Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214By similarity1
Active sitei418By similarity1
Active sitei482By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:KLTH0G01980g
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 655LumenalSequence analysisAdd BLAST608
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21
Topological domaini677 – 745CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
ChainiPRO_000041192248 – 745Pheromone-processing carboxypeptidase KEX1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002555127.1

Structurei

3D structure databases

SMRiC5DLM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi497 – 648Asp-richAdd BLAST152

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879
InParanoidiC5DLM9
KOiK01288
OMAiNEIYFAG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5DLM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHFKYRNQT TDICNAAALD AFAMYSNYSV PLALLFALLL SFQTARALKA
60 70 80 90 100
ADEYAVSPDL IPGLSQAEDR ALVPTMHAGH IPLDENNDEH TKNYFFWKFH
110 120 130 140 150
DESGSASGPA RDTLIFWLNG GPGCSSMDGA LMESGALRID SDGKAYLNRG
160 170 180 190 200
GWHTRGDIVF VDQPAGTGFS TVASDNDYDN DLKVVSEHFV AFLRNYFQVF
210 220 230 240 250
PDDAGKQVVF AGESYAGQFI PYFARAVLDQ DEVQVNLQAL LIGNGWIDPN
260 270 280 290 300
QQSLYYIPFA VEKGLITQDD PSFSYLLKQQ ENCQNKINSK ENDRFSFKEC
310 320 330 340 350
ENILNNLLEV TRKIKDSEGK KVPSDQQCIN MYDLRLKDSY PSCGMNWPQD
360 370 380 390 400
LPNLGKFFGT EGVLEALHLD PEHVSQWHEC DDKVSNYLKN PDSRASAAIL
410 420 430 440 450
PGLLEAGLEV MLFNGDQDII CNNMGVEAVI SQMSWGGETG FSENVQLYDW
460 470 480 490 500
VYRSPENSEI TPAGFVKYDR NLTFMSVYNA SHMVPFDNAL VSRGVVDLFL
510 520 530 540 550
NDVDLVQIDG RDTLITDDVN KGKDGDASET DDTTELDCEG KDKLSEECKQ
560 570 580 590 600
LNASKGQNGE SDKDEGEKGN EEDDNDDTED GKKDAGDEKD DGEKDDDEKD
610 620 630 640 650
GDEKDGDEKD EEDDDDKDEN EKDEEDDDKD GDKPEGKNND GAEDEDDDHN
660 670 680 690 700
SGSHLAVTMI CLLVSGTIIG GLYFTFRDRF RPRLRAILVD PTNRSEASKK
710 720 730 740
TVSWAADLEQ DAADLSNPEN GAKKKGPYTS VPTQESRDSF ELDNL
Length:745
Mass (Da):82,855
Last modified:July 28, 2009 - v1
Checksum:iECAC755742FE5B2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928171 Genomic DNA Translation: CAR24690.1
RefSeqiXP_002555127.1, XM_002555081.1

Genome annotation databases

EnsemblFungiiCAR24690; CAR24690; KLTH0G01980g
GeneIDi8293386
KEGGilth:KLTH0G01980g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928171 Genomic DNA Translation: CAR24690.1
RefSeqiXP_002555127.1, XM_002555081.1

3D structure databases

SMRiC5DLM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381046.XP_002555127.1

Protein family/group databases

MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAR24690; CAR24690; KLTH0G01980g
GeneIDi8293386
KEGGilth:KLTH0G01980g

Phylogenomic databases

HOGENOMiHOG000208879
InParanoidiC5DLM9
KOiK01288
OMAiNEIYFAG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_LACTC
AccessioniPrimary (citable) accession number: C5DLM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again