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Protein

dTDP-4-dehydrorhamnose reductase

Gene

rfbD

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.UniRule annotation

Catalytic activityi

dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per monomer.UniRule annotation

Pathwayi: dTDP-L-rhamnose biosynthesis

This protein is involved in the pathway dTDP-L-rhamnose biosynthesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway dTDP-L-rhamnose biosynthesis and in Carbohydrate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00124

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose reductaseUniRule annotation (EC:1.1.1.133UniRule annotation)
Gene namesi
Name:rfbDImported
Ordered Locus Names:MexAM1_META1p4040Imported
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)Imported
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p4040

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 289RmlD_sub_bindInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the dTDP-4-dehydrorhamnose reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBZ Bacteria
COG1091 LUCA
HOGENOMiHOG000227712
KOiK00067
OMAiYHYSNEG

Family and domain databases

InterProiView protein in InterPro
IPR005913 dTDP_dehydrorham_reduct
IPR036291 NAD(P)-bd_dom_sf
IPR029903 RmlD-like-bd
PANTHERiPTHR10491 PTHR10491, 1 hit
PfamiView protein in Pfam
PF04321 RmlD_sub_bind, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01214 rmlD, 1 hit

Sequencei

Sequence statusi: Complete.

C5B1A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDILILGGAG QVGTELQALS WPEGVRVHAP DRQNLDITDE AAVAAALDAR
60 70 80 90 100
AYAAVINTAA YTAVDKAETE VAAAWRLNAL APALLAAETK RRAIPLVHVS
110 120 130 140 150
TDYVFDGSGE GFYAPDAPVN PQSVYGASKA AGEMAVRSGN PRHAIVRTAW
160 170 180 190 200
VVSPHRGNFV KTMLRLANER DRLTVVDDQH GCPTSAAYLA GALAAIALRL
210 220 230 240 250
AGDEAAPTGT FHCVNDGATT WCDFARAIVA GAARRGGRSV AVEGIPTAAY
260 270 280 290
PTPAKRPANS RLSTQSLSDA FGLAPRPWEA ALDDILDRLI GPVRSN
Length:296
Mass (Da):31,012
Last modified:July 28, 2009 - v1
Checksum:iCF87BCDD8647FDA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001510 Genomic DNA Translation: ACS41709.1
RefSeqiWP_015857220.1, NC_012808.1

Genome annotation databases

EnsemblBacteriaiACS41709; ACS41709; MexAM1_META1p4040
KEGGimea:Mex_1p4040

Similar proteinsi

Entry informationi

Entry nameiC5B1A8_METEA
AccessioniPrimary (citable) accession number: C5B1A8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 12, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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