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Protein

RNA polymerase II transcription factor B subunit 2

Gene

CTRG_00586

Organism
Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:CTRG_00586Imported
OrganismiCandida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)Imported
Taxonomic identifieri294747 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002037 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi294747.XP_002545805.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

C5M3E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAHLFKATV NEYLEGLPKT VQSKLYEAPA TCLSIFRLLS PMAKFYIMSM
60 70 80 90 100
IFNEKPIALR DLDKWCKPSA RKLEFEALKR LESLHLIEYD SKGSHIRLHS
110 120 130 140 150
TFRKNFRDCL TGSQNPNAFG SISTTADKYK VDIAFLDNFA SSKWETILHF
160 170 180 190 200
MVGTEATATP SDSVLSLLKL GGLMEGPNNK LRITNSGFQF LLQDVNAQIW
210 220 230 240 250
TLLLQYLNLT QELNMDPVDV LNFIFVLGSL ELGKSYAVST LSETQVSMLA
260 270 280 290 300
DLKDYGLVYQ RSDTSGRFYP TRLATTLTSD SAALKTPAMA MDEEEQQVVT
310 320 330 340 350
KESIIIETNF KLYAYTKSPL EIAILNLFVQ LKTRFANMVC GQITRESIRN
360 370 380 390 400
ALYNGITADQ IIKFLETHAH SQMRILAKEK LDKKIEFDTS HNINTAGGAP
410 420 430 440 450
QSKTDGSISQ HKLEILPPNV VDQIKLWQLE LDRIQTFDGY LFKDFANQQE
460 470 480 490
YDILSNYASE LGVLIWADKV KRKFFVTKDG MTQVADFANR KLKR
Length:494
Mass (Da):56,013
Last modified:July 28, 2009 - v1
Checksum:i734DDBBA58585650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG692395 Genomic DNA Translation: EER35847.1
RefSeqiXP_002545805.1, XM_002545759.1

Genome annotation databases

EnsemblFungiiEER35847; EER35847; CTRG_00586
GeneIDi8296158
KEGGictp:CTRG_00586

Similar proteinsi

Entry informationi

Entry nameiC5M3E7_CANTT
AccessioniPrimary (citable) accession number: C5M3E7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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