UniProtKB - C5MK56 (C5MK56_HUMAN)
Protein
Submitted name:
HLA-B*3507
Gene
HLA-B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- antigen processing and presentation Source: InterPro
- immune response Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: HLA-B*3507ImportedSubmitted name: HLA-B35 variantImportedSubmitted name: MHC class I antigenImported |
Gene namesi | Name:HLA-BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 306 – 330 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5015088000 | 25 – 362 | Sequence analysisAdd BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 125 ↔ 188 | Combined sources | ||
Disulfide bondi | 227 ↔ 283 | Combined sources |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationStructurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 295 | Ig-likeInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 362 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 339 – 362 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the MHC class I family.UniRule annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
C5MK56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQR RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04696 mRNA Translation: AAA52674.1 GQ119001 Genomic DNA Translation: ACR81574.1 KY419481 Genomic DNA Translation: ASU50372.1 MG553973 Genomic DNA Translation: AUQ35630.1 MG553974 Genomic DNA Translation: AUQ35631.1 MG905199 Genomic DNA Translation: AYE21463.1 MK005625 Genomic DNA Translation: AZL48696.1 MK353270 Genomic DNA Translation: AZU90269.1 Z22651 mRNA Translation: CAA80366.1 MK689951 Genomic DNA Translation: QCQ66868.1 MN003166 Genomic DNA Translation: QDK62695.1 MN003173 Genomic DNA Translation: QDK62702.1 MN003225 Genomic DNA Translation: QDK62754.1 MN003227 Genomic DNA Translation: QDK62756.1 MN016407 Genomic DNA Translation: QDK63102.1 LS999254 Genomic DNA Translation: VAV80976.1 LS999387 Genomic DNA Translation: VAV81109.1 LR537262 Genomic DNA Translation: VGN35642.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04696 mRNA Translation: AAA52674.1 GQ119001 Genomic DNA Translation: ACR81574.1 KY419481 Genomic DNA Translation: ASU50372.1 MG553973 Genomic DNA Translation: AUQ35630.1 MG553974 Genomic DNA Translation: AUQ35631.1 MG905199 Genomic DNA Translation: AYE21463.1 MK005625 Genomic DNA Translation: AZL48696.1 MK353270 Genomic DNA Translation: AZU90269.1 Z22651 mRNA Translation: CAA80366.1 MK689951 Genomic DNA Translation: QCQ66868.1 MN003166 Genomic DNA Translation: QDK62695.1 MN003173 Genomic DNA Translation: QDK62702.1 MN003225 Genomic DNA Translation: QDK62754.1 MN003227 Genomic DNA Translation: QDK62756.1 MN016407 Genomic DNA Translation: QDK63102.1 LS999254 Genomic DNA Translation: VAV80976.1 LS999387 Genomic DNA Translation: VAV81109.1 LR537262 Genomic DNA Translation: VGN35642.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JRX | X-ray | 2.30 | A | 25-300 | [»] | |
4JRY | X-ray | 2.80 | A | 25-300 | [»] | |
4PRA | X-ray | 1.85 | A | 25-300 | [»] | |
4PRB | X-ray | 1.75 | A | 25-300 | [»] | |
4PRD | X-ray | 1.75 | A | 25-300 | [»] | |
4PRE | X-ray | 1.65 | A | 25-300 | [»] | |
4PRH | X-ray | 2.50 | A | 26-299 | [»] | |
4PRI | X-ray | 2.40 | A | 25-300 | [»] | |
4PRP | X-ray | 2.50 | A | 25-300 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
ChiTaRSi | HLA-B, human |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C5MK56_HUMAN | |
Accessioni | C5MK56Primary (citable) accession number: C5MK56 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 28, 2009 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |