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Entry version 69 (12 Aug 2020)
Sequence version 1 (28 Jul 2009)
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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi431 – 438GTPUniRule annotation8
Nucleotide bindingi481 – 485GTPUniRule annotation5
Nucleotide bindingi535 – 538GTPUniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MLUT465515:G1GEW-695-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Mlut_07010
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri465515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000738 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10002027801 – 930Translation initiation factor IF-2Add BLAST930

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C5C9T1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
465515.Mlut_07010

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C5C9T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini422 – 596tr-type GAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni431 – 438G1By similarity8
Regioni456 – 460G2By similarity5
Regioni481 – 484G3By similarity4
Regioni535 – 538G4By similarity4
Regioni571 – 573G5By similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0532, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006301_9_1_11

KEGG Orthology (KO)

More...
KOi
K02519

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPGMMPQ

Database of Orthologous Groups

More...
OrthoDBi
347113at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10050, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00100_B, IF_2_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006847, IF2_N
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR000795, TF_GTP-bd_dom
IPR000178, TF_IF2_bacterial-like
IPR015760, TIF_IF2
IPR023115, TIF_IF2_dom3
IPR036925, TIF_IF2_dom3_sf
IPR009000, Transl_B-barrel_sf

The PANTHER Classification System

More...
PANTHERi
PTHR43381, PTHR43381, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF11987, IF-2, 1 hit
PF04760, IF2_N, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00315, ELONGATNFCT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50447, SSF50447, 2 hits
SSF52156, SSF52156, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00487, IF-2, 1 hit
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51722, G_TR_2, 1 hit
PS01176, IF2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C5C9T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVRVHELA KELGITSKEA LSTLKDLGEF VSSASSTIEP PVVKKLRSAY
60 70 80 90 100
PGAGKSAAKP GSTPAAPAAG RSAAPKPAAA PSPRAVAPTS DAGAPAPGPA
110 120 130 140 150
AGRTAATKPG VAPTPGPAAP TPAAQVPAEP KAPQPSATPG SAAPKPGAAA
160 170 180 190 200
PKPGAPRPGN NPFSPKGGSA GSRPGARPGG RGGAPRPGNN PFAPSQGMRS
210 220 230 240 250
GREDRAPRPG GPRPPAGAGG PRPGGPRPAA GAGGPRPGGP RPNPGMMPKQ
260 270 280 290 300
ITPAPQPARG RGRPGGGPGG GPGRPGGPGG RGGRGNAQGA FGRGGGPRKG
310 320 330 340 350
RKSKRAKRQE FEQQHTREIG GVKVPKGDGT TVLRLRRGAS LADFAEKIRA
360 370 380 390 400
DVADLVKVLF TLGEMASANQ SLDEETFQLL GDELGYKVQI VSPEDEDKEL
410 420 430 440 450
LEAFDIDLEA EEANEDEADL EPRPAVVTVM GHVDHGKTRL LDAIRSSNVI
460 470 480 490 500
EGEAGGITQH IGAYQVPVEH EGEQRRLTFI DTPGHEAFTA MRARGAKVTD
510 520 530 540 550
IAVLVVAADD GVMPQTVEAL NHAQSAGVPI VVAVNKIDKD TAAPDKIRGQ
560 570 580 590 600
LTEYGLVPEE YGGDTMFVDV SARNNINIDQ LLEAILLTAD AALELTANPH
610 620 630 640 650
KAARGVAIEA NLDKGRGAVV TVLVQTGTLR VGDTMVVGSA HGRVRAMFDE
660 670 680 690 700
NGNAVEAADP SRPVQVLGLS SVPRAGDSFL VTDDERTARQ IAERREAADR
710 720 730 740 750
NAQLAKRRKR ITLEDFDQAV AEGKLDTLNL IIKGDASGAV EALEDSLLKI
760 770 780 790 800
EVGEDEVQLR VIHRGVGAIT QNDVNLATVD NAIIIGFNVR PAERVADLAD
810 820 830 840 850
REGVDMRFYN VIYDAIDDIE NALKGMLKPE YEEVELGSAE VREVFRSSKW
860 870 880 890 900
GNIAGSLVRS GLIRRNAQAR LVRDGVVVSE HLRIESLRRF KEDATEVREG
910 920 930
YECGIGLGSF NDIKEGDVIE TFEMQEKPRV
Length:930
Mass (Da):97,153
Last modified:July 28, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB368998A8EF50279
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001628 Genomic DNA Translation: ACS30233.1

NCBI Reference Sequences

More...
RefSeqi
WP_012750791.1, NZ_WBMF01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACS30233; ACS30233; Mlut_07010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7984897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mlu:Mlut_07010

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|465515.4.peg.664

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001628 Genomic DNA Translation: ACS30233.1
RefSeqiWP_012750791.1, NZ_WBMF01000008.1

3D structure databases

SMRiC5C9T1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi465515.Mlut_07010

Proteomic databases

PRIDEiC5C9T1

Genome annotation databases

EnsemblBacteriaiACS30233; ACS30233; Mlut_07010
GeneIDi7984897
KEGGimlu:Mlut_07010
PATRICifig|465515.4.peg.664

Phylogenomic databases

eggNOGiCOG0532, Bacteria
HOGENOMiCLU_006301_9_1_11
KOiK02519
OMAiNPGMMPQ
OrthoDBi347113at2

Enzyme and pathway databases

BioCyciMLUT465515:G1GEW-695-MONOMER

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B, IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847, IF2_N
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR000795, TF_GTP-bd_dom
IPR000178, TF_IF2_bacterial-like
IPR015760, TIF_IF2
IPR023115, TIF_IF2_dom3
IPR036925, TIF_IF2_dom3_sf
IPR009000, Transl_B-barrel_sf
PANTHERiPTHR43381, PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF11987, IF-2, 1 hit
PF04760, IF2_N, 2 hits
PRINTSiPR00315, ELONGATNFCT
SUPFAMiSSF50447, SSF50447, 2 hits
SSF52156, SSF52156, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00487, IF-2, 1 hit
TIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722, G_TR_2, 1 hit
PS01176, IF2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2_MICLC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C5C9T1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: August 12, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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