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Entry version 75 (26 Feb 2020)
Sequence version 1 (28 Jul 2009)
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Protein
Submitted name:

Plexin B2

Gene

plxnb2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Plexin B2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plxnb2aImported
Synonyms:plxnB2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-8917 plxnb2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1225 – 1247HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500295051221 – 1864Sequence analysisAdd BLAST1844

Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 487SemaInterPro annotationAdd BLAST478

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1244 – 1271Sequence analysisAdd BLAST28
Coiled coili1592 – 1612Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IN3E Eukaryota
ENOG411131Q LUCA

KEGG Orthology (KO)

More...
KOi
K06821

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C5H5I1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C5H5I1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWRALSAFS LLLCFGSSCC DDAQEQFSSP TIINNVVQDP QTGRIYLGAV
60 70 80 90 100
NGIFQLNHNL QEEGRADTGP KKDNPQCTPP ITAQCTDAKE MDNFNKLLLV
110 120 130 140 150
NSANGTLIVC GSLFRGICSL VNLNSVNKPV YYSDTKGEKT YVASTEESVT
160 170 180 190 200
VVGVISYFKD TTTNANLSVF LVGKGYGSSD SSKLISTRLL QEHGEMDVFE
210 220 230 240 250
NMVEASTVQT SAFVLRYHHD FRYTFKDNGY IYFLFSRSPG TSDSTKITFI
260 270 280 290 300
ARLCENDHHY YSYTELQLNC TVNTEQQGNT FNKVQAAYLA KPGKDLAQNI
310 320 330 340 350
VPSNLNDKVL FGVFSADEAD GRSALCMYPL SSINARFEEV IESCYTGEVL
360 370 380 390 400
EDDKPKTVYS PYNSKNEAIC KTKRDKNMVK AYICGAEFLP SPLASKPEYA
410 420 430 440 450
LAVKPIYTRN DMLTAVAVAV ENEHTVAFLG TSGADVLKVH LDPNHTDFYN
460 470 480 490 500
RIPGDRADGA VNKNLLFDST LNHLYITTGK KISKVSVQAC EQREDCHSCV
510 520 530 540 550
SQRDPYCGWC VLEGRCTRKK DCRKGDGENA WLWSPKQTCV TIQSFEPPNI
560 570 580 590 600
SCKKTDSTQV VINIPSLPSI SSPDRLECVF DGYRSQAKME DTRVTCYLPS
610 620 630 640 650
SDYIPPTPET QDFVAVPVKI TVNDKIEVAS SVFEFYNCAG VVKKSENTPC
660 670 680 690 700
IACVTSKWGC QWNIQDHTCS DKDDSAHGSH IIGNMEANLC PQFEIPEPLR
710 720 730 740 750
IPVGYKTPIT FHGKNLDIYW GKTFQIGTEL MKQVGEVTVE ADGLKYRFEG
760 770 780 790 800
YEFAYDKEPE VNVTFYIKDK DTDRKIDSTL RVVLYNCSVR REDCSLCKNA
810 820 830 840 850
HKNDSCVWCD TTKSCIYRSL CDNELHQCPP PKITDIVPRY GPMNGRISVT
860 870 880 890 900
IKGSNLGIKK EDIKKITVAK VPCIHQPERY SVSTSVVCEI GPFPSPPEDL
910 920 930 940 950
PISPSKSGPV EVLVEGERTG TSEVEFTYRD PVPEAVFPVK GPAAGGTVIT
960 970 980 990 1000
ITGQDLDSAS KDDITITVDK EPCEVLTFGH EITCRTGPYK GQKIPSDKLP
1010 1020 1030 1040 1050
VIVKYGKDTV KTVDAFEYSP DPKISEYFPQ TSFVCGGRRI LVIGSGFDQV
1060 1070 1080 1090 1100
QRATMRVLPS SDEFDVKASN VEFFQEVEKK NETTLEFLSP VVNKTYINLS
1110 1120 1130 1140 1150
LRTVIQLDNL VLNLTDFAYH PDPHFNKLKD KAITEGSIIN VNGRGFAKAM
1160 1170 1180 1190 1200
TAKEAQAFVG DESCLVTILE DDKLFLVAPS SPPKSTSRRH RRDTSSDALE
1210 1220 1230 1240 1250
LLIKFGNGEW NVGSVRFERK YEVPLYIIIP AVLIPMVLFI AVSIYCYRRK
1260 1270 1280 1290 1300
SQQAEREYEK IKNQLANLEE SVRDRCTKEF TDLMIEMEDH TSDLSEARIP
1310 1320 1330 1340 1350
FLDYKNYTDR VFFLPSKDGA NDVMITGKLD IPDNRRAIVD QALNQFSNLL
1360 1370 1380 1390 1400
NSKTFLINFI RTLEGRQEFN ARNKVYFASL LTVALHGKLE YYTDIMRTLL
1410 1420 1430 1440 1450
LELMEEYVHS KNPKLMLRRS ETVVERMLCN WMSICLYQFL KDSAGEPLYK
1460 1470 1480 1490 1500
LFKAIKHQVE KGPVDAKMKK AKYTLNDTGL LGDDVEYSIL TLQVLVHGEG
1510 1520 1530 1540 1550
PDVTPVKVLN CDTISQVKEK IIEQVYRNLP YSQRPVVDSV ALEWRPGSTG
1560 1570 1580 1590 1600
QILSDLDLTS QKEGRWKRIN TLAHYNVRDG ATLVLSRVLH TQQSFDQNMD
1610 1620 1630 1640 1650
NHEERNALLE DDKVFHLVRP ADELEEVKSK RGSMKDKATT KAITEIYLTR
1660 1670 1680 1690 1700
LLSMKGTLQQ FVDDFFRSVL CSGTVVPPAV KYFFDFLDEQ AQKHDNVDDE
1710 1720 1730 1740 1750
TIHIWKTNSL PLRFWVNILK NPHFIFDVHL TEVVDASLSV IAQTFMDACT
1760 1770 1780 1790 1800
KTEHKLTRES PSNKLLYAKE ISTYKKMVDD YYKGIRQMVP VSDQDMNTHL
1810 1820 1830 1840 1850
AEISRSHTDK LNTQAALHQL YQYASKYYDG IISSLEEDPA AQSKQLTLRL
1860
QQIAAALENK VTDL
Length:1,864
Mass (Da):209,960
Last modified:July 28, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61ADCF5A032A10F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU743740 mRNA Translation: ACI28388.1

NCBI Reference Sequences

More...
RefSeqi
NP_001155072.1, NM_001161600.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
561433

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:561433

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU743740 mRNA Translation: ACI28388.1
RefSeqiNP_001155072.1, NM_001161600.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi561433
KEGGidre:561433

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
561433
ZFINiZDB-GENE-030131-8917 plxnb2a

Phylogenomic databases

eggNOGiENOG410IN3E Eukaryota
ENOG411131Q LUCA
KOiK06821
OrthoDBi90434at2759
PhylomeDBiC5H5I1

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC5H5I1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C5H5I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 26, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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