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Protein

RNA polymerase II transcription factor B subunit 2

Gene

ZYRO0F11088g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Ordered Locus Names:ZYRO0F11088gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
Proteomesi
  • UP000008536 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi4956.XP_002497680.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000170529
InParanoidiC5DY86
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

C5DY86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQHLLKSS VNQYLEELPQ QIQSRLYESP ATCLAIYRLL PQLAKFFIMS
60 70 80 90 100
MVFNESAISL RDLDRWVKSS GKLQFQDAIK SMKSLHLLIP VRSNGPMLID
110 120 130 140 150
LNHTFRESFK NALTGGEVSN SFGIVMELDN DTVTTDMLDK YSADKWETIL
160 170 180 190 200
HFMVGTSLAH IPSENVLNLL KHSKLMEESN TTGEFKITNE GFQFLLQEVN
210 220 230 240 250
SQLWALLLQY LKMTEMLQMD PVDILNFIFM LGALEFSKPY STNGLSETQK
260 270 280 290 300
VMLKDMRDYG LVFQMNSNAN VFYPTRLASM LTSDPKSIRG ASGAMDSVLK
310 320 330 340 350
QNKEDVLNKS GGAGANADDD ADEIGSEGQN MQDGALIVET NFKLYSYSNS
360 370 380 390 400
PLQIAILSLF VHMKSRFSNM VTGQLTRESI RQALLNGITA DQIIAYLETH
410 420 430 440 450
AHPQMRRMAE EQLEKRLELD PNSKDPLQIL PPTVVDQIKL WQLELDRIIS
460 470 480 490 500
FEGSLYSDFE NHQEFTLLSS YAQDIGVLIW KDDRKKKFFV SKEGNSQVLD

YAKRKLKKK
Length:509
Mass (Da):57,857
Last modified:July 28, 2009 - v1
Checksum:i21F88C33AD86AC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928178 Genomic DNA Translation: CAR28747.1
RefSeqiXP_002497680.1, XM_002497635.1

Genome annotation databases

EnsemblFungiiCAR28747; CAR28747; ZYRO0F11088g
GeneIDi8205446
KEGGizro:ZYRO0F11088g

Similar proteinsi

Entry informationi

Entry nameiC5DY86_ZYGRC
AccessioniPrimary (citable) accession number: C5DY86
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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