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Entry version 66 (26 Feb 2020)
Sequence version 1 (07 Jul 2009)
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Protein
Submitted name:

TLR2B

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TLR2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei537 – 558HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501011009123 – 732Sequence analysisAdd BLAST710

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini587 – 732TIRInterPro annotationAdd BLAST146

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027185 TLR2
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24365:SF17 PTHR24365:SF17, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 7 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 11 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4PC13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHTWKMWAIC TALAAYLPEE QALRQACLSC DATQSCNCSF MGLDFIPPGL
60 70 80 90 100
TGKITVLNLA HNRIKVIRTH DLQKAVNLRT LLLQSNQISS IDEDSFGSQG
110 120 130 140 150
KLELLDLSNN SLAHLSPVWF GPLFSLQHLR IQGNSYSDLG ESSPFSSLRN
160 170 180 190 200
LSSLHLGNPQ FSIIRQGNFE GIVFLNTLRI DGDNLSQYEP GSLKSIRKIN
210 220 230 240 250
HMIISIRRID VFSAVIRDLL HSAIWLDVRK LAFSVPEKIQ LLRIMSSSFA
260 270 280 290 300
KKISLKQCLF TDATVPEIVS ILEGMPKLME VEMKDCTLLG TGKWYKQIHA
310 320 330 340 350
NQSQSLRILT IENLSIEEFY LFTDLQSVLD LLSLFRKVTV ENTKVFLVPC
360 370 380 390 400
KLSQHLLSLE YLDLSANLLG DQSLEHSACQ GAWPSLQTLN LSQNSLSDLK
410 420 430 440 450
MTGKSLFHLR NLNLLDISEN NFGEIPDMCE WPENLKYLNL SSTQIPKLTT
460 470 480 490 500
CIPSTLEVLD VSANNLQDFG LQLPFLKELY LTKNHLKTLP EATDIPNLVA
510 520 530 540 550
MSISRNKLNS FSKEELTVRG AQVGSVQLSL MECHRSLXVS LICTLVFLFI
560 570 580 590 600
LILVVVGYKY HAVWYMRMTW AWLQAKRKPK RAPTKDICYD AFVSYSENDS
610 620 630 640 650
NWVENIMVQQ LEQACPPFRL CLHKRDFVPG KWIVDNIIDS IEKSHKTLFV
660 670 680 690 700
LSEHFVQSEW CKYELDFSHF RLFDENNDVA ILILLEPIQS QAIPKRFCKL
710 720 730
RKIMNTKTYL EWPPDEEQQQ MFWENLKAAL KS
Length:732
Mass (Da):83,612
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAF6A4EAD83FF5DD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ915347 Genomic DNA Translation: ACR26376.1
FJ915348 Genomic DNA Translation: ACR26377.1
FJ915349 Genomic DNA Translation: ACR26378.1
FJ915350 Genomic DNA Translation: ACR26379.1
FJ915351 Genomic DNA Translation: ACR26380.1
FJ915352 Genomic DNA Translation: ACR26381.1
FJ915353 Genomic DNA Translation: ACR26382.1
FJ915354 Genomic DNA Translation: ACR26383.1
FJ915355 Genomic DNA Translation: ACR26384.1
FJ915356 Genomic DNA Translation: ACR26385.1
FJ915357 Genomic DNA Translation: ACR26386.1
FJ915358 Genomic DNA Translation: ACR26387.1
FJ915359 Genomic DNA Translation: ACR26388.1
FJ915360 Genomic DNA Translation: ACR26389.1
FJ915361 Genomic DNA Translation: ACR26390.1
FJ915362 Genomic DNA Translation: ACR26391.1
FJ915363 Genomic DNA Translation: ACR26392.1
FJ915373 Genomic DNA Translation: ACR26402.1
FJ915374 Genomic DNA Translation: ACR26403.1
FJ915379 Genomic DNA Translation: ACR26408.1
FJ915380 Genomic DNA Translation: ACR26409.1
FJ915381 Genomic DNA Translation: ACR26410.1
FJ915382 Genomic DNA Translation: ACR26411.1
FJ915383 Genomic DNA Translation: ACR26412.1
FJ915384 Genomic DNA Translation: ACR26413.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ915347 Genomic DNA Translation: ACR26376.1
FJ915348 Genomic DNA Translation: ACR26377.1
FJ915349 Genomic DNA Translation: ACR26378.1
FJ915350 Genomic DNA Translation: ACR26379.1
FJ915351 Genomic DNA Translation: ACR26380.1
FJ915352 Genomic DNA Translation: ACR26381.1
FJ915353 Genomic DNA Translation: ACR26382.1
FJ915354 Genomic DNA Translation: ACR26383.1
FJ915355 Genomic DNA Translation: ACR26384.1
FJ915356 Genomic DNA Translation: ACR26385.1
FJ915357 Genomic DNA Translation: ACR26386.1
FJ915358 Genomic DNA Translation: ACR26387.1
FJ915359 Genomic DNA Translation: ACR26388.1
FJ915360 Genomic DNA Translation: ACR26389.1
FJ915361 Genomic DNA Translation: ACR26390.1
FJ915362 Genomic DNA Translation: ACR26391.1
FJ915363 Genomic DNA Translation: ACR26392.1
FJ915373 Genomic DNA Translation: ACR26402.1
FJ915374 Genomic DNA Translation: ACR26403.1
FJ915379 Genomic DNA Translation: ACR26408.1
FJ915380 Genomic DNA Translation: ACR26409.1
FJ915381 Genomic DNA Translation: ACR26410.1
FJ915382 Genomic DNA Translation: ACR26411.1
FJ915383 Genomic DNA Translation: ACR26412.1
FJ915384 Genomic DNA Translation: ACR26413.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027185 TLR2
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF17 PTHR24365:SF17, 2 hits
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC4PC13_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4PC13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: February 26, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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