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Entry version 62 (16 Oct 2019)
Sequence version 1 (28 Jul 2009)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

KLTH0G02970g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:KLTH0G02970gImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559295 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002036 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome G

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    381046.XP_002555168.1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 450RNA_pol_Rpb2_1InterPro annotationAdd BLAST413
    Domaini215 – 402RNA_pol_Rpb2_2InterPro annotationAdd BLAST188
    Domaini476 – 538RNA_pol_Rpb2_3InterPro annotationAdd BLAST63
    Domaini575 – 636RNA_pol_Rpb2_4InterPro annotationAdd BLAST62
    Domaini677 – 741RNA_pol_Rpb2_5InterPro annotationAdd BLAST65
    Domaini749 – 1120RNA_pol_Rpb2_6InterPro annotationAdd BLAST372
    Domaini1122 – 1214RNA_pol_Rpb2_7InterPro annotationAdd BLAST93

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000222962

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    C5DLS0

    KEGG Orthology (KO)

    More...
    KOi
    K03010

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EIMYNGH

    Database of Orthologous Groups

    More...
    OrthoDBi
    42570at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00653 RNA_pol_B_RPB2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR20856 PTHR20856, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    C5DLS0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSTEEFYEED PYGYEDDEAS ITAEDSWTVI SAFFREKGLV SQQLDSFNQF
    60 70 80 90 100
    INYTIQDSIV EDSTLILEQL AQHTTEADNI SRKYEISFGK IYLAKPSMTE
    110 120 130 140 150
    SDGVSHAMYP QEARLRNLTY ASGLFVEIRK RTYEAVDIPG RDLKYEVIDE
    160 170 180 190 200
    ESEMSDESKI FIGRVPIMLR SKYCLLDELT ESDLYKLKEC PFDMGGYFII
    210 220 230 240 250
    NGSEKVLIAQ ERSAGNIVQV FKKSAPSPIS HIAEIRSALE KGSRFISTLQ
    260 270 280 290 300
    VKLYGREGST NRTIKATLPY IKQDIPIVII FRALGIIPDG EILEHICYDV
    310 320 330 340 350
    NDWQMLELLK PCVEEGFVIQ DRETALDFIG RRGTALGIKK EKRIQYAKDI
    360 370 380 390 400
    LQKEFLPHIT QLEGFESRKA FFLGYMINRL LLCALDRKDQ DDRDHFGKKR
    410 420 430 440 450
    LDLAGPLLAQ LFKTLFRKLT RDILRFMQRS VEEAKDFNLK LAVKATTITA
    460 470 480 490 500
    GLKYALATGN WGEQKKAMTS RAGVSQVLNR YTYSSTLSHL RRTNTPIGRD
    510 520 530 540 550
    GKLAKPRQLH NTHWGLVCPA ETPEGQACGL VKNLSLMSCI SVGTDPLPII
    560 570 580 590 600
    TFLNEWGMEP LEDYVPHQSP DATRVFVNGV WHGIHRNPAK LVDTIRKLRR
    610 620 630 640 650
    KGDVTSEVSI VRDIREKELK IFTDAGRVYR PLFIVDENEE TGVKELKLRK
    660 670 680 690 700
    GHIRKLMMTE YQDIEGGFEE EDINYTWSSL LNEGLVEYID AEEEETILIA
    710 720 730 740 750
    MQHEDLDPTI EAADPEEELD PAKRIKAIHH SSTFTHCEIH PSMILGVAAS
    760 770 780 790 800
    IIPFPDHNQS PRNTYQSAMG KQAMGVFLTN YSVRMDTMAN ILYYPQKPLG
    810 820 830 840 850
    TTRSMEYLKF RELPAGQNAI VAIACYSGYN QEDSMIMNQS SIDRGLFRSL
    860 870 880 890 900
    FFRSYMDQEK RIGMSITESF EKPQRTNTLR MKHGTYDKLD DDGLIAPGVR
    910 920 930 940 950
    VSGDDMIIGK TTPIPPDAEE LGQRTAFHSK RDASTPLRST ENGIVDQVLI
    960 970 980 990 1000
    TTNQEGLKFV KVRVRTTKVP QIGDKFASRH GQKGTIGITY RREDMPFTAE
    1010 1020 1030 1040 1050
    GVVPDLIINP HAIPSRMTVA HLIECLLSKV AALSGNEGDA SPFTDITVDG
    1060 1070 1080 1090 1100
    ISRLLREHGY QSRGFEVMYN GHTGKKLMAQ IFFGPTYYQR LRHMVDDKIH
    1110 1120 1130 1140 1150
    ARARGPVQVL TRQPVEGRSR DGGLRFGEME RDCMIAHGAA AFLKERLMEA
    1160 1170 1180 1190 1200
    SDAFRVHICG VCGLMTVVAK LKHNQFECRG CKNKIDIYQI HIPYAAKLLF
    1210 1220
    QELMAMNIAP RLYTDRSRDF
    Length:1,220
    Mass (Da):138,514
    Last modified:July 28, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66664F8F4EC298C7
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CU928171 Genomic DNA Translation: CAR24731.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_002555168.1, XM_002555122.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    CAR24731; CAR24731; KLTH0G02970g

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8293431

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    lth:KLTH0G02970g

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CU928171 Genomic DNA Translation: CAR24731.1
    RefSeqiXP_002555168.1, XM_002555122.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi381046.XP_002555168.1

    Genome annotation databases

    EnsemblFungiiCAR24731; CAR24731; KLTH0G02970g
    GeneIDi8293431
    KEGGilth:KLTH0G02970g

    Phylogenomic databases

    HOGENOMiHOG000222962
    InParanoidiC5DLS0
    KOiK03010
    OMAiEIMYNGH
    OrthoDBi42570at2759

    Family and domain databases

    CDDicd00653 RNA_pol_B_RPB2, 1 hit
    Gene3Di2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit
    InterProiView protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold
    PANTHERiPTHR20856 PTHR20856, 1 hit
    PfamiView protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit
    PROSITEiView protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC5DLS0_LACTC
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C5DLS0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 16, 2019
    This is version 62 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
    UniProt is an ELIXIR core data resource
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