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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185By similarity1
Active sitei387By similarity1
Active sitei449By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:BDBG_03944
OrganismiBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
Taxonomic identifieri559298 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
Proteomesi
  • UP000002038 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 520LumenalSequence analysisAdd BLAST487
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 638CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000041189834 – 638Pheromone-processing carboxypeptidase KEX1Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiC5JN54

Interactioni

Protein-protein interaction databases

STRINGi559298.XP_002625885.1

Structurei

3D structure databases

SMRiC5JN54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi564 – 569Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5JN54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG
60 70 80 90 100
PLVKMHAGHI EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR VTDDHMLNRT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV
160 170 180 190 200
SELDEMTSQF VTFMEKWFEL FPHYEKDDLY FAGESYAGQY IPYIARAILD
210 220 230 240 250
RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY REGIIQGGTD
260 270 280 290 300
ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM
310 320 330 340 350
YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS
360 370 380 390 400
GAVGGNFRAL KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK
410 420 430 440 450
DMKWSGGTGF ELSPGVWAPR QDWTFEGDSA GFYQQARNLT YVLFYNASHM
460 470 480 490 500
VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD SRIGGEKGPT TSVGGHPNST
510 520 530 540 550
TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI WRSRRQKLRN
560 570 580 590 600
SSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERLSR
610 620 630
AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRGLVDKS
Length:638
Mass (Da):71,434
Last modified:July 28, 2009 - v1
Checksum:iD15DE8A8310A0954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG657453 Genomic DNA Translation: OAT07936.1
RefSeqiXP_002625885.1, XM_002625839.1

Genome annotation databases

EnsemblFungiiOAT07936; OAT07936; BDBG_03944
GeneIDi8505374

Similar proteinsi

Entry informationi

Entry nameiKEX1_BLAGS
AccessioniPrimary (citable) accession number: C5JN54
Secondary accession number(s): A0A179UIP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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