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UniProtKB - C4ZSG5 (MDTD_ECOBW)
Protein
Putative multidrug resistance protein MdtD
Gene
mdtD
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Putative multidrug resistance protein MdtDUniRule annotation |
Gene namesi | Name:mdtDUniRule annotation Ordered Locus Names:BWG_1867 |
Organismi | Escherichia coli (strain K12 / MC4100 / BW2952) |
Taxonomic identifieri | 595496 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | PeriplasmicUniRule annotationAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 33 – 48 | CytoplasmicUniRule annotationAdd BLAST | 16 | |
Transmembranei | 49 – 69 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 70 – 76 | PeriplasmicUniRule annotation | 7 | |
Transmembranei | 77 – 97 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 98 – 101 | CytoplasmicUniRule annotation | 4 | |
Transmembranei | 102 – 124 | HelicalUniRule annotationAdd BLAST | 23 | |
Topological domaini | 125 – 137 | PeriplasmicUniRule annotationAdd BLAST | 13 | |
Transmembranei | 138 – 158 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 159 – 164 | CytoplasmicUniRule annotation | 6 | |
Transmembranei | 165 – 185 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 186 – 196 | PeriplasmicUniRule annotationAdd BLAST | 11 | |
Transmembranei | 197 – 217 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 218 – 224 | CytoplasmicUniRule annotation | 7 | |
Transmembranei | 225 – 245 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 246 – 262 | PeriplasmicUniRule annotationAdd BLAST | 17 | |
Transmembranei | 263 – 283 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 284 – 285 | CytoplasmicUniRule annotation | 2 | |
Transmembranei | 286 – 306 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 307 – 341 | PeriplasmicUniRule annotationAdd BLAST | 35 | |
Transmembranei | 342 – 362 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 363 – 395 | CytoplasmicUniRule annotationAdd BLAST | 33 | |
Transmembranei | 396 – 416 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 417 – 430 | PeriplasmicUniRule annotationAdd BLAST | 14 | |
Transmembranei | 431 – 451 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 452 – 471 | CytoplasmicUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000215612 | 1 – 471 | Putative multidrug resistance protein MdtDAdd BLAST | 471 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_000960_28_0_6 |
OMAi | FKIHTFS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
HAMAPi | MF_01577, MFS_MdtD, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023721, Multi-R_MdtD |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
C4ZSG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMAQSL GESPLHMHMV
60 70 80 90 100
IVSYVLTVAV MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE
110 120 130 140 150
LLLARALQGV GGAMMVPVGR LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG
160 170 180 190 200
PALGGLLVEY ASWHWIFLIN IPVGIIGAIA TLLLMPNYTM QTRRFDLSGF
210 220 230 240 250
LLLAVGMAVL TLALDGSKGT GLSPLTIAGL VAVGVVALVL YLLHARNNNR
260 270 280 290 300
ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
310 320 330 340 350
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL
360 370 380 390 400
GWYYVLPFVL FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL
410 420 430 440 450
SMSIGVTIAG LLLGLFGSQH VSVDSGTTQT VFMYTWLSMA LIIALPAFIF
460 470
ARVPNDTHQN VAISRRKRSA Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001396 Genomic DNA Translation: ACR63811.1 |
RefSeqi | WP_000130850.1, NC_012759.1 |
Genome annotation databases
KEGGi | ebw:BWG_1867 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001396 Genomic DNA Translation: ACR63811.1 |
RefSeqi | WP_000130850.1, NC_012759.1 |
3D structure databases
SMRi | C4ZSG5 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ebw:BWG_1867 |
Phylogenomic databases
HOGENOMi | CLU_000960_28_0_6 |
OMAi | FKIHTFS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
HAMAPi | MF_01577, MFS_MdtD, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023721, Multi-R_MdtD |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTD_ECOBW | |
Accessioni | C4ZSG5Primary (citable) accession number: C4ZSG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 23, 2022 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |