Natriuretic and helokinestatin peptides precursor - Heloderma suspectum cinctum (Banded Gila monster)

Functionⁱ

Helokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2), with helokinestatin-1 being the most potent antagonist.1 Publication

GO - Molecular functionⁱ

hormone activity Source: InterPro
toxin activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of blood pressure Source: UniProtKB-KW
regulation of blood vessel size Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Hypotensive agent, Toxin, Vasoactive

Molecular function

Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Hypotensive agent, Toxin, Vasoactive

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Natriuretic and helokinestatin peptides1 Publication Cleaved into the following 5 chains: Helokinestatin-11 Publication Short name: HKS-11 Publication Helokinestatin-21 Publication Short name: HKS-21 Publication Helokinestatin-31 Publication Short name: HKS-31 Publication Helokinestatin-41 Publication Short name: HKS-41 Publication Natriuretic peptide1 Publication
Organismⁱ	Heloderma suspectum cinctum (Banded Gila monster)
Taxonomic identifierⁱ	537493 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Anguimorpha › Neoanguimorpha › Helodermatidae › Heloderma › Heloderma suspectum

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST	25
PropeptideⁱPRO_0000392454	26 – 58	1 PublicationAdd BLAST	33
PeptideⁱPRO_0000392455	59 – 68	Helokinestatin-11 Publication	10
PropeptideⁱPRO_0000392456	69 – 73	1 Publication	5
PeptideⁱPRO_0000392457	74 – 84	Helokinestatin-21 PublicationAdd BLAST	11
PropeptideⁱPRO_0000392458	85 – 89	1 Publication	5
PeptideⁱPRO_0000392459	90 – 102	Helokinestatin-31 PublicationAdd BLAST	13
PropeptideⁱPRO_0000392460	103 – 112	1 Publication	10
PeptideⁱPRO_0000392461	113 – 122	Helokinestatin-41 Publication	10
PropeptideⁱPRO_0000392462	123 – 146	1 PublicationAdd BLAST	24
PeptideⁱPRO_0000392463	147 – 178	Natriuretic peptide1 PublicationAdd BLAST	32

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	153 ↔ 169	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Interactionⁱ

GO - Molecular functionⁱ

hormone activity Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	C6EVG7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

In the C-terminal section; belongs to the natriuretic peptide family.Sequence analysis

Keywords - Domainⁱ

Signal

Family and domain databases

InterProⁱ	View protein in InterPro IPR000663 Natr_peptide IPR030480 Natr_peptide_CS IPR002408 Natriuretic_peptide_brain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00212 ANP, 1 hit
PRINTSⁱ	PR00712 BNATPEPTIDE
SMARTⁱ	View protein in SMART SM00183 NAT_PEP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

C6EVG7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPRLACSTW LPLLLVLFTL DQGRANPVER GQEYRSLSKR FDDDSTELIL 
        60         70         80         90        100
EPRASEENGP PYQPLVPRAS DENVPPAYVP LVPRASDENV PPPPLQMPLI 
       110        120        130        140        150
PRASEQKGPP FNPPPFVDYE PRAANENALR KLIKRSFERS PGRNKRLSPG 
       160        170 
DGCFGQKIDR IGAVSGMGCN SVSSQGKK

Length:178

Mass (Da):19,672

Last modified:September 1, 2009 - v1

Checksum:ⁱ2B0F1F9895FBA88F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU790965 mRNA Translation: ACE95067.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

EU790965 mRNA Translation: ACE95067.1

Protein	Similar proteins		Species	Score	Length	Source
C6EVG7	Preprohelokinestatin-2 protein		HELSU		178	UniRef100_C6EVG7

Protein	Similar proteins		Species	Score	Length	Source
C6EVG7	Preprohelokinestatin-2 protein		HELSU		178	UniRef90_C6EVG7
Preprohelokinestatin-3		HELHR		196

Protein	Similar proteins		Species	Score	Length	Source
C6EVG7	Preprohelokinestatin-2 protein		HELSU		178	UniRef50_C6EVG7
Preprohelokinestatin-3		HELHR		196
Preprohelokinestatin-1 protein		HELSU		177

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU790965 mRNA Translation: ACE95067.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

EU790965 mRNA Translation: ACE95067.1

3D structure databases

SMRⁱ	C6EVG7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

InterProⁱ	View protein in InterPro IPR000663 Natr_peptide IPR030480 Natr_peptide_CS IPR002408 Natriuretic_peptide_brain
Pfamⁱ	View protein in Pfam PF00212 ANP, 1 hit
PRINTSⁱ	PR00712 BNATPEPTIDE
SMARTⁱ	View protein in SMART SM00183 NAT_PEP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00263 NATRIURETIC_PEPTIDE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VNHP_HELSC
Accessionⁱ	C6EVG7Primary (citable) accession number: C6EVG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 23, 2010
	Last sequence update:	September 1, 2009
	Last modified:	November 22, 2017
	This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program
Annotation program	Chordata Protein Annotation Program

UniProtKB - C6EVG7 (VNHP_HELSC)

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Natriuretic and helokinestatin peptides

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

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Annotation systems

Supporting data

UniProtKB - C6EVG7 (VNHP_HELSC)

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Natriuretic and helokinestatin peptides

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ