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Protein

Iron-binding protein IscA

Gene

iscA

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35IronUniRule annotation1
Metal bindingi99IronUniRule annotation1
Metal bindingi101IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-binding protein IscAUniRule annotation
Alternative name(s):
Iron-sulfur cluster assembly proteinUniRule annotation
Gene namesi
Name:iscAUniRule annotation
Ordered Locus Names:BWG_2292
OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
Taxonomic identifieri595496 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002152711 – 107Iron-binding protein IscAAdd BLAST107

Proteomic databases

PRIDEiC4ZXA3

Interactioni

Subunit structurei

Homodimer; may form tetramers and higher multimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4ZXA3
SMRiC4ZXA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228314
KOiK13628
OMAiPNETDAC

Family and domain databases

Gene3Di2.60.300.12, 1 hit
HAMAPiMF_01429 Fe_S_insert_IscA, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR016092 FeS_cluster_insertion
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
IPR011302 IscA_proteobacteria
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
TIGRFAMsiTIGR02011 IscA, 1 hit
TIGR00049 TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit

Sequencei

Sequence statusi: Complete.

C4ZXA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITLSDSAA ARVNTFLANR GKGFGLRLGV RTSGCSGMAY VLEFVDEPTP
60 70 80 90 100
EDIVFEDKGV KVVVDGKSLQ FLDGTQLDFV KEGLNEGFKF TNPNVKDECG

CGESFHV
Length:107
Mass (Da):11,556
Last modified:July 28, 2009 - v1
Checksum:iCBA945AD547E77DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA Translation: ACR63084.1
RefSeqiWP_000028953.1, NC_012759.1

Genome annotation databases

EnsemblBacteriaiACR63084; ACR63084; BWG_2292
KEGGiebw:BWG_2292

Similar proteinsi

Entry informationi

Entry nameiISCA_ECOBW
AccessioniPrimary (citable) accession number: C4ZXA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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