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Protein

RNA polymerase II transcription factor B subunit 2

Gene

KLTH0D09790g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Ordered Locus Names:KLTH0D09790gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002553135.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000170529
InParanoidiC5DEU2
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

C5DEU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTLFKATV TEYLQELPAQ VHSRLYSSPA TCLAIYRLLP KLAKFFIMSL
60 70 80 90 100
VFNETDASLR DLDRWVKSGG KYQFNEAIKS MKSLHLLIEG NSGQPFMINL
110 120 130 140 150
NPIFRSSFRN ALTGGEVNNS FGNVVEDENE TVHTSILDQY AANKWETILH
160 170 180 190 200
FMVGTPLTQT PSRNVLSLLQ HSKLMEESSS GELQITNEGF QFLLQDANAQ
210 220 230 240 250
IWALLLQYLR LAETLQMDPV DVLNFIFMLG ALELGKAYSD TNLSDTQKIM
260 270 280 290 300
LQDMRDYGLV FQKASNTHKF YPTRLTAMLT SDTSSIRSAS GAMNSVLSQG
310 320 330 340 350
TSSSKEEAAA VAETDEETAQ VGGTTQNIPD GAVILETNFK LYSYSNSPLQ
360 370 380 390 400
IAVLSLFVHL KSRFSNMVTG QITRESIRRA LHNGITADQI IAYMETHAHP
410 420 430 440 450
QMRRLAEQTL DKKMELDPNC NEGLQILPPT VVDQIKLWQL ELDRIISYDG
460 470 480 490 500
YLFTDFENFQ EYNMLSSYAK DIGVLLWSDD KKKRFFVSQE GNSQVIDYAK

RKLKKK
Length:506
Mass (Da):57,132
Last modified:July 28, 2009 - v1
Checksum:i51ABF15EF87533B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928168 Genomic DNA Translation: CAR22697.1
RefSeqiXP_002553135.1, XM_002553089.1

Genome annotation databases

EnsemblFungiiCAR22697; CAR22697; KLTH0D09790g
GeneIDi8295374
KEGGilth:KLTH0D09790g

Similar proteinsi

Entry informationi

Entry nameiC5DEU2_LACTC
AccessioniPrimary (citable) accession number: C5DEU2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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