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Protein

5'-3' exoribonuclease 1

Gene

PAS_chr3_0432

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PAS_chr3_0432Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri644223 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000314 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
644223.XP_002492661.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 226XRN_NInterPro annotationAdd BLAST226

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2044 Eukaryota
COG5049 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000160331

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C4R4J6

KEGG Orthology (KO)

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KOi
K12618

Identification of Orthologs from Complete Genome Data

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OMAi
YPAISQL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2

The PANTHER Classification System

More...
PANTHERi
PTHR12341 PTHR12341, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03159 XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006743 Exonuclease_Xnr1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4R4J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIPKFFRYI SERWPMISEP IEDSQIAEFD NLYLDMNSIL HNCTHSNDGS
60 70 80 90 100
VDLMKEEEMF SAIFAYIEHL FTLIKPGKTF FMAIDGVAPR AKMNQQRSRR
110 120 130 140 150
FRTAIEAEKS VEIAQKNGLI TSKDENFDSN CITPGTEFMA KVTTNLKFFI
160 170 180 190 200
HQKISSDAKW QKVQVILSGH EVPGEGEHKI MDYIRFLKAQ EGYDPNTRHC
210 220 230 240 250
IYGLDADLIM LGLVIHDPHF AILREEVVFG RGSKASSTDV SEQQFYLLHL
260 270 280 290 300
SLLREYLALE FKDLEDQIKF DYDLERILDD FIFIMYVIGN DFLPNLPDLH
310 320 330 340 350
INKGAFPRLL ATIKETMIDS DGYLQEGGVI NMERFGLWLD HLSQFELQNF
360 370 380 390 400
EQVDVDVEWF NKQLENISLD GERKRERAGR KLLLRRQQEL ISKLRPWILE
410 420 430 440 450
FYSSRDNIYS AHDDDSLIPT LQLDTELMEE EIKLPFIKQF ALDVGFFIVH
460 470 480 490 500
SKSQNTYHAK IDIDGINVNE SDEEFEARVL YIRKKIKEYE NSIFVEDENT
510 520 530 540 550
LEEQKNIYDT KFVNWKNKYY KEKFGFTLSD TEDILKLTES YIQGLQWVLF
560 570 580 590 600
YYYRGVPSWQ WYYPYYYAPR ISDIKLGIKA CLEFDKGTPF KPFEQLMAVL
610 620 630 640 650
PARSKQLVPA CYRPLMTDPN SPIIEFYPDE VEIDKNGKTA SWEAVVKINF
660 670 680 690 700
VDEKRLLEAL EPYNSKLNAE ERQRNSLGTN IEFSYHPQVN QVHSSPIPTI
710 720 730 740 750
FPDITEDHCY EIVVEFDKLH SSTYAKPMKG AKQGINLLAG FPTLKTIPFT
760 770 780 790 800
SQLMLAECHI FNQPTKSESM ILSTQNPFEG LTVEQFAAQN LGQTIYVNWP
810 820 830 840 850
YLKEAKVVAV SDGLNVFEPG NKSIRTTRME SSEVSEFASD VRYISETLFK
860 870 880 890 900
RKGVLLVNYT EEELQGTPEP RRSPHNDDAI QGIVFVKKVN GVIRTRSGAY
910 920 930 940 950
VKTYSDKIEK YPINLLVDDV VNKDRRLLEK PPVPLEEEFP KGTTLISLGA
960 970 980 990 1000
FAYGTPATVV DHQNDLMTVR FVNQPIKHEF NYGEIQAQRE AHTNVYYPSF
1010 1020 1030 1040 1050
KVAKIVGITA LALSRITSSY RIVNGAKKTV NIGLDLKFEG RKLKVLGYTK
1060 1070 1080 1090 1100
RNEKHWSYSA LAVNLLQQYQ KRFPSVFKII SLRNDSSIPE AKELFPQVPA
1110 1120 1130 1140 1150
SQVDEKVNEL VAWVKEQKKS FVVATLESES LTKVSIGKIE QEVIKFVSKP
1160 1170 1180 1190 1200
HEHIPQKGLK GVPREATLDI SNSSQFLSKQ TFNLGDRVIY VEDSGKVPNF
1210 1220 1230 1240 1250
SKGTVIGVRS VGTKVTLNVL FDLPLLSGNT FDGRLATPRG VTVDSSLVLN
1260 1270 1280 1290 1300
LTKRQLIYHD RKPAKKEGKP GVKKTSQDSK KQTVKLQNGS GKAKQAQDAE
1310 1320 1330 1340 1350
LSVTTTPVPV PAANTAPVTA SVQATSVVTA TVPTSKPSNN SEDEHELLRL
1360 1370 1380 1390 1400
LKGNKDSSES QGSQEPLART SIQQIYGTVF NQVLSAQPQL QPVRGFSNPV
1410 1420 1430 1440 1450
PETPVNGVQA NEQHSDSTPQ NHSRDENQGR GRGRGRGNRR GRGRGRGKGG

Q
Length:1,451
Mass (Da):165,037
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56A40E5A7FFAFD04
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN392321 Genomic DNA Translation: CAY70482.1

NCBI Reference Sequences

More...
RefSeqi
XP_002492661.1, XM_002492616.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAY70482; CAY70482; PAS_chr3_0432

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8199563

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ppa:PAS_chr3_0432

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA Translation: CAY70482.1
RefSeqiXP_002492661.1, XM_002492616.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi644223.XP_002492661.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAY70482; CAY70482; PAS_chr3_0432
GeneIDi8199563
KEGGippa:PAS_chr3_0432

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
COG5049 LUCA
HOGENOMiHOG000160331
InParanoidiC4R4J6
KOiK12618
OMAiYPAISQL

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC4R4J6_KOMPG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4R4J6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: January 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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