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Entry version 57 (05 Jun 2019)
Sequence version 1 (07 Jul 2009)
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Protein
Submitted name:

Uncharacterized protein

Gene

CL6EHI_170180

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CL6EHI_170180Imported, EHI_170180Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolyticaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001926 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
AmoebaDB:EHI_170180

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini482 – 640DHR-1InterPro annotationAdd BLAST159
Domaini1869 – 2318DHR-2InterPro annotationAdd BLAST450

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1519 – 1539Sequence analysisAdd BLAST21
Coiled coili1833 – 1853Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C4M1E0

Identification of Orthologs from Complete Genome Data

More...
OMAi
NINDSHH

Database of Orthologous Groups

More...
OrthoDBi
19224at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4M1E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSPGLSDI RYKRRTVADA KKTAQLRKIF DCYDTECVSE LNTEQLRRYF
60 70 80 90 100
AKEKGLYLSQ EDIKKILSEI LQYNFRLPFT DFAQLNDYIE TNKNSLKEKS
110 120 130 140 150
NERNQCSVLF ESQLLEDKDR IPYFSNILSP KDITFVTKKR PEQSHLKYIE
160 170 180 190 200
GISSIENDSI VKMFIDILFA DLTNVIMKKV IFEPPKPFES RYVNFDGDET
210 220 230 240 250
IANEVSISLL NNDNCIEDRR TLREPLFDMV RTQTKLNITP IKPITYNVVS
260 270 280 290 300
YYLCQITDIQ FGVCTSAKGF IEPLYGYFAV YDYNEHEKKF IKITESFRVD
310 320 330 340 350
INNSDVRVSG QWITAKDTQR DVNKFILPLE VNKYSNHELK GVLTIYKNAE
360 370 380 390 400
ADLFQRELYF TEKKNIKPRE VKKFIMDNMY LQYVCVGFAD FKFSNDGKLS
410 420 430 440 450
VAPRLGFCQL KMEKEEDIAT LFSPSVKSKQ INGEWKMKIT QISLEEMENI
460 470 480 490 500
VDWNDHGISE NEVTENSTRI LQPLEMRENH FSHNLFIYPL KVTSSSFSLK
510 520 530 540 550
KKFNSAVVKI YLQDTQTIPE SKSLEVFYPI LPGRPFDKSF TTAAPYSKNN
560 570 580 590 600
IYFDEAKLKL PLNINDSHHL LFIVDDVFEE DPNTKETRFG FLPLFEHGHL
610 620 630 640 650
IQNDVYKIEL FKGPIMESYL NAKKLPDTKK MILHVRLNFL TQFMVQDETV
660 670 680 690 700
YKLIRSVDTN SFKSIDNVLE LFSQLKKNQP YKNQLIHSFP LLMKLMLQLF
710 720 730 740 750
NNEISNVESG KNLVLSMLHL MDAVEDDSLK ESFVTEQFKE DFTQPQKEMI
760 770 780 790 800
FDSLTRSLVA ALSVNGIHVS IAKHLNFFLK IIIKSLLFWM QKEDLFEKEN
810 820 830 840 850
RFQLIAIQYS QISTQFKTEL INLFEQLAIF IRKSVQSKRY SYLNYVNYII
860 870 880 890 900
GQFLKDLLRF YSRTTTMEAL ESYINTLSCF YENKSTTLFN PKNSKYGNES
910 920 930 940 950
DESWKIIQLL KIDFIRDLHQ FVYFYEINVP TISPMTSCAK FIENIFNKHY
960 970 980 990 1000
FVEFTVQHLT DSMARDDSVC KYALMVLAEQ IIKMDTYRGW TEEERSCIAE
1010 1020 1030 1040 1050
MYFSYVNYVC IEYKRMVSRW HRAQTVTTTH AQVDDVSTTN SSEVVLEQSP
1060 1070 1080 1090 1100
EISGNYLQIL YLLFFWVFKN LSHQTLSDLI RKTNQSLLKT ILTVTKDGLN
1110 1120 1130 1140 1150
VIGSLKNNKT FLMNEFADMF RKSRDELCEG KDLGTIPYVY SLTSSCDLLL
1160 1170 1180 1190 1200
GNEMIIDNVN LVALEIVDTI FKMYFTRDDL PVVSILFYVL GKSLFNTCMT
1210 1220 1230 1240 1250
NTYYPLFLSY IRFIIREKTE FLFQSNSRLA FDIVNGLICL CTKKIAPLRQ
1260 1270 1280 1290 1300
EAIATLYLFT KKDYERNDKS TRITQIHIIS SLFDLHLHSN ESISSVNNEA
1310 1320 1330 1340 1350
SDGFIHKAIE LLGKWAKEDF ASKKRLSVDQ TQVIESNKMI DSQLDTWIKF
1360 1370 1380 1390 1400
SDEEKLRLVN SIQKEIQSVG KRRCVLRGLE YLKEIWTENS KVLNQINKLC
1410 1420 1430 1440 1450
TEVIPLVEQE DQGFILERKA SDLASEWMVS MRDATALLTK EDVDIESLNN
1460 1470 1480 1490 1500
MQVSLQKQTT TLIDLIKQIE KLGSKFDLSQ RNLMIAMQMV IDLNKIRLKG
1510 1520 1530 1540 1550
LQAETSTKNS THEQAMNFIE KQEKNRLEIA GEYKKIKNDA ETKGTLLEVA
1560 1570 1580 1590 1600
EYTLQQYRLM QDNIDRRHRQ MKEEDLQCNG MPGWETVFVQ WETILPKAVS
1610 1620 1630 1640 1650
LLNELIEIQT ILDGLNKNEI IHKEDIYAEF AASEQLIKIC AWCIEVNETI
1660 1670 1680 1690 1700
HFPVECVSEL PQRILVANEL MKQFTSIEKM IQFVKTEYGD AENKQQKKYM
1710 1720 1730 1740 1750
FDELFKQYVE KDNWKSSLAR KIQEMQDIYQ KETDREQRET EYKKLLQRVI
1760 1770 1780 1790 1800
QLIQMGDDYQ EDVSKACERI IELEKIDSNV VDVISDDDFK ILQKLKETKK
1810 1820 1830 1840 1850
GYSSLLKGFG KKTPMEKKEE SSSDQFISEL KILEGQTNSI LCELQKLNEL
1860 1870 1880 1890 1900
EEKNYGNDVV MEKYLSIADN SMESPYFHLK WYNTIYMKQK ELENYMEAGV
1910 1920 1930 1940 1950
AAVHEIYFIY KAIIEPSGII LKESYLREIT EDFLHYKTSS VGLSSTVLDD
1960 1970 1980 1990 2000
NTNSFVSAVD DAIEMFEKAD HRKFAIALCN FIIPYFANNH EYNALAEKHK
2010 2020 2030 2040 2050
MIHKMYYEMR TTISLPFYFY SVRFLGKIFK SRDNDTNEIF NIVDSQKALS
2060 2070 2080 2090 2100
AIKPKTVNDN DSVSSTDSRE IILDCENEYI YMSKQKLVEF KQYLETLHKT
2110 2120 2130 2140 2150
SGAIVMSEAE AEKEQIDPNG DKPVIILNNV KCFVDGRVSN DFVKCNTFVN
2160 2170 2180 2190 2200
EIAKGKGAEV VKTRRIITTY RYFPSVMERE AVIKKTEITL SPVETGIADV
2210 2220 2230 2240 2250
DMMIQGLNND ICKLKSDKNA SVSGLQRLLM GILSANVNGG IGLYLTYFLS
2260 2270 2280 2290 2300
KENIHKYKEN ELAELFLIIE RIMALSKEGL MIHKNKMKVE NAQIQNVMEE
2310 2320
GYLQLEKLTK EVRKTLTEAG IL
Length:2,322
Mass (Da):270,422
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A0ACF001B5D10A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS571207 Genomic DNA Translation: EAL50587.1
BDEQ01000001 Genomic DNA Translation: GAT95018.1

NCBI Reference Sequences

More...
RefSeqi
XP_655972.1, XM_650880.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
GAT95018; GAT95018; CL6EHI_170180
rna_EHI_170180-1; rna_EHI_170180-1; EHI_170180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3410321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ehi:EHI_170180

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571207 Genomic DNA Translation: EAL50587.1
BDEQ01000001 Genomic DNA Translation: GAT95018.1
RefSeqiXP_655972.1, XM_650880.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiGAT95018; GAT95018; CL6EHI_170180
rna_EHI_170180-1; rna_EHI_170180-1; EHI_170180
GeneIDi3410321
KEGGiehi:EHI_170180

Organism-specific databases

EuPathDBiAmoebaDB:EHI_170180

Phylogenomic databases

InParanoidiC4M1E0
OMAiNINDSHH
OrthoDBi19224at2759

Family and domain databases

InterProiView protein in InterPro
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC4M1E0_ENTHI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4M1E0
Secondary accession number(s): A0A175JNH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 5, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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