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UniProtKB - C5D6L9 (PRSA_GEOSW)
Protein
Foldase protein PrsA
Gene
prsA
Organism
Geobacillus sp. (strain WCH70)
Status
Functioni
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
UniRule annotationCatalytic activityi
- EC:5.2.1.8UniRule annotation
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-UniRule
GO - Biological processi
- protein folding Source: UniProtKB-UniRule
- protein transport Source: InterPro
Keywordsi
Molecular function | Isomerase, Rotamase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:prsAUniRule annotation Ordered Locus Names:GWCH70_0643 |
Organismi | Geobacillus sp. (strain WCH70) |
Taxonomic identifieri | 471223 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus › unclassified Geobacillus |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Lipid-anchor UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | UniRule annotationAdd BLAST | 18 | |
ChainiPRO_5000470097 | 19 – 276 | Foldase protein PrsAAdd BLAST | 258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 19 | N-palmitoyl cysteineUniRule annotation | 1 | |
Lipidationi | 19 | S-diacylglycerol cysteineUniRule annotation | 1 |
Keywords - PTMi
Lipoprotein, PalmitateFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 223 | PpiCUniRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the PrsA family.UniRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0760, Bacteria |
HOGENOMi | CLU_034646_6_1_9 |
OMAi | TMKGSTI |
OrthoDBi | 1838755at2 |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.10.50.40, 1 hit |
HAMAPi | MF_01145, Foldase_PrsA, 1 hit |
InterProi | View protein in InterPro IPR023059, Foldase_PrsA IPR046357, PPIase_dom_sf IPR000297, PPIase_PpiC IPR023058, PPIase_PpiC_CS IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR027304, Trigger_fact/SurA_dom_sf |
Pfami | View protein in Pfam PF05698, Trigger_C, 1 hit |
SUPFAMi | SSF109998, SSF109998, 1 hit |
PROSITEi | View protein in PROSITE PS01096, PPIC_PPIASE_1, 1 hit PS50198, PPIC_PPIASE_2, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
C5D6L9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKWMIVAAV AAVFGLSACN NGDSEVIVKT KDGNITKEEF YNEMKARVGK
60 70 80 90 100
EVIRDLVHEK VLSKKYKVTD KEIDKEIENL KEMYGTQYDL VVQQNGEKAI
110 120 130 140 150
RDMVKLDLLR QKAAMEDIKV TDKELKDYYK NYKPKIRASH ILVKDEKTAE
160 170 180 190 200
EIKTKLDKGE DFAKLAKQYS QDPGSAPNGG DLGWFGPGKM VKEFEDAAYK
210 220 230 240 250
LKVGQVSDPV KTDYGYHIIK VTDKEEKKPF NEMKEEIEFE VKQSKLDPAK
260 270
VQSKVEKLIK DAKVEIEDKD LQDVLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001638 Genomic DNA Translation: ACS23536.1 |
RefSeqi | WP_012749338.1, NC_012793.1 |
Genome annotation databases
EnsemblBacteriai | ACS23536; ACS23536; GWCH70_0643 |
KEGGi | gwc:GWCH70_0643 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001638 Genomic DNA Translation: ACS23536.1 |
RefSeqi | WP_012749338.1, NC_012793.1 |
3D structure databases
AlphaFoldDBi | C5D6L9 |
SMRi | C5D6L9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 471223.GWCH70_0643 |
Genome annotation databases
EnsemblBacteriai | ACS23536; ACS23536; GWCH70_0643 |
KEGGi | gwc:GWCH70_0643 |
Phylogenomic databases
eggNOGi | COG0760, Bacteria |
HOGENOMi | CLU_034646_6_1_9 |
OMAi | TMKGSTI |
OrthoDBi | 1838755at2 |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.10.50.40, 1 hit |
HAMAPi | MF_01145, Foldase_PrsA, 1 hit |
InterProi | View protein in InterPro IPR023059, Foldase_PrsA IPR046357, PPIase_dom_sf IPR000297, PPIase_PpiC IPR023058, PPIase_PpiC_CS IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR027304, Trigger_fact/SurA_dom_sf |
Pfami | View protein in Pfam PF05698, Trigger_C, 1 hit |
SUPFAMi | SSF109998, SSF109998, 1 hit |
PROSITEi | View protein in PROSITE PS01096, PPIC_PPIASE_1, 1 hit PS50198, PPIC_PPIASE_2, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRSA_GEOSW | |
Accessioni | C5D6L9Primary (citable) accession number: C5D6L9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | July 28, 2009 | |
Last modified: | May 25, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |