Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptorUniRule annotation
Gene namesi
Name:AVPR2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 63HelicalUniRule annotationAdd BLAST23
Transmembranei75 – 94HelicalUniRule annotationAdd BLAST20
Transmembranei114 – 135HelicalUniRule annotationAdd BLAST22
Transmembranei156 – 179HelicalUniRule annotationAdd BLAST24
Transmembranei204 – 228HelicalUniRule annotationAdd BLAST25
Transmembranei273 – 295HelicalUniRule annotationAdd BLAST23
Transmembranei307 – 327HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000047138 Expressed in 4 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiC5HF06 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC5HF06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 324G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST271

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
KOiK04228
OMAiHIFIGHL
OrthoDBiEOG091G0DB6

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

C5HF06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFMASTTSAV PWHLSQPTPA GNGSEGELLT ARDPLLAQAE LALLSTVFVA
60 70 80 90 100
VALSNGLVLG ALVRRGRRGR WAPMHVFIGH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAHRH
160 170 180 190 200
GGGTHWNRPV LLAWAFSLLF SLPQLFIFAQ RDVDGSGVLD CWARFAEPWG
210 220 230 240 250
LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHASLGPGPV PRAGGPRRGC
260 270 280 290 300
RPGSPAEGAR VSAAVAKTVK MTLVIVIVYV LCWAPFFLVQ LWAAWDPEAP
310 320 330 340 350
REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CTWRRAPPSP
360 370
GPQEESCATA SSFLAKDTPS
Length:370
Mass (Da):40,236
Last modified:July 28, 2009 - v1
Checksum:i5FDCCC2CD21DD4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ411193 Genomic DNA Translation: ACR39007.1
RefSeqiNP_776671.1, NM_174246.2
UniGeneiBt.98

Genome annotation databases

GeneIDi281642
KEGGibta:281642

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ411193 Genomic DNA Translation: ACR39007.1
RefSeqiNP_776671.1, NM_174246.2
UniGeneiBt.98

3D structure databases

ProteinModelPortaliC5HF06
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281642
KEGGibta:281642

Organism-specific databases

CTDi554

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
KOiK04228
OMAiHIFIGHL
OrthoDBiEOG091G0DB6

Gene expression databases

BgeeiENSBTAG00000047138 Expressed in 4 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiC5HF06 baseline and differential

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC5HF06_BOVIN
AccessioniPrimary (citable) accession number: C5HF06
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again