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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177PROSITE-ProRule annotation1
Active sitei383PROSITE-ProRule annotation1
Active sitei441PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERipicpa-KEX1 Carboxypeptidase_S10

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:PAS_chr2-1_0174
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 512LumenalSequence analysisAdd BLAST496
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 623CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000041194017 – 623Pheromone-processing carboxypeptidase KEX1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002491061.1

Structurei

3D structure databases

ProteinModelPortaliC4QZV7
SMRiC4QZV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiC4QZV7
KOiK01288
OMAiNEIYFAG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4QZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLCLLLP LVAVSASPID LGSQKDYLVL DLPGLSHLSE TQRPTMHAGL
60 70 80 90 100
LPLNLSFVAD DDTEYFFWRF SKQDVDRADI VFWLNGGPGC SSMDGALMEL
110 120 130 140 150
GPFVINPKQE VEYNEGTWVE AADVVFVDQP GGTGFSSTTN YLTELTEVAD
160 170 180 190 200
GFVTFLARYF HLFPADVYKK FTLGGESYAG QYVPYILKAI MDDLKSDSGQ
210 220 230 240 250
LPKELYLKGA LIGNGWIDPN EQSLSYLEFF IKKELIDIHG SYMPGLLQQQ
260 270 280 290 300
EKCQNLINHS SGEASESQIS YSACEKILND ALRFTRDKKA PLDQQCINMY
310 320 330 340 350
DYTLRDTYPS CGMSWPPYLP DVTAFLQKKS VLEALHLDSS ASWSECSARV
360 370 380 390 400
GSHLKNKISV PSVDILPDLL QEIPIILFNG DHDIICNCIG TERMIDKLEF
410 420 430 440 450
NGDQGFTEGT EYIPWFYNEV NVGKVISERN LTYVRVYNSS HMVPFDNTPV
460 470 480 490 500
SRGLLDIYFD NFEDVEYNNV SGIATPVYDV DKNITYIDSN DPRLQNGPKS
510 520 530 540 550
SSTDDSAAHG NPFFYYVFEL FVIVLLLCGL VYLYQYYSNS APHSILADKH
560 570 580 590 600
KKKSKNKSKN VRFLDDLESN LDLDNTDDKK DNSVMSKLLS SMGYQAQEPY
610 620
KPLDKGANAD LDIEMDSHGT SEK
Length:623
Mass (Da):70,018
Last modified:July 7, 2009 - v1
Checksum:iCC7B0683829D8FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA Translation: CAY68781.1
RefSeqiXP_002491061.1, XM_002491016.1

Genome annotation databases

EnsemblFungiiCAY68781; CAY68781; PAS_chr2-1_0174
GeneIDi8198557
KEGGippa:PAS_chr2-1_0174

Similar proteinsi

Entry informationi

Entry nameiKEX1_KOMPG
AccessioniPrimary (citable) accession number: C4QZV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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