Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 41HelicalUniRule annotationAdd BLAST29
Transmembranei492 – 515HelicalUniRule annotationAdd BLAST24
Transmembranei658 – 685HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 133GP120InterPro annotationAdd BLAST101
Domaini134 – 491GP120InterPro annotationAdd BLAST358
Domaini510 – 700GP41InterPro annotationAdd BLAST191

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909 HIV-1-like_HR1-HR2, 1 hit
Gene3Di2.170.40.20, 2 hits
HAMAPiMF_04083 HIV_ENV, 1 hit
InterProiView protein in InterPro
IPR036377 Gp120_core_sf
IPR037527 Gp160
IPR000328 GP41-like
IPR000777 HIV1_Gp120
PfamiView protein in Pfam
PF00516 GP120, 2 hits
PF00517 GP41, 1 hit
SUPFAMiSSF56502 SSF56502, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6FYE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRGILRNY QQWWIWGILG FWMLMTCSMV GSLWVTVYYG VPVWKEAKTT
60 70 80 90 100
LFCASDAKAY EREVHNVWAT HACVPTDPNP QEMVLENVTE HFNIWKNDMV
110 120 130 140 150
DQMHEDIISL WDQSLKPCVK LTPLCVTLNC TNTNEEMKNC SFNATTEIRD
160 170 180 190 200
KKQKAYALFY RLDIVPLDTK NPRNKSTNSS GEYILINCNT STITQACPKV
210 220 230 240 250
SFDPIPIHYC APAGYAILKC NNKTFSGIGP CNNVSTVTCT HGIKPVVSTQ
260 270 280 290 300
LLLNGSLAEG EIIIRSENLT NDVKTIIVHL NESVQINCTR PGNNTRKSIR
310 320 330 340 350
IGPGQTFYAH GIIGDIKQAH CNISRWQWNK TLQQVKQKLE EHFPNKTIEF
360 370 380 390 400
APHAGGDLEI TTHSFNCRGE FFYCNTSPLF NSTYDLNGTA STITLQCKIK
410 420 430 440 450
QIINMWQGVG KAMYAPPIEG NITCNSSITG LLLTRDGGTR DRNDTETFRP
460 470 480 490 500
GGGDMRDNWR SELYKYKVVE IKPLGIAPTE AKRRVVEREK RAVGIGAVFL
510 520 530 540 550
GILGAAGSTM GAASITLTVQ ARQLLSGIVQ QQNNLLRAIE AQQHMLQLTV
560 570 580 590 600
WGIKQLQARV LAIERYLKDQ QLLGIWGCSG KLICTTDVPW NSSWSNKTKA
610 620 630 640 650
DIWDKMTWMQ WDREISNYTD TIYELLEKSQ IQQANNEKEL LALDSWNNLW
660 670 680 690 700
NWFDISKWLW YIKIFIMIVG GLIGLRIIFA VLSIVNRVRQ GYSPLSFQIL
710 720 730 740 750
TPNPRGPDRL GRIEEEGGEQ DRDRSVRLVS GFLALTWDDL RSLCLFCYHL
760 770 780 790 800
LRDFLLVAAR AVELLGRSSL RGLQRGWEVL KYLGSLVQYW GLELKKSAIS
810 820 830 840
LLDTIAIAVA EGTDRIIVLV QRFCGAIRNI PRRIRQGFEA SLL
Length:843
Mass (Da):95,551
Last modified:September 1, 2009 - v1
Checksum:iFB349B744232607B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ443601 Genomic DNA Translation: ACS67314.1
FJ443604 Genomic DNA Translation: ACS67317.1
FJ443605 Genomic DNA Translation: ACS67318.1
FJ443607 Genomic DNA Translation: ACS67319.1
FJ443614 Genomic DNA Translation: ACS67325.1
FJ443617 Genomic DNA Translation: ACS67327.1
FJ443618 Genomic DNA Translation: ACS67328.1
FJ443620 Genomic DNA Translation: ACS67330.1
FJ443621 Genomic DNA Translation: ACS67331.1
FJ443623 Genomic DNA Translation: ACS67333.1

Similar proteinsi

Entry informationi

Entry nameiC6FYE5_9HIV1
AccessioniPrimary (citable) accession number: C6FYE5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 18, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health