – 1877HelicalUniRule annotationAdd BLAST19
Transmembranei2001 – 2025HelicalUniRule annotationAdd BLAST25
Transmembranei2309 – 2330HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiC6KRJ3
PeptideAtlasiC6KRJ3

Expressioni

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Structurei

3D structure databases

ProteinModelPortaliC6KRJ3
SMRiC6KRJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1202 – 1417PIEZOInterPro annotationAdd BLAST216
Domaini1940 – 2393Piezo_RRas_bdgInterPro annotationAdd BLAST454

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1306 – 1326Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029
HOGENOMiHOG000022123
InParanoidiC6KRJ3
KOiK22128

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

C6KRJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK
60 70 80 90 100
SLALPKLVGT FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT
110 120 130 140 150
TLFRSIGLVR FHPTGTFEST RAFLPEIIAT SAALLTIIIV MFLSHRDEQL
160 170 180 190 200
DVVGDVVTVR SESGREQRRQ RKLAAIMWSA IGNSLRRLTN FVLFLFTAYV
210 220 230 240 250
GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF LIFYSALHFL
260 270 280 290 300
VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
310 320 330 340 350
DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE
360 370 380 390 400
LLSNASSSAN DDEQGRARSR SPLRNGEEQG SIPLRKVTSQ VVDRNKLSNI
410 420 430 440 450
FNTPGDKESA ASKGMIAVMT FVIFHSYSIA LTAMMTWALL YHSIFGLILL
460 470 480 490 500
ILTCILWIFR DTRKSSFAMA PIILMYIEFL LILQYFLSMD IHAEIGDPAW
510 520 530 540 550
MNFVGIEWTT LPVHAVIILC VQTLLTLPVF LLLRLARREK FYESLSDYER
560 570 580 590 600
QRRINSYGTF GASKTGAGGV AVAKDPKSRK FAAFVEYLSN KVSVYFIFVV
610 620 630 640 650
SVVLLVVSTC FAPNFYNILF FALWALNLIY LKFSFRLYRG LAYAFWLTLT
660 670 680 690 700
FYTSIVIIAL YIYQFPGVSQ WIIRNTSLSQ EWLNAIGLVD FRAIGESGAL
710 720 730 740 750
FLQLLAPIAL FVVTMLQLKF FHGPWSRATS PRRAENDPPT STTEAAAVAS
760 770 780 790 800
TSGTQGRAHA AGDTLVKKLH KLANQTIELL WRFFEVHISK IVFVIIAIFI
810 820 830 840 850
ANNINALYIP LVILLSLAIC LPSAADGIFS LFMCAYLFLV ALSKMIYQLD
860 870 880 890 900
IVPELSQIDR GVGADNCSHG NISMPEWFGL KKEVEGTEPI YMLFGVIVSI
910 920 930 940 950
IALAFQSIVI YRQRHYRASL GLPESMRAKV FPDFHHSHFD RSLKNAIQFL
960 970 980 990 1000
IDYGFYKFGL EITMIAIGID IFNRMDALAA IQCFWLVLFA LNKRVFVRRI
1010 1020 1030 1040 1050
WVFYVIYMAI LYPLQFFSYV GLPPDSCIEY PWSYWIPSYS DDARFNLSYL
1060 1070 1080 1090 1100
LNLSIYGVNW PSAYLIGDFF VLLLASCQLA VFRREGEDND SIYNDGNFVI
1110 1120 1130 1140 1150
KPENPQYDFI DTKKSYVDYF KSFVFHYGHW ITLMSTLAAG IAGTSLFALG
1160 1170 1180 1190 1200
YIIFTLTMLW SGNNLYVMNS TLRSFEHTLK RWNALLGYTL FTITMKVCLQ
1210 1220 1230 1240 1250
IFGCVFLSWF DQSGGWGKTL CIVRQLFSIT CVNNECHVLK ELEDFSKACA
1260 1270 1280 1290 1300
VETKEGNIGF DVIALSFLVF QIRIFHSWYF QHCMVEYRSE VILANRGAVL
1310 1320 1330 1340 1350
KNQLIEKEMK EQNEQQKAKF NDIRRRTEAI RERYQKQIER GAAERDFEPV
1360 1370 1380 1390 1400
TYGHAKRAGD YYMFKYDPEN DDLVEPVDSF VPEVDPKATA YDRLDPGQIM
1410 1420 1430 1440 1450
YAATAHDLDL AKTVQQVKKG DTIKDPDSRA LIAVSEPEAR KPGGTEETDG
1460 1470 1480 1490 1500
DEDEDNKDSK VESTAKFIQK MIASALDLCS VTLNKLCREH RYVGFVLSKE
1510 1520 1530 1540 1550
KQKLKSGHSE SLSNTSRKLT DIRSAVDLPS LQLVQSANDV EKMETAVSVD
1560 1570 1580 1590 1600
WQQKSSATRL LNAVVNCIGA HTDILCYFFA IMTQVMTGGL ITLPLPLMSL
1610 1620 1630 1640 1650
FWGNLSNPRP SKFFWVTMIT YTECVIVIKF VCQFAFMPYN SITWRTEHQM
1660 1670 1680 1690 1700
DPMSLDKLFG VSQRDSFALW DIVLLFSLFF HRYMLRKLGL WKDANLTDTF
1710 1720 1730 1740 1750
TLKEEPRSAS GSDTGSPKKI AQEPKVVVTQ SDTLEGTSGG EIVIPSDPNA
1760 1770 1780 1790 1800
VSNMEELDCE PPIPEKQSGP IGRFIHQLFH PKFRYIRDLY PIMFGIDVIC
1810 1820 1830 1840 1850
FLIMTFGYSA FGEGGSGNVL DDVKASRIPV TLVVMLVGMT LAIIIDRALY
1860 1870 1880 1890 1900
LRKSVVGKLI YQVLMIAFLH IWVFLVLPNM TRRSAISNHV AQALYVIKSC
1910 1920 1930 1940 1950
YFLVSAWQIR NGYPELCIGN LLTHSYGMTN MIAFKVFMNI PFLFELRTAI
1960 1970 1980 1990 2000
DWTWTDTSMP LFDFFNMENF YAHIFNIKCA RQFEAAYPAP RGIPKGKLVK
2010 2020 2030 2040 2050
YMMGFPIIIG VVIFIFSPLL LWSLLNQIGT ISMPEKVTLR ISIEGYPPLY
2060 2070 2080 2090 2100
EMEAQGSNHD NAELGMIKPD QLASLNQALT DSYTTRDTNS ILRSRMSVSY
2110 2120 2130 2140 2150
LKGYTYEDIL IVRFRPESEI YWPISQDSRN AMIDKLSRNT SVNFEVSLEF
2160 2170 2180 2190 2200
TRPYDPNENA ALKHSKSWLV PISLDMTIRA KIQSALRGDP GHPILIPQSI
2210 2220 2230 2240 2250
PAFIQVPNQG ELTLPTSIGN TIINDGNPRI NTTGMEKSDE ARAWFDSLTL
2260 2270 2280 2290 2300
NLEQGKSQNE KMWIATSEHP GDQNAKLWIK TANTTYSGRP YLQVVGFIDR
2310 2320 2330 2340 2350
AFPSFLAKVF KGGVIAVYLS VILVVGRGLV RGIFTTSPST VMFTELPNAD
2360 2370 2380 2390 2400
HLLKICLDIY LVREAKDFML EQDLFAKLIF LFRSPATLIE WTRMSKKKQE
Length:2,400
Mass (Da):272,513
Last modified:September 3, 2014 - v2
Checksum:i231DCEE83F8CD238
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061ACU2A0A061ACU2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,442Annotation score:
D0VWN8D0VWN8_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:
Q17897Q17897_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,438Annotation score:
H9G2S2H9G2S2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
H9G2S3H9G2S3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:
A0A061AJB7A0A061AJB7_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,404Annotation score:
A0A061AE33A0A061AE33_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
O01260O01260_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,704Annotation score:
B9WRT3B9WRT3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,730Annotation score:
A0A061AL01A0A061AL01_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,686Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAZ65467.2
RefSeqiNP_001255390.2, NM_001268461.2

Genome annotation databases

EnsemblMetazoaiC10C5.1b; C10C5.1b; WBGene00007505
GeneIDi182492
KEGGicel:CELE_C10C5.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAZ65467.2
RefSeqiNP_001255390.2, NM_001268461.2

3D structure databases

ProteinModelPortaliC6KRJ3
SMRiC6KRJ3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiC6KRJ3
PeptideAtlasiC6KRJ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C5.1b; C10C5.1b; WBGene00007505
GeneIDi182492
KEGGicel:CELE_C10C5.1

Organism-specific databases

CTDi182492
WormBaseiC10C5.1b ; CE49903 ; WBGene00007505 ; pezo-1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029
HOGENOMiHOG000022123
InParanoidiC6KRJ3
KOiK22128

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC6KRJ3_CAEEL
AccessioniPrimary (citable) accession number: C6KRJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 3, 2014
Last modified: October 10, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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