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Entry version 49 (11 Dec 2019)
Sequence version 1 (07 Jul 2009)
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Protein

Phosphatidylethanolamine N-methyltransferase

Gene

CHO2

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in the pathway phosphatidylcholine biosynthesis, which is part of Phospholipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylethanolamine N-methyltransferaseUniRule annotation (EC:2.1.1.17UniRule annotation)
Short name:
PE methyltransferaseUniRule annotation
Short name:
PEAMTUniRule annotation
Short name:
PEMTUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHO2
Ordered Locus Names:PAS_chr1-4_0093
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri644223 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000314 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51LumenalUniRule annotationAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Topological domaini73 – 75CytoplasmicUniRule annotation3
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Topological domaini97 – 150LumenalUniRule annotationAdd BLAST54
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Topological domaini172 – 179CytoplasmicUniRule annotation8
Transmembranei180 – 200HelicalUniRule annotationAdd BLAST21
Topological domaini201 – 227LumenalUniRule annotationAdd BLAST27
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Topological domaini249 – 258CytoplasmicUniRule annotation10
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21
Topological domaini280 – 330LumenalUniRule annotationAdd BLAST51
Transmembranei331 – 351HelicalUniRule annotationAdd BLAST21
Topological domaini352 – 354CytoplasmicUniRule annotation3
Transmembranei355 – 375HelicalUniRule annotationAdd BLAST21
Topological domaini376 – 446LumenalUniRule annotationAdd BLAST71
Transmembranei447 – 467HelicalUniRule annotationAdd BLAST21
Topological domaini468CytoplasmicUniRule annotation1
Transmembranei469 – 489HelicalUniRule annotationAdd BLAST21
Topological domaini490 – 531LumenalUniRule annotationAdd BLAST42
Transmembranei532 – 552HelicalUniRule annotationAdd BLAST21
Topological domaini553 – 890CytoplasmicUniRule annotationAdd BLAST338

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004059081 – 890Phosphatidylethanolamine N-methyltransferaseAdd BLAST890

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C4QXE9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4922.CAY67922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C4QXE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE80 Eukaryota
ENOG410XPQM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247858

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C4QXE9

KEGG Orthology (KO)

More...
KOi
K16369

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAWRQWK

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03217 PEMT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007318 Phopholipid_MeTrfase
IPR016219 Phosphatid-EA_MeTrfase_fun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04191 PEMT, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000383 PEAMT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51598 SAM_CHO2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4QXE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKESKFSYN SKDEKKYSLG KTFRGDIFNV PETHDMVRSL FDPTVKKSVS
60 70 80 90 100
DYLIVLSLFI NGIVYYYSPV TWRIPVFIVL YSFWRLGYNL GIGILLYKQS
110 120 130 140 150
KSHSMFHWLK QIQINGGWAK KFVELELSSK LNAQQLNSVP DEFKTWIVFR
160 170 180 190 200
SLVNLILMND FTTYMCLVFA CSDGAFNQSL SLIFLRWVLG ISFFIFNIIV
210 220 230 240 250
KLNAHLIVKD YAWYWGDFFF RLHNNEELIF DGVFDLAPHP MYSIGYAGYY
260 270 280 290 300
GCALMTKSYT VLIMSIFGHL LQFLFLNYVE TPHIEKIYGD DNLSENTISV
310 320 330 340 350
NKRDDSVFIG TGGKPLVMLT KNFNWLRTND IFTVVLALYA SIVPIFLPAS
360 370 380 390 400
YNNSIIILAI VVKIGTSFVL NSVLYLQSRF KSWTLSFIKN YGTINISILD
410 420 430 440 450
NKELLERLSF QNWTLLQNNT LVLNYSMLFT ISVREVMYNE KFWQTEWLPL
460 470 480 490 500
RFILAALMIL GQFLTVHQMI DSIGLFGWYY GDFFIGVLSS HKSEVTTLSR
510 520 530 540 550
SGIYHFLNNP ERVTSNLTVW ALYLLFNNSN KIFLVIALLF TMNNLIVLNF
560 570 580 590 600
IEKPHMVKLY GEQNVLKHTS GIEKSINSLF LPNHVQGTIV KLSGSIDKVI
610 620 630 640 650
QDSSKVIDEF IRNKHNQKPK ELSLKKRRNS FQQVIELIRG STDDTLTINL
660 670 680 690 700
QELNDQGQLQ LLNLLRKDDT DFYNLGDPIK VEWNMEDHKG KDKAWIGLYN
710 720 730 740 750
IFQTSETRTK TLVSSKGYWI PIHREKYINL SDKIRNEEDC ILEDELNRGV
760 770 780 790 800
VQFSAELLPW VPGTYELRLH ANEKHEVLAI SKPFDIVVKK IDVPTSDDIG
810 820 830 840 850
DERLEDFANK LYQGFVSKLF PAVESIEDES NWFLQMHIKE NARQVEKLCS
860 870 880 890
TLSQSCGVHL TKKAIVDEKC LKDLSFKISK LRKMLDELML
Length:890
Mass (Da):103,146
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1B7105FD619594
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN392319 Genomic DNA Translation: CAY67922.1

NCBI Reference Sequences

More...
RefSeqi
XP_002490203.1, XM_002490158.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAY67922; CAY67922; PAS_chr1-4_0093

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8197310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ppa:PAS_chr1-4_0093

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392319 Genomic DNA Translation: CAY67922.1
RefSeqiXP_002490203.1, XM_002490158.1

3D structure databases

SMRiC4QXE9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4922.CAY67922

Proteomic databases

PRIDEiC4QXE9

Genome annotation databases

EnsemblFungiiCAY67922; CAY67922; PAS_chr1-4_0093
GeneIDi8197310
KEGGippa:PAS_chr1-4_0093

Phylogenomic databases

eggNOGiENOG410IE80 Eukaryota
ENOG410XPQM LUCA
HOGENOMiHOG000247858
InParanoidiC4QXE9
KOiK16369
OMAiEAWRQWK

Enzyme and pathway databases

UniPathwayiUPA00753

Family and domain databases

HAMAPiMF_03217 PEMT, 1 hit
InterProiView protein in InterPro
IPR007318 Phopholipid_MeTrfase
IPR016219 Phosphatid-EA_MeTrfase_fun
PfamiView protein in Pfam
PF04191 PEMT, 2 hits
PIRSFiPIRSF000383 PEAMT, 1 hit
PROSITEiView protein in PROSITE
PS51598 SAM_CHO2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHO2_KOMPG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4QXE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 7, 2009
Last modified: December 11, 2019
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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