UniProtKB - C4ZJM0 (RLMM_THASP)
Protein
Ribosomal RNA large subunit methyltransferase M
Gene
rlmM
Organism
Thauera sp. (strain MZ1T)
Status
Functioni
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation
Catalytic activityi
- cytidine2498 in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine2498 in 23S rRNA + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.186UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 198 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 250 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 270 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 286 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Active sitei | 315 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- S-adenosylmethionine-dependent methyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- methylation Source: UniProtKB-KW
- rRNA processing Source: UniProtKB-UniRule
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | rRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)Alternative name(s): 23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation 23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation |
Gene namesi | Name:rlmMUniRule annotation Ordered Locus Names:Tmz1t_1647 |
Organismi | Thauera sp. (strain MZ1T) |
Taxonomic identifieri | 85643 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Zoogloeaceae › Thauera › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000388990 | 1 – 364 | Ribosomal RNA large subunit methyltransferase MAdd BLAST | 364 |
Interactioni
Subunit structurei
Monomer.
UniRule annotationProtein-protein interaction databases
STRINGi | 85643.Tmz1t_1647 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 231 – 234 | S-adenosyl-L-methionine bindingUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | COG2933, Bacteria |
HOGENOMi | CLU_043780_0_0_4 |
OMAi | PVDWMVC |
OrthoDBi | 902245at2 |
Family and domain databases
HAMAPi | MF_01551, 23SrRNA_methyltr_M, 1 hit |
InterProi | View protein in InterPro IPR040739, RlmM_FDX IPR002877, rRNA_MeTrfase_FtsJ_dom IPR011224, rRNA_MeTrfase_M IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF01728, FtsJ, 1 hit PF18125, RlmM_FDX, 1 hit |
PIRSFi | PIRSF028774, UCP028774, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
C4ZJM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQHTPAAAL ACAGLLGYCR AGFEKELAAE LDDIAAEAGL IGYVRAEPDS
60 70 80 90 100
GYVIYETFEP TPLGSFGEST DWRRPVFARQ LLPWFARVDD LPERDRATPI
110 120 130 140 150
VEAVKASGQR FSGVMLETPD TDEAKQRSGF CKRFTEPLAK ALEKAGCLRS
160 170 180 190 200
SRAGLPVLHV LFTSATTAWL AAGQPGQCST WPMGIPRVRM PSNAPSRSTA
210 220 230 240 250
KLSEAFMMLL EEGERDSILR AGQRAVDLGA APGGWTWQLV NRGLRVTAID
260 270 280 290 300
NGPLRDSVMA TEMVEHLKAD GFTWRPHRPV DWMVCDMVEQ PSRIASLMAE
310 320 330 340 350
WVATGRCRYT IFNLKLPMKR RVEAVEQCRE LIRKRLASVG PYDLRIKHLY
360
HDREEVTAFL TLKR
Sequence cautioni
The sequence ACK54402 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001281 Genomic DNA Translation: ACK54402.1 Different initiation. |
RefSeqi | WP_004317117.1, NC_011662.2 |
Genome annotation databases
EnsemblBacteriai | ACK54402; ACK54402; Tmz1t_1647 |
KEGGi | tmz:Tmz1t_1647 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001281 Genomic DNA Translation: ACK54402.1 Different initiation. |
RefSeqi | WP_004317117.1, NC_011662.2 |
3D structure databases
SMRi | C4ZJM0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 85643.Tmz1t_1647 |
Genome annotation databases
EnsemblBacteriai | ACK54402; ACK54402; Tmz1t_1647 |
KEGGi | tmz:Tmz1t_1647 |
Phylogenomic databases
eggNOGi | COG2933, Bacteria |
HOGENOMi | CLU_043780_0_0_4 |
OMAi | PVDWMVC |
OrthoDBi | 902245at2 |
Family and domain databases
HAMAPi | MF_01551, 23SrRNA_methyltr_M, 1 hit |
InterProi | View protein in InterPro IPR040739, RlmM_FDX IPR002877, rRNA_MeTrfase_FtsJ_dom IPR011224, rRNA_MeTrfase_M IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF01728, FtsJ, 1 hit PF18125, RlmM_FDX, 1 hit |
PIRSFi | PIRSF028774, UCP028774, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RLMM_THASP | |
Accessioni | C4ZJM0Primary (citable) accession number: C4ZJM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 24, 2009 |
Last sequence update: | November 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families