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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciTSIB604354:G1GV3-564-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:TSIB_0565
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002050831 – 249DNA polymerase sliding clampAdd BLAST249

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_0565

Structurei

3D structure databases

ProteinModelPortaliC6A1Y5
SMRiC6A1Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

C6A1Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEIVFDGA KEFADLIDTA SNLIDEAAFK IAEEGMSMRA MDPSRVVLLD
60 70 80 90 100
LNLPASIFSK YDIDGEETVG VNMDHFKKVL KRGKGKDILV LRKGEENFLE
110 120 130 140 150
ITLEGTAKRT FRLPLIEVEE LELDLPELPF TVRAVILGEV LKEAVKDASL
160 170 180 190 200
VSDSIKFIAK ENEFIMKAEG ETQEVEIKLT LEDEGLLDLN VEEETKSAYG
210 220 230 240
VSYLADMAKG IGKADEVVLR FGNEMPLQMD YPIRDEGRLT FLLAPRVEE
Length:249
Mass (Da):27,908
Last modified:September 1, 2009 - v1
Checksum:i4395D846598B131C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA Translation: ACS89630.1
RefSeqiWP_015848850.1, NC_012883.1

Genome annotation databases

EnsemblBacteriaiACS89630; ACS89630; TSIB_0565
GeneIDi8095553
KEGGitsi:TSIB_0565

Similar proteinsi

Entry informationi

Entry nameiPCNA_THESM
AccessioniPrimary (citable) accession number: C6A1Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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