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Protein

L-lactate dehydrogenase

Gene

KLTH0G19536g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (KLTH0G19558g), L-lactate dehydrogenase (KLTH0G19536g), L-lactate dehydrogenase (KLTH0D00440g)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0G19536gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome G

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002555876.1

Structurei

3D structure databases

ProteinModelPortaliC5DNS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 156Ldh_1_NInterPro annotationAdd BLAST139
Domaini159 – 320Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793
InParanoidiC5DNS8
KOiK00016
OrthoDBiEOG092C3G32

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

C5DNS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSIYPPAS TIKKVNPVKV AVIGVGSVGS TTAYTLLFSE MISEVVLIDI
60 70 80 90 100
NTHKAEGESM DLNHAAPSTT GSVVYVGDYS DCADAAIVII TGGANQKPGQ
110 120 130 140 150
TRMDLAATNA RILQGIIPKI VEYAPKTILL IATNPVDVLT YVSYKVSGFP
160 170 180 190 200
LNRVIGSGTL LDSARLKYHL SQHFKTSSKN VDAFIVGEHG DSSLPVWSHV
210 220 230 240 250
KISGIRLRDY CEQSQQAYDH ELFHQMFEKT RNAAYDIIER KGYTAYGIAA
260 270 280 290 300
GILRIVETIL KDGGSPLTVS TVGNYFGIEQ VALSVPTKLN RNGAHSPVDL
310 320
SFDIKEIELI KKSALQIKSV CSTLELL
Length:327
Mass (Da):35,409
Last modified:July 28, 2009 - v1
Checksum:iAD3A4D6BB8B0EB3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928171 Genomic DNA Translation: CAR25439.1
RefSeqiXP_002555876.1, XM_002555830.1

Genome annotation databases

EnsemblFungiiCAR25439; CAR25439; KLTH0G19536g
GeneIDi8294172
KEGGilth:KLTH0G19536g

Similar proteinsi

Entry informationi

Entry nameiC5DNS8_LACTC
AccessioniPrimary (citable) accession number: C5DNS8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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