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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190PROSITE-ProRule annotation1
Active sitei389PROSITE-ProRule annotation1
Active sitei451PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MCYG_06129
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
Proteomesi
  • UP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 522LumenalSequence analysisAdd BLAST484
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 636CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000041190039 – 636Pheromone-processing carboxypeptidase KEX1Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi554155.XP_002846260.1

Structurei

3D structure databases

SMRiC5FTV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 570Poly-Ser8

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FTV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATHKMRYN LQLVLPSNTR ARWAWLLLLL SNPAAVLAKC ASDYFVHSLP
60 70 80 90 100
GQPEGSVLKM HAGHIEIDSE HKGNLFFWHY QNRHIANRQR TVIWLNGGPG
110 120 130 140 150
CSSMDGALME VGPYRLKDDH SLVYNEGSWD EFANLLFVDQ PVGTGFSYVS
160 170 180 190 200
TDSYVHELGP MADQFIIFLD RWFKLFPEYE NDDIYLAGES YAGQYIPYIA
210 220 230 240 250
KAIVKRNEKL PANQTAWNVE GLIIGNGWIA PNEQYRSYLT YAYKEGILKE
260 270 280 290 300
SSEGAQAAEA QLSQCSSKLS EVGKFGIHID ECERVMELIL DTTKINGKCL
310 320 330 340 350
NMYDIRLDDT SDSCGMNWPP DISSVTTYLR RPDVVKALNI NEDKTTGWRE
360 370 380 390 400
CSPGVGRNLR ATESVPSIQL LPGLLEGGIP VLLFSGDKDL ICNHVGTEDL
410 420 430 440 450
IQNMKWSRGT GFELSPGVRA PRHDWVFEGL PAGVYQQARN LTYVKFYNAS
460 470 480 490 500
HMVPFDFPRR SRDMLDRFLG VDITTIGGDP ADSRIDGLKG TITSVGAHPN
510 520 530 540 550
STTAEEREKE KMKIAAWQAY YKSGEIALIV VAIAATIWGF FVWRSKRREQ
560 570 580 590 600
GGEYQGIYPN LESLSSSSLS TFRSKRRGRH DIESTSRSDE AELESLYNGP
610 620 630
EISEVLETQD GRQRELSADG SNEKASASLM VERNLR
Length:636
Mass (Da):71,407
Last modified:July 28, 2009 - v1
Checksum:i547BA0A159BB67C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995705 Genomic DNA Translation: EEQ33310.1
RefSeqiXP_002846260.1, XM_002846214.1

Genome annotation databases

EnsemblFungiiEEQ33310; EEQ33310; MCYG_06129
GeneIDi9228429

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995705 Genomic DNA Translation: EEQ33310.1
RefSeqiXP_002846260.1, XM_002846214.1

3D structure databases

SMRiC5FTV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi554155.XP_002846260.1

Protein family/group databases

MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ33310; EEQ33310; MCYG_06129
GeneIDi9228429

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_ARTOC
AccessioniPrimary (citable) accession number: C5FTV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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