UniProtKB - C6EVG7 (VNHP_HELSC)
Protein
Natriuretic and helokinestatin peptides
Gene
N/A
Organism
Heloderma suspectum cinctum (Banded Gila monster)
Status
Functioni
Helokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2), with helokinestatin-1 being the most potent antagonist.1 Publication
Natriuretic peptide exhibits vasoactive properties and induces hypotension, possibly by binding to natriuretic peptide receptor NPR1.1 Publication
GO - Molecular functioni
- hormone activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of blood pressure Source: UniProtKB-KW
Keywordsi
Molecular function | Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Hypotensive agent, Toxin, Vasoactive |
Names & Taxonomyi
Protein namesi | Recommended name: Natriuretic and helokinestatin peptides1 PublicationCleaved into the following 5 chains: Natriuretic peptide1 Publication |
Organismi | Heloderma suspectum cinctum (Banded Gila monster) |
Taxonomic identifieri | 537493 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Anguimorpha › Neoanguimorpha › Helodermatidae › Heloderma › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000392454 | 26 – 58 | 1 PublicationAdd BLAST | 33 | |
PeptideiPRO_0000392455 | 59 – 68 | Helokinestatin-11 Publication | 10 | |
PropeptideiPRO_0000392456 | 69 – 73 | 1 Publication | 5 | |
PeptideiPRO_0000392457 | 74 – 84 | Helokinestatin-21 PublicationAdd BLAST | 11 | |
PropeptideiPRO_0000392458 | 85 – 89 | 1 Publication | 5 | |
PeptideiPRO_0000392459 | 90 – 102 | Helokinestatin-31 PublicationAdd BLAST | 13 | |
PropeptideiPRO_0000392460 | 103 – 112 | 1 Publication | 10 | |
PeptideiPRO_0000392461 | 113 – 122 | Helokinestatin-41 Publication | 10 | |
PropeptideiPRO_0000392462 | 123 – 146 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_0000392463 | 147 – 178 | Natriuretic peptide1 PublicationAdd BLAST | 32 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 153 ↔ 169 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Sequence similaritiesi
In the C-terminal section; belongs to the natriuretic peptide family.Sequence analysis
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR000663, Natr_peptide IPR030480, Natr_peptide_CS IPR002408, Natriuretic_peptide_brain |
Pfami | View protein in Pfam PF00212, ANP, 1 hit |
PRINTSi | PR00712, BNATPEPTIDE |
SMARTi | View protein in SMART SM00183, NAT_PEP, 1 hit |
PROSITEi | View protein in PROSITE PS00263, NATRIURETIC_PEPTIDE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
C6EVG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPRLACSTW LPLLLVLFTL DQGRANPVER GQEYRSLSKR FDDDSTELIL
60 70 80 90 100
EPRASEENGP PYQPLVPRAS DENVPPAYVP LVPRASDENV PPPPLQMPLI
110 120 130 140 150
PRASEQKGPP FNPPPFVDYE PRAANENALR KLIKRSFERS PGRNKRLSPG
160 170
DGCFGQKIDR IGAVSGMGCN SVSSQGKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU790965 mRNA Translation: ACE95067.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU790965 mRNA Translation: ACE95067.1 |
3D structure databases
SMRi | C6EVG7 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000663, Natr_peptide IPR030480, Natr_peptide_CS IPR002408, Natriuretic_peptide_brain |
Pfami | View protein in Pfam PF00212, ANP, 1 hit |
PRINTSi | PR00712, BNATPEPTIDE |
SMARTi | View protein in SMART SM00183, NAT_PEP, 1 hit |
PROSITEi | View protein in PROSITE PS00263, NATRIURETIC_PEPTIDE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VNHP_HELSC | |
Accessioni | C6EVG7Primary (citable) accession number: C6EVG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 23, 2010 |
Last sequence update: | September 1, 2009 | |
Last modified: | February 26, 2020 | |
This is version 25 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families