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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

ACYPI005028

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91S-adenosyl-L-methionineUniRule annotation1
Binding sitei115S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
Biological processUbiquinone biosynthesisUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:ACYPI005028Imported
Synonyms:coq5UniRule annotation, LOC100163980Imported
OrganismiAcyrthosiphon pisum (Pea aphid)
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
Proteomesi
  • UP000007819 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex.UniRule annotation

Protein-protein interaction databases

STRINGi7029.ACYPI005028-PA

Structurei

3D structure databases

ProteinModelPortaliC4WS56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 145S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1540 Eukaryota
COG2226 LUCA
HOGENOMiHOG000249463
KOiK06127
OMAiVRNFENL

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit

Sequencei

Sequence statusi: Complete.

C4WS56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIFNRFNK SVAHYYKFAA LYSTQTHFGF QTVDEAEKSK KVHQVFKSVA
60 70 80 90 100
DSYDAMNDVM SCGVHRLWKD ELMRTLDPSP RTRLLDVAGG TGDIAFRYLN
110 120 130 140 150
YISDMKGDGH VTIADINGSM LEEGKKRALN LKLNQDNVSW VECDAENLPM
160 170 180 190 200
ESDSYSAYTI AFGIRNVTHI DKALDEAYRV LEPGGRFLCL EFSQVNPAAL
210 220 230 240 250
RWLYDQYSFN VIPVMGHVVA GQWKPYQYLV ESIRKFPCQE DFKYMIESAG
260 270
FRCVTYTNLT FGVVAIHSGF KL
Length:272
Mass (Da):31,020
Last modified:July 28, 2009 - v1
Checksum:iE8FA775D2F927BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02021936 Genomic DNA No translation available.
AK340053 mRNA Translation: BAH70726.1
RefSeqiNP_001155605.1, NM_001162133.2
UniGeneiAps.3483
Aps.75030

Genome annotation databases

EnsemblMetazoaiACYPI005028-RA; ACYPI005028-PA; ACYPI005028
GeneIDi100163980
KEGGiapi:100163980

Similar proteinsi

Entry informationi

Entry nameiC4WS56_ACYPI
AccessioniPrimary (citable) accession number: C4WS56
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 18, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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