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Protein

Ras-related protein SEC4

Gene

SEC4

Organism
Candida albicans (strain WO-1) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein SEC4
Gene namesi
Name:SEC4
ORF Names:CAWG_01525
OrganismiCandida albicans (strain WO-1) (Yeast)
Taxonomic identifieri294748 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000001429 Componenti: Chromosome R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004130571 – 210Ras-related protein SEC4Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi209S-geranylgeranyl cysteineBy similarity1
Lipidationi210S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PRIDEiC4YL11

Structurei

3D structure databases

ProteinModelPortaliC4YL11
SMRiC4YL11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968
OMAiNKCDWED
OrthoDBiEOG092C5MDH

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

C4YL11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGKGTSSRA YDMIMKLLLV GDSGVGKSCL LLRFVEDKFN PSFITTIGID
60 70 80 90 100
FKIRTIESKG KRIKLQVWDT AGQERFRTIT TAYYRGAMGI VLIYDVTDSR
110 120 130 140 150
SFENVENWFQ TVTQHANEDA QIFLVGNKCD DEVNRQVSKE QGQELAAKLN
160 170 180 190 200
VPFLEASAKS NENVDSIFYE LASIIQEKHV EENIGGVGGA SGAGGIDVSQ
210
NNSGAKNNCC
Length:210
Mass (Da):23,077
Last modified:July 28, 2009 - v1
Checksum:i4E1890D887DC6131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017183 Genomic DNA Translation: AAC50022.1
AF015306 Genomic DNA Translation: AAB67974.1
CM000309 Genomic DNA Translation: EEQ43292.1

Genome annotation databases

EnsemblFungiiEEQ43292; EEQ43292; CAWG_01525

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017183 Genomic DNA Translation: AAC50022.1
AF015306 Genomic DNA Translation: AAB67974.1
CM000309 Genomic DNA Translation: EEQ43292.1

3D structure databases

ProteinModelPortaliC4YL11
SMRiC4YL11
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC4YL11

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ43292; EEQ43292; CAWG_01525

Phylogenomic databases

HOGENOMiHOG000233968
OMAiNKCDWED
OrthoDBiEOG092C5MDH

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC4_CANAW
AccessioniPrimary (citable) accession number: C4YL11
Secondary accession number(s): O14462, Q5A994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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