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Protein

5'-3' exoribonuclease 1

Gene

PAS_chr3_0432

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr3_0432Imported
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002492661.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 226XRN_NInterPro annotationAdd BLAST226

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
COG5049 LUCA
HOGENOMiHOG000160331
InParanoidiC4R4J6
KOiK12618
OMAiWVLMGFM
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

Sequencei

Sequence statusi: Complete.

C4R4J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIPKFFRYI SERWPMISEP IEDSQIAEFD NLYLDMNSIL HNCTHSNDGS
60 70 80 90 100
VDLMKEEEMF SAIFAYIEHL FTLIKPGKTF FMAIDGVAPR AKMNQQRSRR
110 120 130 140 150
FRTAIEAEKS VEIAQKNGLI TSKDENFDSN CITPGTEFMA KVTTNLKFFI
160 170 180 190 200
HQKISSDAKW QKVQVILSGH EVPGEGEHKI MDYIRFLKAQ EGYDPNTRHC
210 220 230 240 250
IYGLDADLIM LGLVIHDPHF AILREEVVFG RGSKASSTDV SEQQFYLLHL
260 270 280 290 300
SLLREYLALE FKDLEDQIKF DYDLERILDD FIFIMYVIGN DFLPNLPDLH
310 320 330 340 350
INKGAFPRLL ATIKETMIDS DGYLQEGGVI NMERFGLWLD HLSQFELQNF
360 370 380 390 400
EQVDVDVEWF NKQLENISLD GERKRERAGR KLLLRRQQEL ISKLRPWILE
410 420 430 440 450
FYSSRDNIYS AHDDDSLIPT LQLDTELMEE EIKLPFIKQF ALDVGFFIVH
460 470 480 490 500
SKSQNTYHAK IDIDGINVNE SDEEFEARVL YIRKKIKEYE NSIFVEDENT
510 520 530 540 550
LEEQKNIYDT KFVNWKNKYY KEKFGFTLSD TEDILKLTES YIQGLQWVLF
560 570 580 590 600
YYYRGVPSWQ WYYPYYYAPR ISDIKLGIKA CLEFDKGTPF KPFEQLMAVL
610 620 630 640 650
PARSKQLVPA CYRPLMTDPN SPIIEFYPDE VEIDKNGKTA SWEAVVKINF
660 670 680 690 700
VDEKRLLEAL EPYNSKLNAE ERQRNSLGTN IEFSYHPQVN QVHSSPIPTI
710 720 730 740 750
FPDITEDHCY EIVVEFDKLH SSTYAKPMKG AKQGINLLAG FPTLKTIPFT
760 770 780 790 800
SQLMLAECHI FNQPTKSESM ILSTQNPFEG LTVEQFAAQN LGQTIYVNWP
810 820 830 840 850
YLKEAKVVAV SDGLNVFEPG NKSIRTTRME SSEVSEFASD VRYISETLFK
860 870 880 890 900
RKGVLLVNYT EEELQGTPEP RRSPHNDDAI QGIVFVKKVN GVIRTRSGAY
910 920 930 940 950
VKTYSDKIEK YPINLLVDDV VNKDRRLLEK PPVPLEEEFP KGTTLISLGA
960 970 980 990 1000
FAYGTPATVV DHQNDLMTVR FVNQPIKHEF NYGEIQAQRE AHTNVYYPSF
1010 1020 1030 1040 1050
KVAKIVGITA LALSRITSSY RIVNGAKKTV NIGLDLKFEG RKLKVLGYTK
1060 1070 1080 1090 1100
RNEKHWSYSA LAVNLLQQYQ KRFPSVFKII SLRNDSSIPE AKELFPQVPA
1110 1120 1130 1140 1150
SQVDEKVNEL VAWVKEQKKS FVVATLESES LTKVSIGKIE QEVIKFVSKP
1160 1170 1180 1190 1200
HEHIPQKGLK GVPREATLDI SNSSQFLSKQ TFNLGDRVIY VEDSGKVPNF
1210 1220 1230 1240 1250
SKGTVIGVRS VGTKVTLNVL FDLPLLSGNT FDGRLATPRG VTVDSSLVLN
1260 1270 1280 1290 1300
LTKRQLIYHD RKPAKKEGKP GVKKTSQDSK KQTVKLQNGS GKAKQAQDAE
1310 1320 1330 1340 1350
LSVTTTPVPV PAANTAPVTA SVQATSVVTA TVPTSKPSNN SEDEHELLRL
1360 1370 1380 1390 1400
LKGNKDSSES QGSQEPLART SIQQIYGTVF NQVLSAQPQL QPVRGFSNPV
1410 1420 1430 1440 1450
PETPVNGVQA NEQHSDSTPQ NHSRDENQGR GRGRGRGNRR GRGRGRGKGG

Q
Length:1,451
Mass (Da):165,037
Last modified:July 7, 2009 - v1
Checksum:i56A40E5A7FFAFD04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA Translation: CAY70482.1
RefSeqiXP_002492661.1, XM_002492616.1

Genome annotation databases

EnsemblFungiiCAY70482; CAY70482; PAS_chr3_0432
GeneIDi8199563
KEGGippa:PAS_chr3_0432

Similar proteinsi

Entry informationi

Entry nameiC4R4J6_KOMPG
AccessioniPrimary (citable) accession number: C4R4J6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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