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Entry version 36 (02 Jun 2021)
Sequence version 1 (07 Jul 2009)
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Protein

PPi-type phosphoenolpyruvate carboxykinase 3

Gene

PEPCK3

Organism
Entamoeba histolytica
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inorganic pyrophosphate (PPi)-dependent phosphoenolpyruvate carboxykinase, which regulates the carbon flow of the central metabolism by fixing CO2 to phosphoenolpyruvate to produce oxaloacetate. Can also produce pyruvate and diphosphate from phosphoenolpyruvate and phosphate.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Lyase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.38, 2080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PPi-type phosphoenolpyruvate carboxykinase 31 Publication (EC:4.1.1.38By similarity)
Short name:
EhPEPCK31 Publication
Short name:
PPi-PEPCK31 Publication
Alternative name(s):
Diphosphate-dependent phosphoenolpyruvate carboxykinase 3Curated
PEP carboxyphosphotransferase 3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEPCK3Curated
ORF Names:EHI_198620Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolytica
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaArchamoebaeMastigamoebidaEntamoebidaeEntamoeba
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001926 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
AmoebaDB:EHI5A_126350
AmoebaDB:EHI5A_194890
AmoebaDB:EHI5A_252600
AmoebaDB:EHI_198620
AmoebaDB:KM1_081510
AmoebaDB:KM1_309960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004347321 – 1153PPi-type phosphoenolpyruvate carboxykinase 3Add BLAST1153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and trimer; forms heterotrimers with PEPCK1 and PEPCK2.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5759.rna_EHI_198620-1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
C4LWQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1085 – 1131Sequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW6Z, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_275663_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
C4LWQ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLGESCD

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4LWQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNQEQGTDY PVLNKKKLES LANLKLAMGG HEYPTDDLTQ QGLKLAGPLL
60 70 80 90 100
EEVEESEVNH TTAPIDARLQ TFLNSYFAEC GEEVPKIPDD TFILDREGLG
110 120 130 140 150
RVLSFPPHKQ EFFCETMKSY KIKQGVLHNP AKDKRTTVGV FHICQSDVPV
160 170 180 190 200
PADKIECPKI AFLRMLKAAF YGAPDDHLII PYTAECKEPT RSWVSLYMRP
210 220 230 240 250
VVVPGVKGVK GFEHEKATEM HFFVPGNMVS CLDFVESVFG NAGNPRLSKN
260 270 280 290 300
DAALDPLGWT GHSGMAILAP HLTRMTKKEC GLPHISQATE RQKRERMCWE
310 320 330 340 350
KEDELYNDGK TFKMYCRDAS GVICTIIADN YFGYCKKEVK TQISYSANLY
360 370 380 390 400
GFAEEEHAGG AIARPSYDLG ESCDASKYAE GYKFSEMVEK NKHSIIVKEE
410 420 430 440 450
GYAVDKKYPE GIIYVPEDSV FTIEDASIKF NHNGKEESIL LTPKVNYVLP
460 470 480 490 500
NGYTIILHDT MTSRRWTLRG ILPQYTLCHK PCTVSGGGKS EISKSIRDAV
510 520 530 540 550
IEGSVFVNNK EEDFKAVQKV FDHDFSKRYA NGEVKPIHIL DPNVTLGTVV
560 570 580 590 600
ELLTPSHLFT KEHNDYISSI SPLIVELVMT IKSLYREDWK GDWQSRITVD
610 620 630 640 650
KINGNEGNEL KYRGANLSSQ YLRVGFERDE TTWRVFQLRK DFFPAAKLQM
660 670 680 690 700
EDDITASVIV PTKLLKTPIN NMQKKACKIV KNCELRLFQR PDDAVFRGFD
710 720 730 740 750
KQTEYDFSIP GHFISNYQPM TREEAKDFTK DVVRLYQYTE PMRKCLQDFV
760 770 780 790 800
AGKDEAKYIV SSSYTRLVPE GDKLVGSKNP RYLQRRPDML DPEYTYMTFK
810 820 830 840 850
AIQLYRKISD EEPLYTPVDA VLSGRRNNPP QVAKNGMKLR PLSVFAPLHY
860 870 880 890 900
FELPELLMEC ITSMTGASPS MFGAGSEGAL TKGPFNSLPA VVDLNNYLLG
910 920 930 940 950
MICCGYSGFV SSASYCGPHY KVAHDISLLI PEIWSKMIRY EQEPKYLIEH
960 970 980 990 1000
GYLEPCPDVT YNGKTYSGKR LGYRITTAFA NHFLRTLFSM PNSVMPEDFL
1010 1020 1030 1040 1050
KPELQDLAIY ADSYEYMSQT DKGIAMNYVK DGTVEGACPP LKALIYIMAN
1060 1070 1080 1090 1100
GEYNGMTRES KEFREMFDPE VVLNSEWYKE RLVTRQKLEV AKLNKDLAYL
1110 1120 1130 1140 1150
NKTIAEKPRL AETLNKQIAA VKEELQYVSS EEYLHDINGS IGTDPYPYKC

MKH
Length:1,153
Mass (Da):131,013
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E26437A084557B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS571165 Genomic DNA Translation: EAL49814.2

NCBI Reference Sequences

More...
RefSeqi
XP_655201.2, XM_650109.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
rna_EHI_198620-1; rna_EHI_198620-1; EHI_198620

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3409516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ehi:EHI_198620

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571165 Genomic DNA Translation: EAL49814.2
RefSeqiXP_655201.2, XM_650109.2

3D structure databases

SMRiC4LWQ8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_198620-1

Genome annotation databases

EnsemblProtistsirna_EHI_198620-1; rna_EHI_198620-1; EHI_198620
GeneIDi3409516
KEGGiehi:EHI_198620

Organism-specific databases

VEuPathDBiAmoebaDB:EHI5A_126350
AmoebaDB:EHI5A_194890
AmoebaDB:EHI5A_252600
AmoebaDB:EHI_198620
AmoebaDB:KM1_081510
AmoebaDB:KM1_309960

Phylogenomic databases

eggNOGiENOG502QW6Z, Eukaryota
HOGENOMiCLU_275663_0_0_1
InParanoidiC4LWQ8
OMAiDLGESCD

Enzyme and pathway databases

BRENDAi4.1.1.38, 2080

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPECK3_ENTHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4LWQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: July 7, 2009
Last modified: June 2, 2021
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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