Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bartonella grahamii (strain as4aup)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBGRA634504:BGR_RS00345-MONOMER
UniPathwayiUPA00034; UER00019

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotationImported
Ordered Locus Names:Bgr_00690Imported
OrganismiBartonella grahamii (strain as4aup)Imported
Taxonomic identifieri634504 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001489 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi634504.Bgr_00690

Structurei

3D structure databases

ProteinModelPortaliC6AB89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 72THDPS_N_2InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
HOGENOMiHOG000003295
KOiK00674
OMAiQVPCALI
OrthoDBiPOG091H0G02

Family and domain databases

Gene3Di1.10.166.10, 1 hit
HAMAPiMF_00811 DapD, 1 hit
InterProiView protein in InterPro
IPR005664 DapD_Trfase_Hexpep_rpt_fam
IPR001451 Hexapep
IPR023180 THP_succinylTrfase_dom1
IPR037133 THP_succinylTrfase_N_sf
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF14602 Hexapep_2, 1 hit
PF14805 THDPS_N_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR00965 dapD, 1 hit

Sequencei

Sequence statusi: Complete.

C6AB89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLTQLEMI IQQAFDDRDS IDTTTKGEIR ESIEHTLNLL DKGEIRVAER
60 70 80 90 100
QKNGQWHVHQ WLKKAVLLSF RLNPMQIITG GINGTHWWDK VPSKFSGWQE
110 120 130 140 150
ADFKSADFRS VPGAIVRHSA YIAPNVILMP SFVNLGAFID EGTMVDTWTT
160 170 180 190 200
VGSCAQIGKH VHLSGGVGIG GVLEPLQANP TIIEDHCFIG ARSEIVEGCI
210 220 230 240 250
IREGTVLGMG VFIGKSTKII DRTTGEIFIG EVPAYSVVVP GSFPGKPLPN
260 270 280
GEAGPSLYCA VIVKRVDQKT REKTSINDLL RS
Length:282
Mass (Da):30,944
Last modified:September 1, 2009 - v1
Checksum:iED1DB67019F03410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001562 Genomic DNA Translation: ACS50456.1
RefSeqiWP_012754494.1, NC_012846.1

Genome annotation databases

EnsemblBacteriaiACS50456; ACS50456; Bgr_00690
KEGGibgr:Bgr_00690

Entry informationi

Entry nameiC6AB89_BARGA
AccessioniPrimary (citable) accession number: C6AB89
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 18, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health