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Entry version 70 (29 Sep 2021)
Sequence version 1 (01 Sep 2009)
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Protein
Submitted name:

Class D tetracycline/H+ antiporter

Gene

tetA

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistanceARBA annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.2.103, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Class D tetracycline/H+ antiporterImported
Submitted name:
Tetracycline efflux MFS transporter Tet(D)Imported
Submitted name:
Tetracycline efflux transporter class DImported
Submitted name:
Tetracycline resistance protein, class DImported
Submitted name:
Tetracycline resistance protein, class D (TetA(D))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tetAImported
Synonyms:tet(D)Imported, tetA (D)Imported, tetA(D)Imported
ORF Names:BMR21_26570Imported, CY655_27580Imported, EPS76_25230Imported, pRAx_0058Imported, RCS36_PI-II0038Imported, RCS70_P0014Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid RCS36_pI-IIImported
Plasmid RCS70_pImported
Plasmid p39R861-4Imported
Plasmid pE66AnImported
Plasmid pRAxImported
Plasmid pe66anImported
Plasmid rcs36_pi-iiImported
Plasmid rcs70_pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000464401 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pe66an, strain e66an
  • UP000305861 Componenti: Plasmid rcs36_pi-ii
  • UP000288730 Componenti: Unassembled WGS sequence
  • UP000284592 Componenti: Chromosome
  • UP000225496 Componenti: Unassembled WGS sequence
  • UP000308808 Componenti: Plasmid rcs70_p

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 61HelicalSequence analysisAdd BLAST20
Transmembranei73 – 96HelicalSequence analysisAdd BLAST24
Transmembranei102 – 119HelicalSequence analysisAdd BLAST18
Transmembranei131 – 152HelicalSequence analysisAdd BLAST22
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei199 – 222HelicalSequence analysisAdd BLAST24
Transmembranei242 – 267HelicalSequence analysisAdd BLAST26
Transmembranei274 – 293HelicalSequence analysisAdd BLAST20
Transmembranei299 – 320HelicalSequence analysisAdd BLAST22
Transmembranei332 – 354HelicalSequence analysisAdd BLAST23
Transmembranei366 – 384HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell inner membraneARBA annotation, Cell membrane, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 389MFSInterPro annotationAdd BLAST386

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. TCR/Tet family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR001958, Tet-R_TetA/multi-R_MdtG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01035, TCRTETA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C6G9U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKPAVIALV ITLLDAMGIG LIMPVLPSLL REYLPEADVA NHYGILLALY
60 70 80 90 100
AVMQVCFAPL LGRWSDKLGR RPVLLLSLAG AAFDYTLLAL SNVLWMLYLG
110 120 130 140 150
RIISGITGAT GAVAASVVAD STAVSERTAW FGRLGAAFGA GLIAGPAIGG
160 170 180 190 200
LAGDISPHLP FVIAAILNAC TFLMVFFIFK PAVQTEEKPA EQKQESAGIS
210 220 230 240 250
FITLLKPLAL LLFVFFTAQL IGQIPATVWV LFTESRFAWD SAAVGFSLAG
260 270 280 290 300
LGAMHALFQA VVAGALAKRL SEKTIIFAGF IADATAFLLM SAITSGWMVY
310 320 330 340 350
PVLILLAGGG IALPALQGII SAGASAANQG KLQGVLVSLT NLTGVAGPLL
360 370 380 390
FAFIFSQTQQ SADGTVWLIG TALYGLLLAI CLLIRKPAPV AATC
Length:394
Mass (Da):41,049
Last modified:September 1, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8962FE0382301D6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ705806 Genomic DNA Translation: ACN66874.1
KP276584 Genomic DNA Translation: AJT60275.1
CP025573 Genomic DNA Translation: AZZ29504.1
HF545433 Genomic DNA Translation: CCN79917.1
MPHZ01000094 Genomic DNA Translation: PGF72507.1
SCJN01000359 Genomic DNA Translation: RXD08105.1
LT985229 Genomic DNA Translation: SPD96724.1
LT985275 Genomic DNA Translation: SPE01363.1

NCBI Reference Sequences

More...
RefSeqi
WP_001039466.1, NZ_WSXE01000114.1
YP_002995713.1, NC_012886.1
YP_007349484.1, NC_020086.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AZZ29504; AZZ29504; CY655_27580

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59690035

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ705806 Genomic DNA Translation: ACN66874.1
KP276584 Genomic DNA Translation: AJT60275.1
CP025573 Genomic DNA Translation: AZZ29504.1
HF545433 Genomic DNA Translation: CCN79917.1
MPHZ01000094 Genomic DNA Translation: PGF72507.1
SCJN01000359 Genomic DNA Translation: RXD08105.1
LT985229 Genomic DNA Translation: SPD96724.1
LT985275 Genomic DNA Translation: SPE01363.1
RefSeqiWP_001039466.1, NZ_WSXE01000114.1
YP_002995713.1, NC_012886.1
YP_007349484.1, NC_020086.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.1.2.103, the major facilitator superfamily (mfs)

Genome annotation databases

EnsemblBacteriaiAZZ29504; AZZ29504; CY655_27580
GeneIDi59690035

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR001958, Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
PRINTSiPR01035, TCRTETA
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC6G9U4_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C6G9U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: September 29, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported
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