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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei183PROSITE-ProRule annotation1
Active sitei393PROSITE-ProRule annotation1
Active sitei451PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CTRG_04891
OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Taxonomic identifieri294747 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002037 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 564LumenalSequence analysisAdd BLAST547
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 707CytoplasmicSequence analysisAdd BLAST122

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000041191118 – 707Pheromone-processing carboxypeptidase KEX1Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi294747.XP_002550593.1

Structurei

3D structure databases

SMRiC5MFP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5MFP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSVFIILI NTLFVLAIPP KEGSDNNPSK KYLVTDLPGL YENVKPKISV
60 70 80 90 100
PLMFSGQLEL YPENNTHYFF WKFVDSELNQ DTSKKTIFWL NGGPGCSSMD
110 120 130 140 150
GALLETGPFR IDENEKVIYN NGSWHKFGDI IYVDQPAGTG FSFTNEYITD
160 170 180 190 200
LDQVAWYFLK FMEEYYKLFP NEINNEIYFA GESYAGQYIP YIADAILKRN
210 220 230 240 250
KNLKENDVKY DLKGILIGNG WVSPNQQSLS YLPFFINHGL IDKSHPRWGS
260 270 280 290 300
LLSKHEKCQK IVNKIDGHFD EADVHPYEVN SATCESILTD LLNYSQDRES
310 320 330 340 350
DSDHRCINMY DYTLRDSYPS CGMNWPFELK YVAPFLRKEE VMHDLNLVDL
360 370 380 390 400
KYWRECSGKV GRMFGARNSL PAVHLLPNIS QEIPIILFNG ANDIICNSDG
410 420 430 440 450
VLSYLDKLQW GGKVGFTNKD DQINWIYDNK EVGYILMERN ISFINIYNSS
460 470 480 490 500
HMVPYDLPDV SRALMDLVSG KYEEKEKDGK REFITYPLGE VRNKLGQEIP
510 520 530 540 550
ADESSKPIED KPDDKPIEDK PEETKPEQTK PEDETSSSTS EIIPTSEASF
560 570 580 590 600
IPEPEESTSS KFTRLIQLGV IFIIFWGVYI LYVSYRARPS SIIKKPARST
610 620 630 640 650
NSSGRKKNVQ WADQLNRFEE DENELGSPPP QGIIAKTISK ITGNTSNRGR
660 670 680 690 700
YAPAGDGSRE FTDDIELGEG ISDPNVDEFI IGSDDDEDDD EDVETHEGNP

KKTESKS
Length:707
Mass (Da):80,574
Last modified:July 28, 2009 - v1
Checksum:i1858B0F08F8E0492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692401 Genomic DNA Translation: EER31161.1
RefSeqiXP_002550593.1, XM_002550547.1

Genome annotation databases

EnsemblFungiiEER31161; EER31161; CTRG_04891
GeneIDi8298894
KEGGictp:CTRG_04891

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692401 Genomic DNA Translation: EER31161.1
RefSeqiXP_002550593.1, XM_002550547.1

3D structure databases

SMRiC5MFP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi294747.XP_002550593.1

Protein family/group databases

MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEER31161; EER31161; CTRG_04891
GeneIDi8298894
KEGGictp:CTRG_04891

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_CANTT
AccessioniPrimary (citable) accession number: C5MFP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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