UniProtKB - C4ZSW2 (NANT_ECOBW)
Protein
Sialic acid transporter NanT
Gene
nanT
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Functioni
Catalyzes the proton-dependent transport of sialic acid.UniRule annotation
GO - Molecular functioni
- sialic acid:proton symporter activity Source: UniProtKB-UniRule
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sialic acid transporter NanTUniRule annotationAlternative name(s): Sialic acid permeaseUniRule annotation Sialic acid/H(+) symporterUniRule annotation |
Gene namesi | Name:nanTUniRule annotation Ordered Locus Names:BWG_2925 |
Organismi | Escherichia coli (strain K12 / MC4100 / BW2952) |
Taxonomic identifieri | 595496 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 116 – 136 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 148 – 168 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 170 – 190 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 224 – 244 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 247 – 267 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 278 – 298 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 313 – 333 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 353 – 375 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 406 – 426 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 431 – 451 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000214046 | 1 – 496 | Sialic acid transporter NanTAdd BLAST | 496 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_001265_46_8_6 |
OMAi | YPTMLTN |
Family and domain databases
HAMAPi | MF_01238, MFS_NanT, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004742, SA_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00891, 2A0112, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
C4ZSW2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQGEF
60 70 80 90 100
GLTTVQAASL ISAAFISRWF GGLMLGAMGD RYGRRLAMVT SIVLFSAGTL
110 120 130 140 150
ACGFAPGYIT MFIARLVIGM GMAGEYGSSA TYVIESWPKH LRNKASGFLI
160 170 180 190 200
SGFSVGAVVA AQVYSLVVPV WGWRALFFIG ILPIIFALWL RKNIPEAEDW
210 220 230 240 250
KEKHAGKAPV RTMVDILYRG EHRIANIVMT LAAATALWFC FAGNLQNAAI
260 270 280 290 300
VAVLGLLCAA IFISFMVQSA GKRWPTGVML MVVVLFAFLY SWPIQALLPT
310 320 330 340 350
YLKTDLAYNP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA
360 370 380 390 400
SQLLIIPVFA IGGANVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR
410 420 430 440 450
AAGLGFTYNV GALGGALAPI IGALIAQRLD LGTALASLSF SLTFVVILLI
460 470 480 490
GLDMPSRVQR WLRPEALRTH DAIDGKPFSG AVPFGSAKND LVKTKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001396 Genomic DNA Translation: ACR65550.1 |
RefSeqi | WP_000108454.1, NC_012759.1 |
Genome annotation databases
EnsemblBacteriai | ACR65550; ACR65550; BWG_2925 |
KEGGi | ebw:BWG_2925 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001396 Genomic DNA Translation: ACR65550.1 |
RefSeqi | WP_000108454.1, NC_012759.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblBacteriai | ACR65550; ACR65550; BWG_2925 |
KEGGi | ebw:BWG_2925 |
Phylogenomic databases
HOGENOMi | CLU_001265_46_8_6 |
OMAi | YPTMLTN |
Family and domain databases
HAMAPi | MF_01238, MFS_NanT, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004742, SA_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00891, 2A0112, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NANT_ECOBW | |
Accessioni | C4ZSW2Primary (citable) accession number: C4ZSW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |