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Protein

S-adenosylmethionine synthase

Gene

PAS_chr3_0876

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • K+UniRule annotationNote: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.UniRule annotation
  • Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (PAS_chr3_0876)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PotassiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr3_0876Imported
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002493112.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 104S-AdoMet_synt_NInterPro annotationAdd BLAST98
Domaini119 – 239S-AdoMet_synt_MInterPro annotationAdd BLAST121
Domaini241 – 378S-AdoMet_synt_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the AdoMet synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1506 Eukaryota
COG0192 LUCA
HOGENOMiHOG000245710
InParanoidiC4R5U7
KOiK00789
OMAiPGHFLFT
OrthoDBiEOG092C2SCC

Family and domain databases

HAMAPiMF_00086 S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam
PANTHERiPTHR11964 PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773 S-AdoMet_synt_C, 1 hit
PF02772 S-AdoMet_synt_M, 1 hit
PF00438 S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497 MAT, 1 hit
SUPFAMiSSF55973 SSF55973, 3 hits
TIGRFAMsiTIGR01034 metK, 1 hit
PROSITEiView protein in PROSITE
PS00376 ADOMET_SYNTHASE_1, 1 hit
PS00377 ADOMET_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

C4R5U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNETFFFT SESVGEGHPD KLCDQVSDAV LDACLTVDPL SKVACETAAK
60 70 80 90 100
TGMVMVFGEI TTKAQLDFQK IIRDTVKHIG YDHSDKGLDY KTMSVLVAIE
110 120 130 140 150
HQSPDIAQGL HYEKALEELG AGDQGIMFGY ATDETDEKLP LTLLLAHQLN
160 170 180 190 200
HELASCRRSG SLPWLRPDTK TQVTIEYKYD NGAVIPLRVD TVVISAQHSE
210 220 230 240 250
EITTADIRVQ LTEHVIKKVI PSHLLDEKTK YHIQPSGKFI IGGIAGDAGL
260 270 280 290 300
TGRKIIVDTY GGWGAHGGGA FSGKDFSKVD RSAAYAARWV AKSLVHAKLA
310 320 330 340 350
RRCLVQFSYA IGVPEPLSIY VDTYGTSTYS SDELVKIINK NFDLRPGVIV
360 370 380
KELDLARPIY FKTASYGHFT NQENPWEQPK VLKL
Length:384
Mass (Da):42,375
Last modified:July 7, 2009 - v1
Checksum:i75345BAB5F23306C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA Translation: CAY70933.1
RefSeqiXP_002493112.1, XM_002493067.1

Genome annotation databases

EnsemblFungiiCAY70933; CAY70933; PAS_chr3_0876
GeneIDi8200232
KEGGippa:PAS_chr3_0876

Similar proteinsi

Entry informationi

Entry nameiC4R5U7_KOMPG
AccessioniPrimary (citable) accession number: C4R5U7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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